Rubén González
@rubengonzalez.bsky.social
Viral Infections and Virus Evolution.
A happy postdoctoral researcher at @salehlabparis.bsky.social, Institut Pasteur (Paris, France).
https://gonzalezrvirus.com
A happy postdoctoral researcher at @salehlabparis.bsky.social, Institut Pasteur (Paris, France).
https://gonzalezrvirus.com
Pinned
Rubén González
@rubengonzalez.bsky.social
· Nov 16
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rubén González
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
www.nature.com
February 3, 2026 at 11:44 AM
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...
Reposted by Rubén González
🔬 Discover the latest advances from Labex IBEID
We have released a new white paper highlighting recent scientific and technological advances from the partners.
➡️ Key results
➡️ Latest innovations
➡️ Future challenges for Emerging Infectious Diseases research
www.labexibeid.fr/en/ibeid-whi...
We have released a new white paper highlighting recent scientific and technological advances from the partners.
➡️ Key results
➡️ Latest innovations
➡️ Future challenges for Emerging Infectious Diseases research
www.labexibeid.fr/en/ibeid-whi...
February 2, 2026 at 12:30 PM
🔬 Discover the latest advances from Labex IBEID
We have released a new white paper highlighting recent scientific and technological advances from the partners.
➡️ Key results
➡️ Latest innovations
➡️ Future challenges for Emerging Infectious Diseases research
www.labexibeid.fr/en/ibeid-whi...
We have released a new white paper highlighting recent scientific and technological advances from the partners.
➡️ Key results
➡️ Latest innovations
➡️ Future challenges for Emerging Infectious Diseases research
www.labexibeid.fr/en/ibeid-whi...
Not all bacteria are beneficial in every context.
We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage.
rdcu.be/eZ4Sd
We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage.
rdcu.be/eZ4Sd
Microbiome composition modulates the lethal outcome of Drosophila A virus infection
rdcu.be
January 21, 2026 at 1:22 PM
Not all bacteria are beneficial in every context.
We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage.
rdcu.be/eZ4Sd
We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage.
rdcu.be/eZ4Sd
Reposted by Rubén González
We just uploaded our most recent paper to @biorxivpreprint.bsky.social and submitted the manuscript for publication. We are really excited with this collaboration between our lab (ColladoLab) @cimususc.bsky.social and the lab of @hanli-pasteur.bsky.social @pasteur.fr
SENOMORPHIC EFFECT OF GENETIC AND CHEMICAL PARTIAL REPROGRAMMING https://www.biorxiv.org/content/10.64898/2026.01.13.699211v1
January 14, 2026 at 10:26 AM
We just uploaded our most recent paper to @biorxivpreprint.bsky.social and submitted the manuscript for publication. We are really excited with this collaboration between our lab (ColladoLab) @cimususc.bsky.social and the lab of @hanli-pasteur.bsky.social @pasteur.fr
Reposted by Rubén González
Kicking off 2026 the best way we know how: together! 🥐👑
Our annual Galette des Rois brought the team together, and Mori Yoshida claimed the crown for the 4th year running! 🎉
But the real treasure? These moments that unite us before another year of discovery.
Here's to an incredible 2026! 🔬✨
Our annual Galette des Rois brought the team together, and Mori Yoshida claimed the crown for the 4th year running! 🎉
But the real treasure? These moments that unite us before another year of discovery.
Here's to an incredible 2026! 🔬✨
January 8, 2026 at 3:16 PM
Kicking off 2026 the best way we know how: together! 🥐👑
Our annual Galette des Rois brought the team together, and Mori Yoshida claimed the crown for the 4th year running! 🎉
But the real treasure? These moments that unite us before another year of discovery.
Here's to an incredible 2026! 🔬✨
Our annual Galette des Rois brought the team together, and Mori Yoshida claimed the crown for the 4th year running! 🎉
But the real treasure? These moments that unite us before another year of discovery.
