A central tenet of Systems Neuroscience lies in an understanding of memory and behavior through learning rules, but synaptic plasticity has rarely been shown to create functional single-neuron code in...

Luo et al. identify distinct supramammillary-dentate gyrus subcircuits that differentially regulate memory and emotion. In Alzheimer’s disease (AD) models, these pathways show aberrant activity, but targeted optogenetic activation selectively restores cognitive or affective functions, revealing circuit-level mechanisms underlying diverse AD symptoms and highlighting potential therapeutic targets.

To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single-neuron and single-spike re…

Nature Neuroscience - The face reveals more than just emotion. Cazettes, Reato and colleagues show that subtle facial movements reveal hidden cognitive states, reflecting the brain’s ongoing...

The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment [1][1] and generates offline “replay” [2][2],[3][3] for the purposes of recall [4][4], planni...

Here, the authors created a virtual reality task for monkeys and mice to explore if internal states like attention are similar across species. Their facial expressions during the task were similar, su...

A systems-level understanding of cortical computation requires insight into how neural codes are transformed across distinct brain circuits. In the mammalian cortex, one of the few systems where such ...

Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

The cognitive neuroscience community using M/EEG has not converged on measures of task-related inter-regional brain connectivity that generalize acros…