Paul Beach
@pbeach.bsky.social
Autonomic and movement disorders neurologist and neuroscientist 🧠
Emory University, Atlanta, GA
Interoception enthusiast 🫀🫁
Emory University, Atlanta, GA
Interoception enthusiast 🫀🫁
Coeurleophiles and autonomic fanatics, rejoice! I bring you a paper combining both.
Here, we show that orthostatic hypotension must accounted for if attempting to utilize locus coeruleus integrity (with NM-MRI) in the DDx of #Parkinson's and #MultipleSystemAtrophy.
link.springer.com/article/10.1...
Here, we show that orthostatic hypotension must accounted for if attempting to utilize locus coeruleus integrity (with NM-MRI) in the DDx of #Parkinson's and #MultipleSystemAtrophy.
link.springer.com/article/10.1...
Locus coeruleus degeneration is associated with orthostatic hypotension in Parkinson’s disease and multiple system atrophy - Clinical Autonomic Research
Purpose We compared locus coeruleus (LC) structural integrity, as measured by neuromelanin-sensitive magnetic resonance imaging (NM-MRI), between patients with Parkinson’s disease (PD) and those with ...
link.springer.com
October 31, 2025 at 12:45 PM
Coeurleophiles and autonomic fanatics, rejoice! I bring you a paper combining both.
Here, we show that orthostatic hypotension must accounted for if attempting to utilize locus coeruleus integrity (with NM-MRI) in the DDx of #Parkinson's and #MultipleSystemAtrophy.
link.springer.com/article/10.1...
Here, we show that orthostatic hypotension must accounted for if attempting to utilize locus coeruleus integrity (with NM-MRI) in the DDx of #Parkinson's and #MultipleSystemAtrophy.
link.springer.com/article/10.1...
Reposted by Paul Beach
Excited to share this comprehensive review on supine hypertension led by brilliant resident, Sally Zimmerman!
@bidmcreseach.bsky.social
@rueyhu.bsky.social
@pbeach.bsky.social
Supine hypertension and cardiovascular disease: controversies and advances
www.tandfonline.com/doi/full/10....
@bidmcreseach.bsky.social
@rueyhu.bsky.social
@pbeach.bsky.social
Supine hypertension and cardiovascular disease: controversies and advances
www.tandfonline.com/doi/full/10....
Supine hypertension and cardiovascular disease: controversies and advances
Elevated blood pressure is one of the most important risk factors for cardiovascular disease (CVD). Despite blood pressure being historically measured in the supine position prior to the 20th centu...
www.tandfonline.com
September 4, 2025 at 9:25 AM
Excited to share this comprehensive review on supine hypertension led by brilliant resident, Sally Zimmerman!
@bidmcreseach.bsky.social
@rueyhu.bsky.social
@pbeach.bsky.social
Supine hypertension and cardiovascular disease: controversies and advances
www.tandfonline.com/doi/full/10....
@bidmcreseach.bsky.social
@rueyhu.bsky.social
@pbeach.bsky.social
Supine hypertension and cardiovascular disease: controversies and advances
www.tandfonline.com/doi/full/10....
Can you figure out the etiology of this patient's autonomic failure?
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Clinical Reasoning: A 72-Year-Old Man With Progressive Pan-Dysautonomia | Neurology
Dysautonomia is a common clinical feature among many central and peripheral neurologic
disorders. Evaluation of patients with dysautonomia can be challenging in the absence
of a previously established...
www.neurology.org
August 8, 2025 at 6:18 PM
Can you figure out the etiology of this patient's autonomic failure?
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Do YOU know the nuances of evaluating and managing cardiovascular autonomic failure in synucleinopathy patients? Check out this hot off the press review by my good friend Abhi Lenka and I, now published in @movedisorder.bsky.social's Clinical Practice journal.
doi.org/10.1002/mdc3...
doi.org/10.1002/mdc3...
Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies
Background Autonomic dysfunction is a common feature of synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and pure autonomic failure...
doi.org
August 8, 2025 at 2:27 PM
Do YOU know the nuances of evaluating and managing cardiovascular autonomic failure in synucleinopathy patients? Check out this hot off the press review by my good friend Abhi Lenka and I, now published in @movedisorder.bsky.social's Clinical Practice journal.
doi.org/10.1002/mdc3...
doi.org/10.1002/mdc3...
