Konrad Hinsen
@khinsen.net
Researcher at CNRS (France). Computational science, in particular computational biophysics. Metascience, in particular the evolution of science in the digital era.
More active in the Fediverse: https://scholar.social/@khinsen
More active in the Fediverse: https://scholar.social/@khinsen
Reposted by Konrad Hinsen
November 26, 2025 at 6:35 PM
Reposted by Konrad Hinsen
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by Konrad Hinsen
Call for contributions/demos for programming 2026 in Munich, March. Ooh I'll have some serious shit cooking by then.
2026.programming-conference.org/home/substra...
2026.programming-conference.org/home/substra...
Substrates 2026 - Substrates-26 - ‹Programming› 2026
An increasing number of researchers see their work as interactive authoring tools or software substrates for interactive computational media. By talking about “authoring tools”, we remove the divide b...
2026.programming-conference.org
November 18, 2025 at 10:15 PM
Call for contributions/demos for programming 2026 in Munich, March. Ooh I'll have some serious shit cooking by then.
2026.programming-conference.org/home/substra...
2026.programming-conference.org/home/substra...
Reposted by Konrad Hinsen
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 11:37 AM
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
New blog post: "Explorable explorable explanations"
Building on Bret Victor's concept of "explorable explanations" for scientific publishing.
blog.khinsen.net/posts/2025/1...
🧪 #MetaSci
Building on Bret Victor's concept of "explorable explanations" for scientific publishing.
blog.khinsen.net/posts/2025/1...
🧪 #MetaSci
Konrad Hinsen's blog
blog.khinsen.net
November 12, 2025 at 8:55 AM
New blog post: "Explorable explorable explanations"
Building on Bret Victor's concept of "explorable explanations" for scientific publishing.
blog.khinsen.net/posts/2025/1...
🧪 #MetaSci
Building on Bret Victor's concept of "explorable explanations" for scientific publishing.
blog.khinsen.net/posts/2025/1...
🧪 #MetaSci
Reposted by Konrad Hinsen
AI hype letter remains open for more signatures tinyurl.com/Sign-Letter-...
CryptPad
tinyurl.com
November 10, 2025 at 9:48 AM
AI hype letter remains open for more signatures tinyurl.com/Sign-Letter-...
Reposted by Konrad Hinsen
Scientists and scholars in AI and its social impacts call on von der Leyen to retract #AIHype statement.
@olivia.science
@abeba.bsky.social
@irisvanrooij.bsky.social
@alexhanna.bsky.social
@rocher.lc
@danmcquillan.bsky.social
@robin.berjon.com
& many others have signed
www.iccl.ie/press-releas...
@olivia.science
@abeba.bsky.social
@irisvanrooij.bsky.social
@alexhanna.bsky.social
@rocher.lc
@danmcquillan.bsky.social
@robin.berjon.com
& many others have signed
www.iccl.ie/press-releas...
Scientists call on the President of the European Commission to retract AI hype statement
Experts in AI call on the President of the European Commission to retract unscientific AI hype statement she made in the budget speech.
www.iccl.ie
November 10, 2025 at 9:48 AM
Scientists and scholars in AI and its social impacts call on von der Leyen to retract #AIHype statement.
@olivia.science
@abeba.bsky.social
@irisvanrooij.bsky.social
@alexhanna.bsky.social
@rocher.lc
@danmcquillan.bsky.social
@robin.berjon.com
& many others have signed
www.iccl.ie/press-releas...
@olivia.science
@abeba.bsky.social
@irisvanrooij.bsky.social
@alexhanna.bsky.social
@rocher.lc
@danmcquillan.bsky.social
@robin.berjon.com
& many others have signed
www.iccl.ie/press-releas...
Reposted by Konrad Hinsen
Played with @khinsen.net's hypedoc today. Wow, really good. @tomasp.net u would like. ALT + CLICK on most elements to reveal the source code, all the source code elements are hyperlinked. So deep for exploration.
hyperdoc.khinsen.net/94FE4-microg...
hyperdoc.khinsen.net/94FE4-microg...
November 8, 2025 at 9:54 PM
Played with @khinsen.net's hypedoc today. Wow, really good. @tomasp.net u would like. ALT + CLICK on most elements to reveal the source code, all the source code elements are hyperlinked. So deep for exploration.
hyperdoc.khinsen.net/94FE4-microg...
hyperdoc.khinsen.net/94FE4-microg...
