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Reposted by Max Mahe

Pierre-François Lenne @pflenne.bsky.social · Jul 31

Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!

Development @dev-journal.bsky.social · Jul 29

Explant elongation initiates in the epithelium

A Research Highlight showcasing new work from @katiabarrett.bsky.social, Shalabh Anand, Virginie Thome, Laurent Kodjabachian, @merkellab.bsky.social, @pflenne.bsky.social

journals.biologists.com/dev/article/...

Fig. 2. Elongation behaviors of isolated and recombined explants in different conditions. (A) Table of isolation and recombined tissue experiments. Tissues are isolated with Activin or not and tested for elongation in isolation or recombined. This yields a total of eight conditions. (B-C′) Isolated mesenchyme and epithelial tissue experiments and their respective aspect ratio plots. N=5. (D-G′) Recombination experiments and their respective plots. Data are mean±s.d. N=5 for all conditions. Scale bars: 100 µm

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Eric Topol @erictopol.bsky.social · Jul 25

The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures

A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

www.cell.com

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Umut Kilik @umut-kilik.bsky.social · Jul 24

🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves

Camp Lab @graycamplab.bsky.social · Jul 24

Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11

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Camp Lab @graycamplab.bsky.social · Jul 24

Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11

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Eric Topol @erictopol.bsky.social · Jul 23

The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model
www.nature.com/articles/s41...

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Snippert lab @hugosnippert.bsky.social · Jul 23

🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9

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Max Mahe @maxmmahe.bsky.social · Jul 19

Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social

www.science.org/doi/10.1126/...

Recent evolution of the developing human intestine affects metabolic and barrier functions

Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human ...

www.science.org

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Waggoner Lab @labwaggoner.bsky.social · Jul 17

Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...

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Hsiu-Chuan Lin @hsiuchuanlin.bsky.social · Jul 12

My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · Jul 18

Pathology-oriented multiplexing enables integrative disease mapping @nature.com
www.nature.com/articles/s41...

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Fillip Port @crisprflydesign.bsky.social · Jul 17

Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells.

www.nature.com/articles/s41...

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) - Nature Communications

Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR screening in Drosophila and gen...

www.nature.com

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Fabian Theis @fabiantheis.bsky.social · Jul 3

New OpenProblems paper out! 📝

Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods.

Excited about transparent, evolving best practices for the field!

🔗 www.nature.com/articles/s41...

Defining and benchmarking open problems in single-cell analysis - Nature Biotechnology

Nature Biotechnology - Defining and benchmarking open problems in single-cell analysis

www.nature.com

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BaCell3D @bacell3d.bsky.social · Jun 25

We are very excited to close this years meeting with a keynote talk by Prof Jason Spence from @umich.edu. Understanding human lung development with bud tip, airway and Alveolar type2 (AT2)organoids. Unexpected transcriptional heterogeneity found in early postnatal AT2 cells occupying distinct niches

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Alexandra Delbot @alexandradelbot.bsky.social · Jun 24

Episode 2️⃣ Comment la souris est devenue le modèle par excellence ? Les souris représentent près de 70 % des animaux utilisés en laboratoire. Comment expliquer ce choix ? S'est-il imposé dès le début de l'expérimentation animale ? Quelles sont les limites d’un tel modèle ?
Avec Jean-Gaël Barbara 🐁

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Bertie Gottgens @bertiegottgens.bsky.social · Jun 24

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

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Jain_Akanksha_ @akanksha-jain.bsky.social · Jun 23

@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!

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BaCell3D @bacell3d.bsky.social · Jun 21

We’re all set!

With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.

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Esteban Hoijman @estebanhoijman.bsky.social · Jun 18

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...

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Nature @nature.com · Jun 16

The long-term goal is to grow human organs that can be harvested for transplantation

https://go.nature.com/3ST2BN7

Mice with human cells developed using ‘game-changing’ technique

Human cells injected into amniotic fluid find their way into fetal mouse organs.

go.nature.com

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James Briscoe @jamesbriscoe.bsky.social · Jun 10

New work on dynamics of morphogen signaling:

Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input

Morphogen signalling dynamics + GRN for tissue patterning

www.biorxiv.org/content/10.1...

Rapid transcriptional response to a dynamic morphogen by time integration

During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...

www.biorxiv.org

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Cell Stem Cell @cp-cellstemcell.bsky.social · Jun 9

3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation

Yu and his colleagues present a 3D spatial transcriptomic map of a CS9 human embryo, investigating several key developmental events during this critical stage of body patterning.

dlvr.it

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Eric Topol @erictopol.bsky.social · May 18

This week's genome editing triumph is a big deal.
Here's why
erictopol.substack.com/p/the-first-...

Multiple headlines about the first CRISPR 2.0 personalized genome editing and photo of the baby treated

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Max Mahe @maxmmahe.bsky.social · Apr 28

🚀 Ouverture des pré-inscriptions ! 🚀

Rejoignez-nous à Nantes pour l’École Thématique Organoïdes 2025 🧬 Découvrez notre pré-programme complet !

⚠️ Places limitées – La pré-inscription est indispensable pour participer.

📋 Plus d’infos et pré-inscription ici : organoides.sciencesconf.org

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GdR ImaBio @gdrimabio.bsky.social · May 11

#Organoïdes2025 - École Thématique 2025 du #GDR_Organoïdes à #Nantes,
📅 7-11 Juillet 2025

Inscriptions ouvertes : c'est l'occasion de se former, réseauter & explorer les défis de demain 🧫🔬❤️

🔗 organoides.sciencesconf.org

@ferrandlab.bsky.social @cnrs.fr @inserm.fr @insermgrandouest.bsky.social

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Camp Lab @graycamplab.bsky.social · May 12

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social

An integrated transcriptomic cell atlas of human endoderm-derived organoids - Nature Genetics

The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...

nature.com

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