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Reposted by Kilian Schober

Waggoner Lab @labwaggoner.bsky.social · 1d

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells
www.biorxiv.org/content/10.1...

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Reposted by Kilian Schober

Jörg Vogel @jorg-vogel-lab.bsky.social · 1d

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

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Reposted by Kilian Schober

Our World in Data @ourworldindata.org · 1d

Declining child mortality, fast and slow

The image depicts a line chart illustrating child mortality rates, specifically the estimated percentage of newborns who do not survive past the age of five. The chart has two distinct lines: one representing Sweden in blue and the other representing South Korea in red.

Starting in the early 1800s, the blue line for Sweden shows a gradual decline in the child mortality rate, fluctuating around 35% at the beginning and continuing to decrease steadily over the years, reaching nearly 0% by 2023.

In contrast, the red line for South Korea begins more steeply in the mid-20th century, experiencing a rapid decline after 1950, ultimately approaching a very low percentage by 2023.

The sources for the data are listed at the bottom as Gapminder (2015) and the UN Inter-agency Group for Child Mortality Estimation (2025). The entire chart is labeled as CC BY for Creative Commons licensing.

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Kilian Schober @kischober.bsky.social · 2d

This is up to us!

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Reposted by Kilian Schober

saligramalab.bsky.social @saligramalab.bsky.social · 2d

Does #bluesky still #exist or is it #dead?

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Reposted by Kilian Schober

FAU Erlangen-Nbg @fau.de · 2d

Einem Ärzteteam des Uniklinikums Erlangen ist es weltweit erstmals gelungen, eine junge Patientin mit therapieresistenter, schwerer chronisch-entzündlicher Darmerkrankung erfolgreich mit einer CAR-T-Zell-Therapie zu behandeln.

Mehr erfahren: go.fau.de/1cb-e

CAR-T-Zell-Therapie erstmals bei schwerer Darmerkrankung erfolgreich

Einem Ärzteteam am Deutschen Zentrum Immuntherapie des Uniklinikums Erlangen ist es weltweit erstmals gelungen, eine junge Patientin mit therapieresistenter…

go.fau.de

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Reposted by Kilian Schober

bioRxiv Immunology @biorxiv-immuno.bsky.social · 2d

TCR activation impairs CAR-T cytotoxicity against separate target cells https://www.biorxiv.org/content/10.1101/2025.10.07.680634v1

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Kilian Schober @kischober.bsky.social · 2d

@fau.de, @helmholtzmunich.bsky.social, @uni-magdeburg.de, @tum.de, @uni-wuerzburg.de, @badw.de, #BMFTR, @dfg.de, @ekfstiftung.bsky.social, @yellow4flavi.bsky.social.

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Kilian Schober @kischober.bsky.social · 2d

When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?

Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.

www.biorxiv.org/content/10.1...

TCR activation impairs CAR-T cytotoxicity against separate target cells

Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR ...

www.biorxiv.org

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Kilian Schober @kischober.bsky.social · 2d

I think often the prizes also go to people who were first authors or trainees at the time of the discovery (or the seminal paper) if there was one, so were not PIs at the time. There is no easy solution because if you award 10 people instead of 2-3, person #11 ans #12 will be treated „unfairly“.

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Kilian Schober @kischober.bsky.social · 3d

Congrats to you for your work and for congratulating the winners although could have been among them.

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Reposted by Kilian Schober

FAU Erlangen-Nbg @fau.de · 3d

Killerzellen des Immunsystems vermehren sich, wenn sie auf eine Infektion stoßen, um diese zu bekämpfen. Allerdings gilt das nicht für jede Killerzelle. Woran liegt es, ob es zur Vermehrung kommt oder nicht? FAU-Forschende sind dieser Frage nachgegangen.

www.fau.de/2025/10/news...

Killerzellen: Wie das Immunsystem seine Abwehrtruppen auswählt

Wenn Killerzellen des Immunsystems auf Anzeichen einer Infektion stoßen, teilen sich manche von ihnen danach rasant. Sie wachsen so zu einer großen Abwehrtruppe heran, die dann den Erreger bekämpft.

www.fau.de

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Kilian Schober @kischober.bsky.social · 3d

“I was never working alone—there were people all over the world who shared similar ideas,” he said. “I see this award as one that represents all of those people who have contributed to this research alongside me.”

Prices go to individual people, but Sakaguchi shows how to acknowledge the field.

Kai Kupferschmidt @kakape.bsky.social · 4d

“Anyone who does not have an autoimmune disease, that’s because of these regulatory T cells,” says Markus Feuerer, an immunologist at the Leibniz Institute for Immunotherapy.

www.science.org/content/arti...

Medicine Nobel for researchers who identified immune system’s security guards

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

www.science.org

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Reposted by Kilian Schober

Joe Sabatino @jsabatino37.bsky.social · 4d

A really nice overview of key Treg discoveries relevant for today's exciting Nobel announcement
www.nobelprize.org/uploads/2025...

www.nobelprize.org

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Reposted by Kilian Schober

Kilian Schober @kischober.bsky.social · 3d

Free link to paper: sites.google.com/view/schober...

Schober Lab - Publications

For a complete list, see Google scholar.

sites.google.com

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Kilian Schober @kischober.bsky.social · 3d

Free link to paper: sites.google.com/view/schober...

Schober Lab - Publications

For a complete list, see Google scholar.

sites.google.com

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Kilian Schober @kischober.bsky.social · 3d

Many thanks!!

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Kilian Schober @kischober.bsky.social · 4d

German press release: www.uk-erlangen.de/presse/press...

Wie das Immunsystem seine Abwehrtruppen auswählt

Wenn Killerzellen des Immunsystems auf Anzeichen einer Infektion stoßen, teilen sich manche von ihnen danach rasant. Sie wachsen so zu einer großen Abwehrtruppe heran, die dann den Erreger bekämpft. A...

www.uk-erlangen.de

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Kilian Schober @kischober.bsky.social · 4d

Thanks for highlighting!

Reposted by Kilian Schober

Waggoner Lab @labwaggoner.bsky.social · 6d

Clonal recruitment after vaccination is governed by a TCR avidity threshold, whereas probabilistic expansion preserves repertoire polyclonality @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

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Reposted by Kilian Schober

Michael Platten, MD @michael-platten.bsky.social · 6d

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

The immunology of brain tumors

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

www.science.org

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Reposted by Kilian Schober

Seth Thomas Scanlon @immunoeditor.bsky.social · 6d

This week in #Science #Immunology! 👇

Kilian Schober @kischober.bsky.social · 6d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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Kilian Schober @kischober.bsky.social · 6d

Thank you!

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Reposted by Kilian Schober

saligramalab.bsky.social @saligramalab.bsky.social · 6d

Beautiful paper, worth a read, lots of #TCR work -of course I am biased as I love #TCRs www.science.org/doi/10.1126/...

Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity

Clonal recruitment is governed by a T cell receptor avidity threshold, whereas probabilistic expansion preserves repertoire polyclonality.

www.science.org

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Kilian Schober @kischober.bsky.social · 6d

Merci, Ben!

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