Reposted by Konrad Hinsen
Had a fun meeting with @ronentk.me and we set a simple landing page for @atproto.science 🧪
Take a look at atproto.science
Take a look at atproto.science
ATProto Science
atproto.science
October 23, 2025 at 2:41 PM
Had a fun meeting with @ronentk.me and we set a simple landing page for @atproto.science 🧪
Take a look at atproto.science
Take a look at atproto.science
Reposted by Konrad Hinsen
Finally transferring my mastodon book thread on Hasok Chang's Is Water H2O? Evidence, Realism and Pluralism over here. My notes are somewhat haphazard, just remarking on things I found interesting at first read. And the thread appears to end abruptly. Been a while; can't remember why.
October 17, 2025 at 5:36 PM
Finally transferring my mastodon book thread on Hasok Chang's Is Water H2O? Evidence, Realism and Pluralism over here. My notes are somewhat haphazard, just remarking on things I found interesting at first read. And the thread appears to end abruptly. Been a while; can't remember why.
Reposted by Konrad Hinsen
Totally agree – we need peer review for research software. At least the “artisanal” stuff – those small, medium-size scripts, notebooks, workflows that drive much science. Reviewing them would make results clearer, more reliable, and way more trustworthy.
#science #openscience #opensource
#science #openscience #opensource
New publication: "Reviewing research software"
Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all?
doi.org/10.1109/MCSE...
Preprint: hal.science/hal-05274018
🧪 #openscience #metascience
Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all?
doi.org/10.1109/MCSE...
Preprint: hal.science/hal-05274018
🧪 #openscience #metascience
Reviewing Research Software
Every research project in computational science requires writing some code, even if it’s only a few scripts. This code is instrumental in generating results, and often important for understanding in d...
doi.org
October 14, 2025 at 6:57 AM
Totally agree – we need peer review for research software. At least the “artisanal” stuff – those small, medium-size scripts, notebooks, workflows that drive much science. Reviewing them would make results clearer, more reliable, and way more trustworthy.
#science #openscience #opensource
#science #openscience #opensource
Reposted by Konrad Hinsen
This is not an exaggeration.
Everything — *everything* — is downstream of energy. Our technological prowess is downstream of the massive power subsidies we have been getting from fossil fuels.
Everything — *everything* — is downstream of energy. Our technological prowess is downstream of the massive power subsidies we have been getting from fossil fuels.
You're living through one of the biggest technological transformations in world history and it has nothing to do with AI
Grid scale batteries are changing our electricity system. Excellent new visual story on batteries in FT today shows just how far this technology has evolved.
Fasten your seatbelts, this is just the beginning.
ig.ft.com/mega-batteri...
Fasten your seatbelts, this is just the beginning.
ig.ft.com/mega-batteri...
October 14, 2025 at 2:52 PM
This is not an exaggeration.
Everything — *everything* — is downstream of energy. Our technological prowess is downstream of the massive power subsidies we have been getting from fossil fuels.
Everything — *everything* — is downstream of energy. Our technological prowess is downstream of the massive power subsidies we have been getting from fossil fuels.
Reposted by Konrad Hinsen
«The input does not cause the output in an authorial sense, much like input to a library search engine does not cause relevant articles and books to be written (Guest, 2025). The respective authors wrote those, not the search query!» via @olivia.science via#2 @irisvanrooij.bsky.social - thank you
important on LLMs for academics:
1️⃣ LLMs are usefully seen as lossy content-addressable systems
2️⃣ we can't automatically detect plagiarism
3️⃣ LLMs automate plagiarism & paper mills
4️⃣ we must protect literature from pollution
5️⃣ LLM use is a CoI
6️⃣ prompts do not cause output in authorial sense
1️⃣ LLMs are usefully seen as lossy content-addressable systems
2️⃣ we can't automatically detect plagiarism
3️⃣ LLMs automate plagiarism & paper mills
4️⃣ we must protect literature from pollution
5️⃣ LLM use is a CoI
6️⃣ prompts do not cause output in authorial sense
October 14, 2025 at 5:01 AM
«The input does not cause the output in an authorial sense, much like input to a library search engine does not cause relevant articles and books to be written (Guest, 2025). The respective authors wrote those, not the search query!» via @olivia.science via#2 @irisvanrooij.bsky.social - thank you
New publication: "Reviewing research software"
Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all?
doi.org/10.1109/MCSE...
Preprint: hal.science/hal-05274018
🧪 #openscience #metascience
Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all?
doi.org/10.1109/MCSE...
Preprint: hal.science/hal-05274018
🧪 #openscience #metascience
Reviewing Research Software
Every research project in computational science requires writing some code, even if it’s only a few scripts. This code is instrumental in generating results, and often important for understanding in d...
doi.org
October 9, 2025 at 7:34 AM
New publication: "Reviewing research software"
Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all?
doi.org/10.1109/MCSE...
Preprint: hal.science/hal-05274018
🧪 #openscience #metascience
Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all?
doi.org/10.1109/MCSE...
Preprint: hal.science/hal-05274018
🧪 #openscience #metascience
Reposted by Konrad Hinsen
We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.
