Kilian Schober
@kischober.bsky.social
MD Microbiology & Virology. Understanding & Engineering Human T Cell Immunity in Erlangen, Germany (www.schoberlab.de). Cycling. BVB. Cinema. Family.
Pinned
Kilian Schober
@kischober.bsky.social
· Oct 8
TCR activation impairs CAR-T cytotoxicity against separate target cells
Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR ...
www.biorxiv.org
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Reposted by Kilian Schober
Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells @nature.com #Germain @niaidnews.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 26, 2025 at 5:36 PM
Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells @nature.com #Germain @niaidnews.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kilian Schober
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
November 26, 2025 at 3:47 PM
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Reposted by Kilian Schober
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results @nature.com
www.nature.com/articles/d41...
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results @nature.com
www.nature.com/articles/d41...
November 26, 2025 at 3:12 PM
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results @nature.com
www.nature.com/articles/d41...
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results @nature.com
www.nature.com/articles/d41...
Reposted by Kilian Schober
Agentic AI systems are becoming available for use in science – but can we trust them?
November 26, 2025 at 12:55 PM
Agentic AI systems are becoming available for use in science – but can we trust them?
Reposted by Kilian Schober
Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods
TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.
www.nature.com
November 25, 2025 at 10:38 PM
Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)
Reposted by Kilian Schober
We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.
November 25, 2025 at 1:06 AM
We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.
Reposted by Kilian Schober
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods
TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.
www.nature.com
November 24, 2025 at 9:38 PM
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...
Reposted by Kilian Schober
Excited to announce that I’ve recently transitioned into an Assistant Professor role in the Division of Translational Science and Therapeutics @Fred Hutch.
October 10, 2025 at 6:18 PM
Excited to announce that I’ve recently transitioned into an Assistant Professor role in the Division of Translational Science and Therapeutics @Fred Hutch.
Reposted by Kilian Schober
"We thank the reviewers for their helpful suggestions"
November 23, 2025 at 11:19 AM
"We thank the reviewers for their helpful suggestions"
Reposted by Kilian Schober
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias https://www.biorxiv.org/content/10.1101/2025.11.19.688845v1
November 21, 2025 at 11:16 PM
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias https://www.biorxiv.org/content/10.1101/2025.11.19.688845v1
🚀 New bioRxiv preprint!
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Understanding antigen reactivity is crucial for characterizing CD4+ T helper (Th) cell fate, yet conventional peptide restimulation assays introduce phenotypic bias by activating cells ex vivo. Howeve...
www.biorxiv.org
November 22, 2025 at 8:39 AM
🚀 New bioRxiv preprint!
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states.
🔗 www.biorxiv.org/content/10.1...
(1/5)
Reposted by Kilian Schober
Großer Erfolg: Die @dfg.de fördert einen neuen Sonderforschungsbereich an der FAU, der Autoimmunerkrankungen untersucht. Zudem wurde für gleich zwei Transregio-Projekte mit FAU-Beteiligung eine weitere Förderperiode bewilligt. 🥳
👇 Mehr erfahren: www.fau.de/2025/11/news...
👇 Mehr erfahren: www.fau.de/2025/11/news...
FAU mit drei Sonderforschungsbereichen erfolgreich
Die DFG fördert an der FAU einen neuen Sonderforschungsbereich. Für zwei Transregio-Projekte mit FAU-Beteiligung hat die DFG eine weitere Förderperiode bewilligt.
www.fau.de
November 21, 2025 at 2:52 PM
Großer Erfolg: Die @dfg.de fördert einen neuen Sonderforschungsbereich an der FAU, der Autoimmunerkrankungen untersucht. Zudem wurde für gleich zwei Transregio-Projekte mit FAU-Beteiligung eine weitere Förderperiode bewilligt. 🥳
👇 Mehr erfahren: www.fau.de/2025/11/news...
👇 Mehr erfahren: www.fau.de/2025/11/news...
Reposted by Kilian Schober
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 9:00 PM
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Reposted by Kilian Schober
Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis
To study the association of Epstein–Barr virus (EBV) and multiple sclerosis (MS) as compared to 10 different control diseases, 10,669 patients with MS and 42,222 controls were identified by ICD10 cod...
onlinelibrary.wiley.com
November 13, 2025 at 3:56 PM
Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Kilian Schober
Today I appointed Jürgen Held as a Professor at FAU.
His work advances fungal diagnostics, metagenomic infection detection, and AI-based risk assessment. He brings science and clinical practice together to identify infections earlier and treat patients more precisely.
His work advances fungal diagnostics, metagenomic infection detection, and AI-based risk assessment. He brings science and clinical practice together to identify infections earlier and treat patients more precisely.
November 13, 2025 at 12:10 PM
Today I appointed Jürgen Held as a Professor at FAU.
His work advances fungal diagnostics, metagenomic infection detection, and AI-based risk assessment. He brings science and clinical practice together to identify infections earlier and treat patients more precisely.
His work advances fungal diagnostics, metagenomic infection detection, and AI-based risk assessment. He brings science and clinical practice together to identify infections earlier and treat patients more precisely.
Reposted by Kilian Schober
New Comment
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
Long COVID is an umbrella term for the heterogeneous long-term consequences of SARS-CoV-2
infection. It encompasses a wide spectrum of phenotypes (sometimes overlapping), and
its underlying mechanisms...
www.thelancet.com
November 9, 2025 at 7:52 PM
New Comment
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Reposted by Kilian Schober
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
newyorkermag.visitlink.me
November 6, 2025 at 9:00 PM
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV‐Specific CD8+ T Cells
Differentially methylated regions (DMRs) within the ZEB2 locus progressively demethylate during CD4+ and CD8+ T cell differentiation into cytotoxic CD4+ and CD8+ TEMRA subsets, respectively. This epi...
onlinelibrary.wiley.com
November 6, 2025 at 2:29 PM
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
Reposted by Kilian Schober
#PreprintClub is now on Bluesky!
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
December 10, 2024 at 1:51 PM
#PreprintClub is now on Bluesky!
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Reposted by Kilian Schober
Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests.
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:52 PM
Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests.
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
www.life-science-alliance.org/content/9/1/...
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
T helper (Th) cell lineages are linked to metabolism, but precise mechanisms in human Th1 cells remain unclear. We addressed this question by in vitro stimulation and CRISPR/Cas9-mediated gene editing...
www.life-science-alliance.org
November 4, 2025 at 9:35 AM
www.life-science-alliance.org/content/9/1/...
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
November 3, 2025 at 10:16 AM
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
Reposted by Kilian Schober
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 30, 2025 at 3:35 PM
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
Reposted by Kilian Schober
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
bulletin.ndorms.ox.ac.uk
October 29, 2025 at 8:55 PM
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Reposted by Kilian Schober
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors