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Reposted by David Katz

Carl Zimmer @carlzimmer.com · 2d

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

nyti.ms

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David Katz @katzlab.bsky.social · 1d

Awesome science!

Eric Topol @erictopol.bsky.social · 1d

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

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David Katz @katzlab.bsky.social · 1d

Really enjoyed my visit

Maureen Barr @barrlab.bsky.social · 2d

Thanks @katzlab.bsky.social for a 🤯 seminar!

The function of histone modifying enzymes in transgenerational phenotypes, neurodevelopmental disorders and Alzheimer’s disease

Using C. elegans & mouse models

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David Katz @katzlab.bsky.social · 1d

LOL

David Katz @katzlab.bsky.social · 1d

Happy to be back @princeton.edu , where I received fabulous PhD training, to give a talk in MolBio and serve as a Health Science panelist for the Many Minds Many Stripes 125th Graduate Anniversary celebration!

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David Katz @katzlab.bsky.social · 3d

Really looking forward to visiting Rutgers and @barrlab.bsky.social tomorrow!

Maureen Barr @barrlab.bsky.social · 3d

Rutgers peeps: David Katz is presenting this exciting work tomorrow Oct 8 at 2pm in Waksman 1001. #celegans

David Katz @katzlab.bsky.social · 3d

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

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David Katz @katzlab.bsky.social · 3d

If the same thing is true in the corresponding human patients, might it be possible to revert cognitive/behavior deficits in the human patients also?

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David Katz @katzlab.bsky.social · 3d

So, expressing germline genes in neurons can block their function in a way that is reversible if you shut off the inappropriate transcription

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David Katz @katzlab.bsky.social · 3d

Turning off the ectopic germline gene expression in the neurons of worms that already have a chemotaxis behavior defect, reverses the behavior back to normal

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David Katz @katzlab.bsky.social · 3d

So, could the chemotaxis behavior defect be due to an ongoing defect in an intact nervous system? If so, might it be possible to reverse the chemotaxis behavior defect even after the nervous system has fully formed?

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David Katz @katzlab.bsky.social · 3d

And an intact nervous system

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David Katz @katzlab.bsky.social · 3d

No changes in the embryonic lineage

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David Katz @katzlab.bsky.social · 3d

Progeny of spr-5 (lsd1) and met-2 (setdb1) double mutants have germline genes expressed in somatic cells, which causes a severe chemotaxis behavior defect, but surprise...

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David Katz @katzlab.bsky.social · 3d

The invariant C. elegans lineage and adult nervous system provide the perfect opportunity to find out how every cell responds to inappropriately inherited chromatin and altered transcription

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David Katz @katzlab.bsky.social · 3d

Ever wonder how something as broad as a chromatin mutant causes cell specific phenotypes?

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David Katz @katzlab.bsky.social · 3d

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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David Katz @katzlab.bsky.social · 8d

So proud of my graduate student Monica Reeves for winning program student of the year in the Genetics and Molecular Biology program at Emory University @emory-gmb.bsky.social

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David Katz @katzlab.bsky.social · 29d

Really cool. Looking forward to reading it. The Peters’ lab publishes amazing science.

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David Katz @katzlab.bsky.social · Sep 9

A lot of important views expressed here. I am just curious how the potential to flood the zone with fake papers feeds into all of this?

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Reposted by David Katz

Oded Rechavi @odedrechavi.bsky.social · Aug 16

C. elegans initiating a small RNA response

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David Katz @katzlab.bsky.social · Aug 11

Very excited to be back at the Epigenetics GRC, this time in Barcelona! #epigeneticsgrc2025

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David Katz @katzlab.bsky.social · Aug 4

Stand up for science. Stand up as if our lives and our economy depend on it. Because, actually, they do. #standupforscience

Colette Delawalla @cdelawalla.bsky.social · Aug 4

Congress says they have our back...let's hold them to their word!

All gas, no breaks this August with the 31 Days of Action campaign.

Sign up for our daily action notes here: act.standupforscience.net/forms/31-day...

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David Katz @katzlab.bsky.social · Aug 4

Quiet. Don’t tell anyone.

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David Katz @katzlab.bsky.social · Jul 31

Thank you. I will put my head down and continue to do the best science that I can.

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David Katz @katzlab.bsky.social · Jul 31

Harmit please tell us that it is all going to be alright.

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