Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...

I know this is late, but one of the most important PC survival advances in recent years. Key conception. Check it out!

doi.org/10.1038/s415...
www.nature.com/articles/s41...

Just dropped! Complicated impacts of il21 on gc exit to memory. Kudos to @alidvorscek.bsky.social and Jesse Mulder!

IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...

Been looking forward to seeing this come out! Congrats and can't wait to read the preprint

HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung https://www.biorxiv.org/content/10.1101/2025.06.13.659476v1

it's easy to see that without basic operating societal structures and government trust in science, both conditions we are privileged to have in Australia, our efforts are rendered meaningless. Thinking of oppressed people the world over and hoping our discoveries hold meaning in the years to come.

This is a two-part post.

I am privileged to do tax-payer funded research into allergy cures and ways to improve vaccines. My goals are to improve people's lives, stability of the food supply and minimise risks of future pandemics. However,

🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations

Apply now 👉 tinyurl.com/Seilletlab

Vaccination in left arm, right arm, or both?? @labphan.bsky.social congrats and looking to you for the answer 😄

Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...

New Highlight of @cp-immunity.bsky.social paper by Nelson et al. @loyolachicago.bsky.social reporting that lung-resident IgG1+ memory B cells class-switch to IgE to mediate airway hypersensitivity in asthma
#immunosky #immunology #asthma

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.

@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

New preprint alert 🚨

My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.

For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...

As a first Bluesky post, I’m happy to share our latest publication @emboreports.org:
www.embopress.org/doi/full/10....
Led by Craig McKenzie, we used CRISPR-Cas9 gene editing to investigate how Syndecan-1 (CD138) and -4 (SDC4) influence B-cell development and activation.
#ImmunoSky #MonashUni

Cool germinal center acrobatics from Juhee Pae et al, check it out!

www.nature.com/articles/s41...

KLF2 expression in IgG plasma cells at their induction site regulates the migration program, say Wataru Ise, Takuya Koike, Tomohiro Kurosaki @osaka_univ_e and colleagues: buff.ly/41bbKEF

Team, this piece is great if you're interested in Abs! TLDR: GC-derived ASC maintain a proliferative burst post-differentiation proportional to affinity/help to explain overrepresentation of high affinity in PC despite differentiation from all affinities.
#immunosky

www.science.org/doi/10.1126/...

Prof Kjesten Wiig has been appointed Director of the Malaghan Institute as Professor Graham Le Gros continues in a leadership capacity as Deputy Chair of the Trust Board and advisor to the new Director @grahamlegros.bsky.social

Time for a reset...let's go!

go.bsky.app/8avwjYw

Wonderful to see the #immunology community growing here.

The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

And make the second one a bit more esoteric to refine the algorithm #Bcell #TFH #epitope #antibody #germinalcenter #plasmacell #idiotype #heteroclitic #anamnestic #Immunoglobulin #recrudescence

Let's keep this first post simple #Immunology