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rouxlab.bsky.social
Roux Lab, Geneva
@rouxlab.bsky.social
3.2K followers 810 following 17 posts
A mix of physics and biology, understanding shapes in biology, from molecules to tissues.
http://www.orelrouxlab.org
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Reposted by Roux Lab, Geneva
pauguillamat.bsky.social
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.

@pnas.org @ub.edu

www.pnas.org/doi/10.1073/...

#ActiveMatter #Microfluidics #SoftMatter
Active nematic pumps | PNAS
Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alte...
www.pnas.org
November 12, 2025 at 7:20 PM
rouxlab.bsky.social
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
embojournal.org The EMBO Journal @embojournal.org · 11d
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Reposted by Roux Lab, Geneva
membramics-lab.bsky.social
Etienne @membramics-lab.bsky.social is very happy to visit @rouxlab.bsky.social in Geneva! great people, great projects, good memories...
November 7, 2025 at 10:40 AM
Reposted by Roux Lab, Geneva
biology-unige.bsky.social
‪
Congratulations @centriolelab.bsky.social @dudinlab.bsky.social and @gautamdey.bsky.social for your publication in @cp-cell.bsky.social: Charting the landscape of #cytoskeletal diversity in #microbial eukaryotes #Expansion #Microscopy @sciencesunige.bsky.social
www.unige.ch/medias/en/20...
November 3, 2025 at 1:34 PM
Reposted by Roux Lab, Geneva
juanmagararc.bsky.social
*ALL*source data and Python notebooks are available (you can reproduce all figures!)
🔗 doi.org/10.6084/m9.f...
We hope this helps make lifetime analysis transparent and comparable across setups.
📄 www.biorxiv.org/content/10.1...

@rouxlab.bsky.social
#FLIM #FlipperTR #Microscopy #OpenScience
Data and codes
Data and codes corresponding to the preprint:
doi.org
October 5, 2025 at 4:04 PM
Reposted by Roux Lab, Geneva
juanmagararc.bsky.social
🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.

www.biorxiv.org/content/10.1...
Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM
Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...
www.biorxiv.org
October 5, 2025 at 4:04 PM
Reposted by Roux Lab, Geneva
holthuislab.bsky.social
I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂
September 30, 2025 at 6:53 PM
Reposted by Roux Lab, Geneva
mhakala.bsky.social
Undergraduate/internship/master's thesis position: jobs.helsinki.fi/job-invite/4...
Research Assistant or Master Thesis worker, group Hakala
Research Assistant or Master Thesis worker, group Hakala
jobs.helsinki.fi
September 29, 2025 at 3:45 PM
Reposted by Roux Lab, Geneva
mhakala.bsky.social
PhD student position: jobs.helsinki.fi/job-invite/4...
Doctoral Researcher, group Hakala
Doctoral Researcher, group Hakala
jobs.helsinki.fi
September 29, 2025 at 3:45 PM
Reposted by Roux Lab, Geneva
mhakala.bsky.social
I have a PhD student and an undergrad student positions open at the Institute of Biotechnology @helsinki.fi We are using reconstitution, cell and structural biology to study protein-membrane interactions and membrane microdomain formation. Links to calls below! Feel free to drop a message and share!
September 29, 2025 at 3:45 PM
Reposted by Roux Lab, Geneva
pdc-lab.bsky.social
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
journals.plos.org
September 29, 2025 at 1:47 PM
Reposted by Roux Lab, Geneva
mbisg.bsky.social
Order matters! Aurelien Roux @rouxlab.bsky.social studied the formation of multi-cellular tornado-like structures and regeneration of heads in hydra to share with us how stress fields, topology and geometry of initial tissue organization set the sequence of morphogenesis. #MBIMPG2025
September 11, 2025 at 4:38 AM
Reposted by Roux Lab, Geneva
sciezgin.bsky.social
Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
September 8, 2025 at 8:02 AM
rouxlab.bsky.social
Nice discussions after the talk given online yesterday at cytophys.org, presenting the work of @pauguillamat.bsky.social @clairedessalles.bsky.social @yamini-ravichan.bsky.social @oriolmb.bsky.social and Tithi Mandal. Available on the lab youtube channel at:
youtu.be/g-7HomnPdtk
Cell forces, order and flows during In vitro reconstitution of morphogenesis
YouTube video by Roux Lab - University of Geneva
youtu.be
July 10, 2025 at 2:20 PM
Reposted by Roux Lab, Geneva
manuelthery.bsky.social
Ever wished to become an actin star? 😎
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...
A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications
The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...
www.nature.com
July 8, 2025 at 12:46 PM
Reposted by Roux Lab, Geneva
kaksonen.bsky.social
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...
July 7, 2025 at 2:05 PM
Reposted by Roux Lab, Geneva
cellarchlab.com
The @embo.org ESCRT meeting was packed with membrane remodeling from every branch of the tree of life🌳. Some awesome science 🧪 highlights in the next posts 🧵. But a first impression… the venue!! Wow, Caux castle up a cogwheel train, overlooking Lac Léman! Perfect! 🌄 Thank you @rouxlab.bsky.social 🤗
June 27, 2025 at 2:54 PM
Reposted by Roux Lab, Geneva
juanmartin-serrano.bsky.social
What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event
June 27, 2025 at 12:59 PM
Reposted by Roux Lab, Geneva
angieprrt.bsky.social
🤩 Last week I successfully defended my PhD!
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.