Reposted by Paul Beach
A quick update re NIH and NSF terminated grant tracking:
Grant Watch has a new name!
We're now called **Grant Witness**
You can find us at grant-witness.us
Please update your bookmarks and spread the word! 🙏
(And no, this wasn't our preference, but trademarks are a thing. 🤦♂️🤷♂️)
Grant Watch has a new name!
We're now called **Grant Witness**
You can find us at grant-witness.us
Please update your bookmarks and spread the word! 🙏
(And no, this wasn't our preference, but trademarks are a thing. 🤦♂️🤷♂️)
July 29, 2025 at 6:05 PM
A quick update re NIH and NSF terminated grant tracking:
Grant Watch has a new name!
We're now called **Grant Witness**
You can find us at grant-witness.us
Please update your bookmarks and spread the word! 🙏
(And no, this wasn't our preference, but trademarks are a thing. 🤦♂️🤷♂️)
Grant Watch has a new name!
We're now called **Grant Witness**
You can find us at grant-witness.us
Please update your bookmarks and spread the word! 🙏
(And no, this wasn't our preference, but trademarks are a thing. 🤦♂️🤷♂️)
- Exenetide had promise as a disease modifying agent in #Parkinsonsdisease. How about #MSA?
- Single center, *open-label* 48 wk trial lower change in UMSARS score over tme.
- Treatment had no impact on objective findings.
- Placebo/bias effects highly likely.
onlinelibrary.wiley.com/doi/10.1002/...
- Single center, *open-label* 48 wk trial lower change in UMSARS score over tme.
- Treatment had no impact on objective findings.
- Placebo/bias effects highly likely.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
July 30, 2025 at 4:56 PM
- Exenetide had promise as a disease modifying agent in #Parkinsonsdisease. How about #MSA?
- Single center, *open-label* 48 wk trial lower change in UMSARS score over tme.
- Treatment had no impact on objective findings.
- Placebo/bias effects highly likely.
onlinelibrary.wiley.com/doi/10.1002/...
- Single center, *open-label* 48 wk trial lower change in UMSARS score over tme.
- Treatment had no impact on objective findings.
- Placebo/bias effects highly likely.
onlinelibrary.wiley.com/doi/10.1002/...
I am 3 years out of formal training in movement disorders - a two year fellowship - and I only just heard a coherent rationale for why we refer to certain diagnoses as “essential.”
Thanks to Bsky-less podcast from Practical Neurology.
Thanks to Bsky-less podcast from Practical Neurology.
July 26, 2025 at 7:09 PM
I am 3 years out of formal training in movement disorders - a two year fellowship - and I only just heard a coherent rationale for why we refer to certain diagnoses as “essential.”
Thanks to Bsky-less podcast from Practical Neurology.
Thanks to Bsky-less podcast from Practical Neurology.
The heartbeat evoked potential is modulated by fluctuations in blood pressure, as measured during paced breathing and postural changes.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Changes in heartbeat-evoked potentials reflect changes in blood pressure | Journal of Neurophysiology | American Physiological Society
The heartbeat-evoked potential (HEP) is a growingly used electrophysiological method to study cardiac interoception; however, cardiovascular influences on these responses are not fully understood. In ...
journals.physiology.org
July 24, 2025 at 6:20 PM
The heartbeat evoked potential is modulated by fluctuations in blood pressure, as measured during paced breathing and postural changes.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Chronic low thoracic epidural spinal cord stimulation may work in #Parkinsons with severe orthostatic hypotension.
Previously, a different group showed its feasibility in a patient with multiple system atrophy. Many of us thought it may not work in PD.
www.brainstimjrnl.com/article/S193...
Previously, a different group showed its feasibility in a patient with multiple system atrophy. Many of us thought it may not work in PD.
www.brainstimjrnl.com/article/S193...