Here's to an incredible 2026! 🔬✨
Reposted by Rubén González
If you want to help, you can share our story, check out our work at viralemergence.org, and - if you're the one in a million person who can save our project - reach out. (At this point, my job is to fundraise for the amazing scientists I work with, so they can focus on doing some actual science! 🦠)
Verena
Verena is an NSF-funded Institute working towards using open data, biological research, and artificial intelligence to predict and prevent the next pandemic.
viralemergence.org
December 5, 2025 at 3:11 PM
If you want to help, you can share our story, check out our work at viralemergence.org, and - if you're the one in a million person who can save our project - reach out. (At this point, my job is to fundraise for the amazing scientists I work with, so they can focus on doing some actual science! 🦠)
Reposted by Rubén González
Now published as version of record at @elife.bsky.social !
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
November 28, 2025 at 9:34 PM
Now published as version of record at @elife.bsky.social !
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)
elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...
#Drosophila #IDsky #SymbioSky #Infection #Immunology
Reposted by Rubén González
All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: https://ow.ly/uNqU50Xyj4e
November 26, 2025 at 7:01 PM
All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: https://ow.ly/uNqU50Xyj4e
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2025 at 12:44 AM
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rubén González
In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals.
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr
November 14, 2025 at 6:32 AM
In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals.
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr
Reposted by Rubén González
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
November 12, 2025 at 4:49 AM
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
Reposted by Rubén González
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Rubén González
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
www.nature.com
November 6, 2025 at 12:52 PM
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Reposted by Rubén González
Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 10:37 PM
Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…
Reposted by Rubén González
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
tinyurl.com
October 29, 2025 at 12:31 PM
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Reposted by Rubén González
Last chance to download my book for free! It's still available until tomorrow.
New Element in the Philosophy of Biology series—free to download until Oct. 24! @djnicholson.bsky.social uncovers Schrödinger’s motivations for writing "What Is Life?", revisits its central arguments & examines the book’s lasting impact on cell & molecular biology👇 www.cambridge.org/core/element...
October 23, 2025 at 3:40 PM
Last chance to download my book for free! It's still available until tomorrow.
Reposted by Rubén González
What makes PhD students happy? Good supervision www.nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
www.nature.com
October 23, 2025 at 9:33 AM
What makes PhD students happy? Good supervision www.nature.com/articles/d41...
Science is so much fun!
(3/5)
But first, I wanna share some sneak peeks of how this work has come to be, how I made the lab home, and the bonding that comes with working closely:
But first, I wanna share some sneak peeks of how this work has come to be, how I made the lab home, and the bonding that comes with working closely:
October 17, 2025 at 2:23 PM
Science is so much fun!
Reposted by Rubén González
I'm so excited to share this with all of you!
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
October 17, 2025 at 2:07 PM
I'm so excited to share this with all of you!
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
Reposted by Rubén González
Microbiome composition modulates the lethal outcome of Drosophila A virus infection https://www.biorxiv.org/content/10.1101/2025.10.16.682821v1
October 16, 2025 at 8:17 PM
Microbiome composition modulates the lethal outcome of Drosophila A virus infection https://www.biorxiv.org/content/10.1101/2025.10.16.682821v1
Reposted by Rubén González
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
October 15, 2025 at 4:02 PM
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
1/3 What happens when a fly gets persistently infected by a virus? In our latest work, we established persistent infections to examine their impact on this model organism. By tracking four natural, persistent RNA viruses...
October 13, 2025 at 3:25 PM
1/3 What happens when a fly gets persistently infected by a virus? In our latest work, we established persistent infections to examine their impact on this model organism. By tracking four natural, persistent RNA viruses...
Reposted by Rubén González
Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
September 26, 2025 at 3:43 PM
Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
Reposted by Rubén González
Reposted by Rubén González
Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...
September 8, 2025 at 12:58 PM
Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...