Tertiary lymphoid structures (TLS) and B cell infiltration are strong predictors of immunotherapy success across cancers, including triple-negative breast cancer (TNBC). However, immune-cold TNBCs oft...

Chris Biggar, a 34-year-old from Ohio, had just landed his dream job working in R&D when he was diagnosed with stage 4 colon cancer. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are enrolled […]

When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

Katie Couric is trading her hospital gown for "great jeans." The journalist parodied Sydney Sweeney's jeans ad in a PSA for colon cancer screenings.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 September 2025; doi:10.1038/s41575-025-01117-0Diet modulates not only gastrointestinal cancer risk but also survivorship, providing an opportunity to improve cancer-related outcomes and quality of life through suitable dietary and lifestyle interventions in survivors of cancer. This Comment summarizes the evidence and ongoing trials investigating diet in gastrointestinal cancer survival, including potential underlying mechanisms and future research directions.

The etiology of early-onset colorectal cancer needs to be understood to tackle rising incidence

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

LLM “tended to sacrifice accuracy for simplicity” when writing news briefs.

Triple-negative breast cancer (TNBC) is characterized by high risks of relapse or metastatic disease. Mattavelli et al. identify a chemokine axis that recruits immunosuppressive monocytes to tumor-draining lymph nodes. By co-targeting this recruitment, the TNBC response to immune checkpoint blockade is augmented and metastasis to the lung is reduced.

To combat surging rates of early-onset GI cancer, experts suggest a new approach combining lower screening thresholds and addressing modifiable risk factors.

The functional state of tumor-infiltrating lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. Rivadeneira et al. demonstrate that mitochondrial ROS accumulation induces oxidative damage at telomeres, which is sufficient to drive T cell dysfunction. Neutralizing ROS at telomeres mitigates T cell dysfunction and improves cellular therapies.

The American Society for Microbiology released a joint statement calling for the resignation of HHS Secretary Robert F. Kennedy Jr.