Epidural spinal cord stimulation for the management of orthostatic hypotension in Parkinson’s disease: A case report
Parkinson's disease (PD) therapies predominantly target motor symptoms via dopaminergic
agents and deep brain stimulation (DBS), yet critical non-motor symptoms like orthostatic
hypotension (OH) remai...
www.brainstimjrnl.com
July 23, 2025 at 7:04 PM
Chronic low thoracic epidural spinal cord stimulation may work in #Parkinsons with severe orthostatic hypotension.
Previously, a different group showed its feasibility in a patient with multiple system atrophy. Many of us thought it may not work in PD.
www.brainstimjrnl.com/article/S193...
Previously, a different group showed its feasibility in a patient with multiple system atrophy. Many of us thought it may not work in PD.
www.brainstimjrnl.com/article/S193...
Cerebellar #multiplesystematrophy #MSA & cognition.
Huge number of patients (210).
- 24.8% of patients had cognitive impairment on neuropsych tests of language, memory and processing speed
- *NO* association with OH or HTN
- ⬆️risk w/age, MRI hot-cross bun sign
journals.sagepub.com/doi/full/10....
Huge number of patients (210).
- 24.8% of patients had cognitive impairment on neuropsych tests of language, memory and processing speed
- *NO* association with OH or HTN
- ⬆️risk w/age, MRI hot-cross bun sign
journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
July 21, 2025 at 3:44 PM
Cerebellar #multiplesystematrophy #MSA & cognition.
Huge number of patients (210).
- 24.8% of patients had cognitive impairment on neuropsych tests of language, memory and processing speed
- *NO* association with OH or HTN
- ⬆️risk w/age, MRI hot-cross bun sign
journals.sagepub.com/doi/full/10....
Huge number of patients (210).
- 24.8% of patients had cognitive impairment on neuropsych tests of language, memory and processing speed
- *NO* association with OH or HTN
- ⬆️risk w/age, MRI hot-cross bun sign
journals.sagepub.com/doi/full/10....
#interoception banger alert for new work by @mtsakiris.bsky.social and team.
More evidence on how timing of cardiac phase (systole/diastole) impacts cognitive processes - facilitation of alerting.
www.sciencedirect.com/science/arti...
More evidence on how timing of cardiac phase (systole/diastole) impacts cognitive processes - facilitation of alerting.
www.sciencedirect.com/science/arti...
The heart in attention: evidence for cardiac phase effects in alerting but not executive control
Across two experiments, we examined the role of phasic cardiac fluctuations – whether the heart contracts (systole) or relaxes (diastole) – on two att…
www.sciencedirect.com
July 19, 2025 at 9:49 AM
#interoception banger alert for new work by @mtsakiris.bsky.social and team.
More evidence on how timing of cardiac phase (systole/diastole) impacts cognitive processes - facilitation of alerting.
www.sciencedirect.com/science/arti...
More evidence on how timing of cardiac phase (systole/diastole) impacts cognitive processes - facilitation of alerting.
www.sciencedirect.com/science/arti...
Reduced REM sleep density in #Parkinsondisease linked to worse gait. CR levodopa at bedtime increased REM density! Very interesting.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
REM density in Parkinson’s disease: association with motor, cognitive, autonomic function, and dopaminergic medication - npj Parkinson's Disease
npj Parkinson's Disease - REM density in Parkinson’s disease: association with motor, cognitive, autonomic function, and dopaminergic medication
www.nature.com
July 18, 2025 at 1:00 PM
Reduced REM sleep density in #Parkinsondisease linked to worse gait. CR levodopa at bedtime increased REM density! Very interesting.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Paul Beach
It’s a good thing Congress isn’t alive to see this
June 22, 2025 at 12:47 AM
It’s a good thing Congress isn’t alive to see this
Very glad to share this *just* published viewpoint by myself, @abhilenka.bsky.social @spjuraschek.bsky.social @jeanieparkmdms.bsky.social and media-less Cameron in 'Clinical Autonomic Research'
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A reset on our reclined position—a call to prioritize neurogenic supine hypertension in the synucleinopathies - Clinical Autonomic Research
Clinical Autonomic Research -
link.springer.com
June 18, 2025 at 3:29 PM
Very glad to share this *just* published viewpoint by myself, @abhilenka.bsky.social @spjuraschek.bsky.social @jeanieparkmdms.bsky.social and media-less Cameron in 'Clinical Autonomic Research'
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Paul Beach
When Americans raised concerns about RFK Jr.'s anti-vaccine views, he said he was "not gonna take away vaccines from anybody."
