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Reposted by Naomichi Takemata

Stephan Gruber @gruberlab.bsky.social · 18h

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

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Reposted by Naomichi Takemata

Géraldine Laloux @lalouxlab.bsky.social · 15d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Naomichi Takemata @naomichitakemata.bsky.social · 27d

Thank you to @tamarabasta.bsky.social for hosting my visit to I2BC @i2bcparissaclay.bsky.social in Paris! I truly enjoyed the inspiring scientific interactions and the beauty of the city.

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Stephan Gruber @gruberlab.bsky.social · Sep 5

Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...

With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:

Wadjet—Keeping a watchful eye on circular DNA.

www.cell.com/structure/fu...

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Reposted by Naomichi Takemata

Shiori Iida @shiori-iida.bsky.social · Aug 28

Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing

Full story & movies👇

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Aug 28

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...

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Mart Krupovic @mkrupovic.bsky.social · Aug 18

Check out our paper in PLoS Genetics with @umbertorosani.bsky.social and Marco Gerdol on the highly dynamic pangenome of basal chordates. It is enriched in defence and immunity genes (like in prokaryotes) and follows Mendelian inheritanceis rules. @plos.org journals.plos.org/plosgenetics...

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Tobias Warnecke @tobiaswarnecke.bsky.social · Aug 14

Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it?

Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...

Archaea produce peptidoglycan hydrolases that kill bacteria

Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...

journals.plos.org

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Bungo Akiyoshi @bungoakiyoshi.bsky.social · Aug 6

My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...

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Reposted by Naomichi Takemata

Takashi Akera Lab @takashiakeralab.bsky.social · Jul 27

📣Huge congrats to our postdoc, Takaya Totsuka, on his new paper @currentbiology.bsky.social 🎉 He found that Ca2+ oscillations regulate oocyte spindle rotation! 🐭The project started during his PhD with Prof. Miho Ohsugi.

Free link: authors.elsevier.com/c/1lUqk3QW8S...

authors.elsevier.com

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Reposted by Naomichi Takemata

Géraldine Laloux @lalouxlab.bsky.social · Jul 25

#MicroSky Summer read!

Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛

How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social

www.sciencedirect.com/science/arti...

Strategies and mechanisms of contact-dependent predation in bacteria

Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…

www.sciencedirect.com

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Naomichi Takemata @naomichitakemata.bsky.social · Jul 23

Congrats!!!

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Reposted by Naomichi Takemata

Daniela Barillà @danielabarilla.bsky.social · Jul 22

And the story is published now!🍾
www.nature.com/articles/s41...

Open access link: rdcu.be/exnOc

Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social

Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏
#microsky #archaeasky

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Reposted by Naomichi Takemata

Takashi Akera Lab @takashiakeralab.bsky.social · Jul 15

🚨Our latest work on selfish centromeres is published @currentbiology.bsky.social 🐭🧬We found that the spindle checkpoint contributes to non-Mendelian segregation! Huge congrats to our lab manager, Zaak Walton, who led the project🎉

Free link:
authors.elsevier.com/a/1lQzN3QW8S...

authors.elsevier.com

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Reposted by Naomichi Takemata

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Jul 10

Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social

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Anton Goloborodko @golobor.bsky.social · Jul 15

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
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Dame lab at Leiden University @damelab.bsky.social · Jul 10

I am pleased to share our new review on the role of bacterial nucleoid-aasociated proteins in mediating responses to changes in environment. Important: some NAPs can directly ‘sense’ physico-chemical changes. www.sciencedirect.com/science/arti... @pingzhuangge.bsky.social

The role of nucleoid-associated proteins in mediating responses to environmental changes

Bacteria face diverse environmental challenges, such as changes in temperature, pH, and osmolarity, and exposure to antibiotics, which necessitate ada…

www.sciencedirect.com

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Tung Le @tunglejic.bsky.social · Jul 10

Fantastic opportunity to start your independent career at the JIC here. Great startup package. Repost = nice. Thank you!!!

Susan Schlimpert @s-lab.bsky.social · Jul 10

New Independent Fellowship position in Microbiology to launch your lab in our department @johninnescentre.bsky.social (UK). We are conducting a broad search in the area of plant-associated microbial interactions. Message me if you have any questions.

Apply here: www.jic.ac.uk/vacancies/in...

Independent Fellowship in Plant-Associated Microbial Interactions | John Innes Centre

An exciting opportunity for an Independent Fellowship in Plant-Associated Microbial Interactions has arisen at the John Innes Centre. To read the full job description for this role…

www.jic.ac.uk

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Takashi Fukaya @fukayalab.bsky.social · Jul 6

Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!!

www.sciencedirect.com/journal/jour...

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Aaron Straight @astraight.bsky.social · Jun 20

New preprint from Kelsey Fryer in the lab using ChAR-seq to identify RNAs that are bound to human centromeres. Lots of surprises! #centromere #RNA www.biorxiv.org/content/10.1...

www.biorxiv.org

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · Jun 18

Our new review paper is out@JMB!🧬
@katsuminami.bsky.social‬ @semeigazin.bsky.social‬ ‪@kakonakazato.bsky.social‬ discuss DNA accessibility in euchromatin and heterochromatin of live cells.
Free access: authors.elsevier.com/a/1lHgb54HFZ...
Also check our previous work: www.science.org/doi/10.1126/...

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Stephan Gruber @gruberlab.bsky.social · Jun 16

This reveals parallels with DNA end protection in eukaryotes and highlights the challenges of having linear chromosomes as well as functional repair of DNA double strand break.

www.biorxiv.org/cgi/content/...

www.biorxiv.org

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Bungo Akiyoshi @bungoakiyoshi.bsky.social · Jun 10

Published now. doi.org/10.1242/jcs....

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Hiro Imachi @hiro-imachi.bsky.social · Jun 4

Would you like to work with us?
At JAMSTEC, we are recruiting postdoctoral researchers through the Young Research Fellow program.
This program allows fellows to independently pursue their own research projects.
www.jamstec.go.jp/recruit/e/jy...

JAMSTEC Young Research Fellow (JYRF) | JAMSTEC - JAPAN AGENCY FOR MARINE-EARTH SCIENCE AND TECHNOLOGY

JAMSTEC Young Research Fellow (JYRF)

www.jamstec.go.jp

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Kyogo Kawaguchi @kyogok.bsky.social · Jun 5

Exciting new study from Iwasaki lab, led by Kotaro @ktomuro.bsky.social & Yuichi @u1-7no.bsky.social, that I was lucky to be part of! A new method reveals many mRNAs are locally translated. Too much for one tweet—check it out: www.biorxiv.org/content/10.1...

www.biorxiv.org

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Naomichi Takemata @naomichitakemata.bsky.social · Jun 6

Congrats to the team!

Tominaga K. (tomiken) @pacyc184.bsky.social · Jun 5

An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins | Nature Communications https://www.nature.com/articles/s41467-025-60618-3

An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins - Nature Communications

The mechanisms that regulate the initiation of DNA replication in archaea are poorly understood. Here, Dhanaraju et al. identify a sequence element and its interacting protein required for DNA replication initiation in the model archaeon Sulfolobus islandicus.

www.nature.com

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