October 1, 2025 at 2:38 PM
We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.
Reposted by Konrad Hinsen
I'm at #uist2025 presenting our new work with @jonathoda.bsky.social!
𝗗𝗲𝗻𝗶𝗰𝗲𝗸 is a computational substrate for end-user programming that makes it easy to implement programming experiences like programming by demonstration, collaborative editing and more!
tomasp.net/academic/pap...
𝗗𝗲𝗻𝗶𝗰𝗲𝗸 is a computational substrate for end-user programming that makes it easy to implement programming experiences like programming by demonstration, collaborative editing and more!
tomasp.net/academic/pap...
September 30, 2025 at 6:13 AM
I'm at #uist2025 presenting our new work with @jonathoda.bsky.social!
𝗗𝗲𝗻𝗶𝗰𝗲𝗸 is a computational substrate for end-user programming that makes it easy to implement programming experiences like programming by demonstration, collaborative editing and more!
tomasp.net/academic/pap...
𝗗𝗲𝗻𝗶𝗰𝗲𝗸 is a computational substrate for end-user programming that makes it easy to implement programming experiences like programming by demonstration, collaborative editing and more!
tomasp.net/academic/pap...
Question to Linux experts: Where does this weird pop-up come from that I get whenever pressing a deadkey on my keyboard? How can I disable it?
I see this since I updated from Debian 12 to Debian 13. I see it only in a few programs, such as xterm and Emacs, where it often covers text I need to see.
I see this since I updated from Debian 12 to Debian 13. I see it only in a few programs, such as xterm and Emacs, where it often covers text I need to see.
September 24, 2025 at 12:03 PM
Question to Linux experts: Where does this weird pop-up come from that I get whenever pressing a deadkey on my keyboard? How can I disable it?
I see this since I updated from Debian 12 to Debian 13. I see it only in a few programs, such as xterm and Emacs, where it often covers text I need to see.
I see this since I updated from Debian 12 to Debian 13. I see it only in a few programs, such as xterm and Emacs, where it often covers text I need to see.
Reposted by Konrad Hinsen
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...
www.chemistryworld.com/opinion/the-...
The simple machine that visualised atomic orbitals
In 1931, Harvey Elliott White developed a device that traced out the shapes of electron clouds by approximating solutions to the Schrödinger equation
www.chemistryworld.com
September 18, 2025 at 9:37 AM
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...
www.chemistryworld.com/opinion/the-...
Reposted by Konrad Hinsen
One thing that fascists understand well is that social and traditional media are both media and need to be controlled to undermine democracy.
Meanwhile, in camp democracy no government seems to fathom this simple fact let alone act in consequence.
We need more strategy less meekness.
Meanwhile, in camp democracy no government seems to fathom this simple fact let alone act in consequence.
We need more strategy less meekness.
Andreessen Horowitz, which will be one of three firms to lead the acquisition of TikTok, is headed by Marc Andreessen, a Silicon Valley tech titan who considered himself to be "an unpaid intern" of Elon Musk's DOGE. But he's not the only major Trump ally involved with this deal
TikTok’s U.S. business would be controlled by an investor consortium including Oracle, Silver Lake and Andreessen Horowitz under a framework the U.S. and China are finalizing.
September 17, 2025 at 6:33 AM
One thing that fascists understand well is that social and traditional media are both media and need to be controlled to undermine democracy.
Meanwhile, in camp democracy no government seems to fathom this simple fact let alone act in consequence.
We need more strategy less meekness.
Meanwhile, in camp democracy no government seems to fathom this simple fact let alone act in consequence.
We need more strategy less meekness.
Reposted by Konrad Hinsen
"Epistemic oligarchies: capture and concentration through science reform", a new preprint by Sven Ulpts (not here), Sheena Bartscherer (also not here), @nicolecnelson.bsky.social and me. Read it here: zenodo.org/records/1713... 1/
Epistemic oligarchies: capture and concentration through science reform
In this paper we describe how current efforts to reform science create oligarchic power structures within science and prepare scientific products for the uptake by existing oligarchic actors like Big ...
zenodo.org
September 17, 2025 at 8:23 AM
"Epistemic oligarchies: capture and concentration through science reform", a new preprint by Sven Ulpts (not here), Sheena Bartscherer (also not here), @nicolecnelson.bsky.social and me. Read it here: zenodo.org/records/1713... 1/
Reposted by Konrad Hinsen
LINK ROT: 38% webpages that existed in 2013 were no longer available 10 years later.
Even among pages that existed in 2021, 22% no longer accessible just two years later. This is often because individual page was deleted or removed on otherwise functional website.
Many implications for knowledge 🧪
Even among pages that existed in 2021, 22% no longer accessible just two years later. This is often because individual page was deleted or removed on otherwise functional website.