But now he's taking them away from millions of mommas and babies.
Vaccine recommendations should be based on science, not RFK Jr.'s political agenda.
But now he's taking them away from millions of mommas and babies.
Vaccine recommendations should be based on science, not RFK Jr.'s political agenda.
May 27, 2025 at 6:30 PM
When Americans raised concerns about RFK Jr.'s anti-vaccine views, he said he was "not gonna take away vaccines from anybody."
But now he's taking them away from millions of mommas and babies.
Vaccine recommendations should be based on science, not RFK Jr.'s political agenda.
But now he's taking them away from millions of mommas and babies.
Vaccine recommendations should be based on science, not RFK Jr.'s political agenda.
This is why B12 is always on the differential for autonomic failure.
"Subacute Combined Degeneration Presenting
With Prominent Autonomic Symptoms 12 Years
After Total Gastrectomy: A Case Report"
assets.cureus.com/uploads/case...
"Subacute Combined Degeneration Presenting
With Prominent Autonomic Symptoms 12 Years
After Total Gastrectomy: A Case Report"
assets.cureus.com/uploads/case...
assets.cureus.com
May 16, 2025 at 2:30 PM
This is why B12 is always on the differential for autonomic failure.
"Subacute Combined Degeneration Presenting
With Prominent Autonomic Symptoms 12 Years
After Total Gastrectomy: A Case Report"
assets.cureus.com/uploads/case...
"Subacute Combined Degeneration Presenting
With Prominent Autonomic Symptoms 12 Years
After Total Gastrectomy: A Case Report"
assets.cureus.com/uploads/case...
The excellent @vanderbilt.edu #autonomic team coming through with another great study demonstrating that post-prandial hypotension is more common/severe in autonomic failure due to a peripheral etiology.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure - Clinical Autonomic Research
Purpose Postprandial hypotension (PPH) defined as a decrease in systolic blood pressure of more than 20 mmHg within 2 h post meal is prevalent in patients with autonomic failure and is associated with...
link.springer.com
May 16, 2025 at 12:34 PM
The excellent @vanderbilt.edu #autonomic team coming through with another great study demonstrating that post-prandial hypotension is more common/severe in autonomic failure due to a peripheral etiology.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Paul Beach
He's literally holding a red lightsaber.
May 5, 2025 at 1:21 AM
He's literally holding a red lightsaber.
Reposted by Paul Beach
‘Kennedy told reporters that there were "many, many good ways to treat measles and doctors need to know that and to know those methods.’
One problem; there is no treatment for measles. Signed, a doctor who’s been forced to deal with measles because of this stupid fraud.
One problem; there is no treatment for measles. Signed, a doctor who’s been forced to deal with measles because of this stupid fraud.
RFK Jr. asks CDC for new measles treatment guidance amid his unfounded claims
Kennedy claimed that drugs like budesonide and clarithromycin "have been shown very effective" for measles, but doctors say they don't fight the infection itself.
www.cbsnews.com
May 2, 2025 at 3:11 AM
‘Kennedy told reporters that there were "many, many good ways to treat measles and doctors need to know that and to know those methods.’
One problem; there is no treatment for measles. Signed, a doctor who’s been forced to deal with measles because of this stupid fraud.
One problem; there is no treatment for measles. Signed, a doctor who’s been forced to deal with measles because of this stupid fraud.
Reposted by Paul Beach
No such thing as ‘validation’ of the 'neuronal α-synuclein disease integrated staging system' (NSD-ISS) for #Parkinsons.
It uses αSyn-SAA positivity to anchor an “S-D-G” (Synuclein–Dopamine dysfunction–Genetics) model. Does it hold up? (1/4)
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
It uses αSyn-SAA positivity to anchor an “S-D-G” (Synuclein–Dopamine dysfunction–Genetics) model. Does it hold up? (1/4)
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Neuronal α‐Synuclein Disease Stage Progression over 5 Years
Background Neuronal α-synuclein disease (NSD) is defined by the presence of an in vivo biomarker of neuronal alpha-synuclein (n-asyn) pathology. The NSD integrated staging system (NSD-ISS) for resea...
movementdisorders.onlinelibrary.wiley.com
May 1, 2025 at 12:32 AM
No such thing as ‘validation’ of the 'neuronal α-synuclein disease integrated staging system' (NSD-ISS) for #Parkinsons.
