Le Xiong
@lexiong.bsky.social
Mucosal Immunology
PhD candidate @WEHI
PhD candidate @WEHI
Reposted by Le Xiong
The November issue of #ScienceImmunology is out!
This month's cover highlights how B cells can acquire antigens from large malarial parasites and recruit different types of CD4 T cell help, which could inform future vaccine designs for malaria. https://scim.ag/4oTNJMn
This month's cover highlights how B cells can acquire antigens from large malarial parasites and recruit different types of CD4 T cell help, which could inform future vaccine designs for malaria. https://scim.ag/4oTNJMn
November 10, 2025 at 10:00 PM
The November issue of #ScienceImmunology is out!
This month's cover highlights how B cells can acquire antigens from large malarial parasites and recruit different types of CD4 T cell help, which could inform future vaccine designs for malaria. https://scim.ag/4oTNJMn
This month's cover highlights how B cells can acquire antigens from large malarial parasites and recruit different types of CD4 T cell help, which could inform future vaccine designs for malaria. https://scim.ag/4oTNJMn
Reposted by Le Xiong
Introducing Andy Gao, postdoctoral fellow at John Curtin School of Medical Research, ANU! He will present his research on T & B cell collaboration in vaccination & parasite infection at #IUIS2025, with the presentation "Can a B cell eat a parasite? 🔬🌍
https://loom.ly/CwagY2g
https://loom.ly/CwagY2g
June 25, 2025 at 12:03 PM
Introducing Andy Gao, postdoctoral fellow at John Curtin School of Medical Research, ANU! He will present his research on T & B cell collaboration in vaccination & parasite infection at #IUIS2025, with the presentation "Can a B cell eat a parasite? 🔬🌍
https://loom.ly/CwagY2g
https://loom.ly/CwagY2g
Reposted by Le Xiong
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
tinyurl.com
June 2, 2025 at 6:59 AM
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Congratulations !!!
I'm honoured to be recognized as one of the IUIS 2025 Rising Stars. Thanks to ASI for the nomination. Looking forward to seeing everyone in Vienna!
#IUIS2025 #RisingStars2025
iuis.org/news/meet-th...
#IUIS2025 #RisingStars2025
iuis.org/news/meet-th...
Meet the IUIS 2025 Rising Stars! » IUIS
The International Union of Immunological Societies (IUIS), together with its Early Career Committee, is delighted to announce the outstanding researchers selected as the IUIS 2025 Rising Stars: This…
iuis.org
June 17, 2025 at 7:17 AM
Congratulations !!!
Reposted by Le Xiong
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.
Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
May 19, 2025 at 1:41 AM
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.
Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
Excited to see our work published on @cp-immunity.bsky.social.
Also shared by a nice commentary. really like the last sentence:
“Not all fuel nourishes; some, once ignited, may burn beyond control.”
Also shared by a nice commentary. really like the last sentence:
“Not all fuel nourishes; some, once ignited, may burn beyond control.”
May 18, 2025 at 10:53 PM
Excited to see our work published on @cp-immunity.bsky.social.
Also shared by a nice commentary. really like the last sentence:
“Not all fuel nourishes; some, once ignited, may burn beyond control.”
Also shared by a nice commentary. really like the last sentence:
“Not all fuel nourishes; some, once ignited, may burn beyond control.”
Reposted by Le Xiong
#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut
microbial and immune environment, disrupting tissue homeostasis. IL-22 production
by group 3 innate lymphoid cells (I...
www.cell.com
April 19, 2025 at 2:56 PM
#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!
Reposted by Le Xiong
Future vaccines a step closer. Research from @groomlab.bsky.social, @benjbroom.bsky.social and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination.
Published in @jem.org
www.wehi.edu.au/news/vaccine...
Published in @jem.org
www.wehi.edu.au/news/vaccine...
May 7, 2025 at 11:51 PM
Future vaccines a step closer. Research from @groomlab.bsky.social, @benjbroom.bsky.social and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination.
Published in @jem.org
www.wehi.edu.au/news/vaccine...
Published in @jem.org
www.wehi.edu.au/news/vaccine...
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Online now: Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (ILC3s) is impaired, compromising gut barrier integrity. Saturated fatty acids intrinsically suppress ILC3 function, reducing their ability to control gut inflammation.
dlvr.it
April 15, 2025 at 1:25 AM
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Reposted by Le Xiong
Happy one week of my @jem.org paper!
Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
March 17, 2025 at 10:42 AM
Happy one week of my @jem.org paper!
Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
Reposted by Le Xiong
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...
March 10, 2025 at 4:18 PM
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...