Many implications for knowledge 🧪
September 14, 2025 at 11:19 PM
LINK ROT: 38% webpages that existed in 2013 were no longer available 10 years later.
Even among pages that existed in 2021, 22% no longer accessible just two years later. This is often because individual page was deleted or removed on otherwise functional website.
Many implications for knowledge 🧪
Even among pages that existed in 2021, 22% no longer accessible just two years later. This is often because individual page was deleted or removed on otherwise functional website.
Many implications for knowledge 🧪
Reposted by Konrad Hinsen
Slides from my talk "Critical Architecture/Software Theory" at PPIG 2025 in Belgrade: tpetricek.github.io/Talks/2025/c...
The talk has been a great excuse to organize some more ideas, on top of my earlier article on the topic: tomasp.net/architecture/
The talk has been a great excuse to organize some more ideas, on top of my earlier article on the topic: tomasp.net/architecture/
September 9, 2025 at 1:06 PM
Slides from my talk "Critical Architecture/Software Theory" at PPIG 2025 in Belgrade: tpetricek.github.io/Talks/2025/c...
The talk has been a great excuse to organize some more ideas, on top of my earlier article on the topic: tomasp.net/architecture/
The talk has been a great excuse to organize some more ideas, on top of my earlier article on the topic: tomasp.net/architecture/
Reposted by Konrad Hinsen
I'm still a bit shocked at the attention because I expected something, but this is immense. 11k views on zenodo!? What? Thank you all! (doi.org/10.5281/zeno...)
Wondering if my new followers are into my research? Shall I do a thread of my work for you all? Do you like papers also like below? 🥰
Wondering if my new followers are into my research? Shall I do a thread of my work for you all? Do you like papers also like below? 🥰
Oh, gosh! It's out! Delighted with the process at Computational Brain & Behavior; thankful to all especially @irisvanrooij.bsky.social for inviting me to the workshop and Todd Wareham for editing it! Hope you enjoy:
What Makes a Good Theory, and How Do We Make a Theory Good? doi.org/10.1007/s421...
What Makes a Good Theory, and How Do We Make a Theory Good? doi.org/10.1007/s421...
September 7, 2025 at 7:50 AM
I'm still a bit shocked at the attention because I expected something, but this is immense. 11k views on zenodo!? What? Thank you all! (doi.org/10.5281/zeno...)
Wondering if my new followers are into my research? Shall I do a thread of my work for you all? Do you like papers also like below? 🥰
Wondering if my new followers are into my research? Shall I do a thread of my work for you all? Do you like papers also like below? 🥰
Reposted by Konrad Hinsen
Very cool postdoc opportunity (at intersection of physics, philosophy, and complex systems) ⬇️
Postdoc job! I expect to have an opening at Johns Hopkins for a postdoctoral researcher working somewhere in the broad realms of physics, philosophy, and complexity. Apply at Academic Jobs Online:
academicjobsonline.org/ajo/jobs/30496
academicjobsonline.org/ajo/jobs/30496
Johns Hopkins University, Physics and Astronomy
Job #AJO30496, Postdoctoral Fellow in Foundations of Physics, Complexity, and Emergence, Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland, US
academicjobsonline.org
September 5, 2025 at 6:02 PM
Very cool postdoc opportunity (at intersection of physics, philosophy, and complex systems) ⬇️
Reposted by Konrad Hinsen
Good scenario planning doesn’t predict. It…
- Models systemic forces
- Explores how they may collide to generate a wide range possibilities
- Prepares multiple contingency plans
Adaptation beats prediction in VUCA environments.
- Models systemic forces
- Explores how they may collide to generate a wide range possibilities
- Prepares multiple contingency plans
Adaptation beats prediction in VUCA environments.
Predictions feel safe. But 8m into 2025, some of The Economist’s most confident forecasts are already wobbling.
Why? Because the world is not linear. It’s a tangled web of feedback loops, emergent patterns & path dependencies.
#Complexity isn’t optional.
manlius.substack.com/p/the-past-t...
Why? Because the world is not linear. It’s a tangled web of feedback loops, emergent patterns & path dependencies.
#Complexity isn’t optional.
manlius.substack.com/p/the-past-t...
The paths and loops we miss: complexity lessons from The World Ahead 2025
AI, trade wars and energy shifts aren’t separate stories
manlius.substack.com
September 6, 2025 at 7:27 AM
Good scenario planning doesn’t predict. It…
- Models systemic forces
- Explores how they may collide to generate a wide range possibilities
- Prepares multiple contingency plans
Adaptation beats prediction in VUCA environments.
- Models systemic forces
- Explores how they may collide to generate a wide range possibilities
- Prepares multiple contingency plans
Adaptation beats prediction in VUCA environments.