It uses αSyn-SAA positivity to anchor an “S-D-G” (Synuclein–Dopamine dysfunction–Genetics) model. Does it hold up? (1/4)
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
It uses αSyn-SAA positivity to anchor an “S-D-G” (Synuclein–Dopamine dysfunction–Genetics) model. Does it hold up? (1/4)
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Paul Beach
The science is clear: the more you listen to RFK, the stupider you get. Many scientists are saying this. #Trumpland #TrumpLies
RFK Jr: "We found that there's a direct inverse correlation between fluoride exposure and low IQ in children. So the more you get, the stupider you are."
April 30, 2025 at 6:08 PM
The science is clear: the more you listen to RFK, the stupider you get. Many scientists are saying this. #Trumpland #TrumpLies
Reposted by Paul Beach
Insightful combination of EEG and iEEG in a patient with epilepsy to study the effects of taVNS on heartbeat-evoked potentials (HEP) in the insula. taVNS enhanced HEPs, but the paper does not say the interaction (vs. sham) was not significant. #neuroskyence
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
April 21, 2025 at 7:29 AM
Insightful combination of EEG and iEEG in a patient with epilepsy to study the effects of taVNS on heartbeat-evoked potentials (HEP) in the insula. taVNS enhanced HEPs, but the paper does not say the interaction (vs. sham) was not significant. #neuroskyence
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Paul Beach
Autism is not a disease and these kids are not damaged, despite what HHS Secretary Kennedy says.
April 16, 2025 at 8:38 PM
Autism is not a disease and these kids are not damaged, despite what HHS Secretary Kennedy says.
Reposted by Paul Beach
As a biologist, I'm appalled at pride the White House takes in willful ignorance.
In yesterday's executive order about NPR and PBS, their first example of "the trash that passes for `news' at NPR and PBS" is the statement that "banana slugs are hermaphrodites."
But this is unequivocal fact.
In yesterday's executive order about NPR and PBS, their first example of "the trash that passes for `news' at NPR and PBS" is the statement that "banana slugs are hermaphrodites."
But this is unequivocal fact.
The NPR, PBS Grift Has Ripped Us Off for Too Long
For years, American taxpayers have been on the hook for subsidizing National Public Radio (NPR) and the Public Broadcasting Service (PBS), which spread
www.whitehouse.gov
April 15, 2025 at 9:34 PM
As a biologist, I'm appalled at pride the White House takes in willful ignorance.
In yesterday's executive order about NPR and PBS, their first example of "the trash that passes for `news' at NPR and PBS" is the statement that "banana slugs are hermaphrodites."
But this is unequivocal fact.
In yesterday's executive order about NPR and PBS, their first example of "the trash that passes for `news' at NPR and PBS" is the statement that "banana slugs are hermaphrodites."
But this is unequivocal fact.
Reposted by Paul Beach
Not disagreeing. This is a good piece. It offers some grounded and useful advice for how to advance free thought and good values in today’s autocratic America.
But wow is it depressing. This is where we are at now. An autocratic America.
Still, we will fight on together.
But wow is it depressing. This is where we are at now. An autocratic America.
Still, we will fight on together.
Not sure of the paywall status with this but really enjoyed this piece in The New Yorker, assembling a practical guide to remaining fully American, even under Trump, w interviews from global dissident movements. Good stuff. www.newyorker.com/news/the-wee...
So You Want to Be a Dissident?
A practical guide to courage in Trump’s age of fear.
www.newyorker.com
April 12, 2025 at 10:32 PM
Not disagreeing. This is a good piece. It offers some grounded and useful advice for how to advance free thought and good values in today’s autocratic America.
But wow is it depressing. This is where we are at now. An autocratic America.
Still, we will fight on together.
But wow is it depressing. This is where we are at now. An autocratic America.
Still, we will fight on together.