@soldatilab.bsky.social
June 17, 2025 at 1:59 PM
Reposted by Roux Lab, Geneva
yamini-ravichan.bsky.social
Thank you for this opportunity @the-node.bsky.social to let me share the behind the story of my postdoc article from the @rouxlab.bsky.social here’s to squishing jellies!!
Squishing jellies!! - the Node
Behind the paper: “Topology changes of Hydra define actin orientation defects as organizers of morphogenesis”
thenode.biologists.com
June 4, 2025 at 7:50 PM
Reposted by Roux Lab, Geneva
thomaslecuit.bsky.social
This was a truly exciting talk from Aurelien Roux @rouxlab.bsky.social from Univ. Geneva 👏👏. From his landmark work on membranes to tissues now, the continuing theme is the role of geometry, topology and curvature in morphogenesis. Thanks for visiting us 🤩
centuri-ls.bsky.social CENTURI - Turing Centre for Living Systems @centuri-ls.bsky.social · Jun 2
Aurélien Roux, from Université de Genève, is now holding his CENTURI Seminar on "Topological defects in the orientational order of cells are stress organizers of tissue morphogenesis", hosted by @thomaslecuit.bsky.social
June 2, 2025 at 2:30 PM
Reposted by Roux Lab, Geneva
nordenlab.bsky.social
The amazing tour de force of the great @lcferme.bsky.social is now out in its final form in @ScienceAdvances (not on Bluesky???). It was hard work and all the conceptual advance was her doing. Check it out: www.science.org/doi/epdf/10....
Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis
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www.science.org
May 10, 2025 at 8:40 AM
Reposted by Roux Lab, Geneva
sfb1348.bsky.social
Just one week to go ⏳ until the "Cellular Interfaces Across Scales: From Molecules to Tissue Dynamics" meeting @sfb1348.bsky.social @uni-muenster.de
We can't wait to see you there!
crc1348-conference.ycode.site
#DynamicCellularInterfaces #Münster
April 29, 2025 at 3:25 PM
Reposted by Roux Lab, Geneva
sophiemartinlab.bsky.social
The lab is on a roll. 2nd preprint in as many weeks!

High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.

Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social

www.biorxiv.org/content/10.1...

@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse
Cdc42 is a Rho-family GTPase conserved across eukaryotes, where it plays essential roles in cell polarization. In single-celled yeast systems, Cdc42 is a key driver of symmetry breaking and polarized ...
www.biorxiv.org
May 6, 2025 at 11:20 AM
Reposted by Roux Lab, Geneva
sophiemartinlab.bsky.social
New lab preprint! High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction.

A very cool work led by @valthomas.bsky.social and nice collaboration with Andrea Picco and @kaksonen.bsky.social!

www.biorxiv.org/content/10.1...
Schematics of the actin fusion focus
May 2, 2025 at 8:55 AM