Rock Lab
@rocklabtb.bsky.social
Rock Lab @ Rockefeller University. Tuberculosis functional genomics.
Reposted by Rock Lab
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New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
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c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Reposted by Rock Lab
Sharing this article that I wrote with my husband, @jutraslab.bsky.social for @unbiasedscipod.bsky.social. Last week researchers reported what appears to be the first clearly documented fatality from alpha‑gal syndrome.
#Scicomm #tickbornediseases #alphagalsyndrome
#Scicomm #tickbornediseases #alphagalsyndrome
No, It’s Not “Just a Meat Allergy”: The Truth About Alpha-gal Syndrome
A 47-year-old pilot’s death after eating a hamburger reveals critical gaps in our understanding
open.substack.com
November 21, 2025 at 5:25 PM
Sharing this article that I wrote with my husband, @jutraslab.bsky.social for @unbiasedscipod.bsky.social. Last week researchers reported what appears to be the first clearly documented fatality from alpha‑gal syndrome.
#Scicomm #tickbornediseases #alphagalsyndrome
#Scicomm #tickbornediseases #alphagalsyndrome
Reposted by Rock Lab
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology
Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.
www.nature.com
November 13, 2025 at 9:44 PM
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rock Lab
With the Wilmanns lab @embl.org we reveal cryoEM structures of an essential, bifunctional acyl-CoA carboxylase from mycobacteria. @wertheimufscripps.bsky.social
This ~ 600 kDa enzyme is asymmetric, rotatory, has unusual stoichiometry, and unique E5 subunits.
www.biorxiv.org/content/10.1...
This ~ 600 kDa enzyme is asymmetric, rotatory, has unusual stoichiometry, and unique E5 subunits.
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 17, 2025 at 1:38 PM
With the Wilmanns lab @embl.org we reveal cryoEM structures of an essential, bifunctional acyl-CoA carboxylase from mycobacteria. @wertheimufscripps.bsky.social
This ~ 600 kDa enzyme is asymmetric, rotatory, has unusual stoichiometry, and unique E5 subunits.
www.biorxiv.org/content/10.1...
This ~ 600 kDa enzyme is asymmetric, rotatory, has unusual stoichiometry, and unique E5 subunits.
www.biorxiv.org/content/10.1...
Reposted by Rock Lab
Reposted by Rock Lab
Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): www.biorxiv.org/content/10.1...
Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species
Mycobacterium tuberculosis (Mtb) persists within macrophages, yet how different host species shape bacterial state remains poorly understood. Here, we directly compared the intracellular transcriptome...
www.biorxiv.org
November 17, 2025 at 6:20 AM
Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): www.biorxiv.org/content/10.1...
Reposted by Rock Lab
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
November 15, 2025 at 4:02 AM
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
Reposted by Rock Lab
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 9:57 PM
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Reposted by Rock Lab
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 30, 2025 at 3:21 AM
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by Rock Lab
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Rock Lab
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 9:47 PM
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
Ditto. Thanks for this Sarah. www.statnews.com/2025/10/06/g...
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
www.statnews.com
October 8, 2025 at 9:52 AM
Ditto. Thanks for this Sarah. www.statnews.com/2025/10/06/g...
Reposted by Rock Lab
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 7, 2025 at 4:10 PM
We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783
Reposted by Rock Lab
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 5, 2025 at 12:03 PM
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Reposted by Rock Lab
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Department of Microbiology | The University of Chicago
microbiology.uchicago.edu
October 6, 2025 at 5:32 PM
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Congratulations!
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as an axis of variation in host interaction. Underscoring this, variants in a regulator of a key virulence pathway are associated with increased transmission and drug resistance.
dlvr.it
September 30, 2025 at 11:03 PM
Congratulations!
Reposted by Rock Lab
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as an axis of variation in host interaction. Underscoring this, variants in a regulator of a key virulence pathway are associated with increased transmission and drug resistance.
dlvr.it
September 30, 2025 at 6:51 PM
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Reposted by Rock Lab
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted by Rock Lab
Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:
National Academy of Medicine to Present Hamburg Award to Carl F. Nathan for Seminal Discoveries That Improve Understanding of Innate Immunity - NAM
WASHINGTON — The National Academy of Medicine (NAM) today announced that Carl F. Nathan is the recipient of the 2025 David and Beatrix Hamburg Award for
nam.edu
September 26, 2025 at 7:23 PM
Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:
Very interesting, excited to see where this goes.
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 15, 2025 at 4:56 PM
Very interesting, excited to see where this goes.
Reposted by Rock Lab
We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine
August 20, 2025 at 7:41 PM
We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine
Reposted by Rock Lab
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below:
Faculty recruitment - Our Scientists
Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.
www.rockefeller.edu
August 20, 2025 at 3:13 PM
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below:
Reposted by Rock Lab
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
www.statnews.com
July 31, 2025 at 9:08 PM
Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut www.statnews.com/2025/07/31/n...
Congrats to all authors! Very cool mechanism. www.nature.com/articles/s41...
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
July 31, 2025 at 8:41 PM
Congrats to all authors! Very cool mechanism. www.nature.com/articles/s41...