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@sandraduharcourt.bsky.social

1.3K followers 290 following 21 posts

Paramecium genome(s) aficionado; small RNAs, transposable elements, chromatin biology PI at Institut Jacques Monod, Paris, France

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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Nov 25

For my first post here, I am happy to share that our latest paper is out at #NAR. Thanks for the smooth and constructive reviewing process and the highlight #RNAbiology #TEsky #smallRNAs (1/8)
doi.org/10.1093/nar/...

The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium

Abstract. Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the

doi.org

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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · 17d

Huge congratulations to Thomas on this well-deserved award. His PhD defense last week was outstanding too - a great moment. He’ll on the lookout for a postdoc position soon…spread the word!

Institut Jacques Monod @ijmonod.bsky.social · 18d

📣 Congratulations to @thomasbalan.bsky.social (@sandraduharcourt.bsky.social Lab) who won the Best Poster Award at the Gordon Research Epigenetics conference “Variation: Mechanisms and Impact across Systems”!

More informations 🔗 buff.ly/NhLWE6G

@cnrs-idf-villejuif.bsky.social @upcite.bsky.social

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Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 8

Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September

EvoChromo: Evolutionary approaches to research in chromatin

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

meetings.embo.org

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Institut Jacques Monod @ijmonod.bsky.social · Aug 25

📢 Institut Jacques Monod Seminar

📅 September 18th
📍 Institut Jacques Monod

Invited by @sandraduharcourt.bsky.social’s lab, Peter Andersen ( @germline.bsky.social ) will give the IJM Seminar "Running to stand still – Recurrent innovation of animal germline genome regulation"

➡️ buff.ly/yaK2kTQ

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Emilie Brasset @emiliebrasset.bsky.social · Jul 2

A little late to share, but still thrilled 🤗!
What started as two independent stories, one in Clermont-Ferrand (@igred.fr) and one in Cambridge (Hannon’s group @cruk-mi.bsky.social ), turned into a joint adventure to decode how Rhino picks its favorite piRNA clusters.
When forces unite…
👇👇👇

Nature Structural & Molecular Biology @natsmb.nature.com · Jun 17

New online: Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks

Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks

Nature Structural & Molecular Biology, Published online: 17 June 2025; doi:10.1038/s41594-025-01584-8The authors reveal that, in fruit fly ovaries, the protein Rhino is guided to specific regions of the genome by a combination of two histone modifications, enhancing understanding of how cells protect their DNA from harmful virus-like elements.

go.nature.com

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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Apr 30

Bravo Thomas!

Thomas Balan @thomasbalan.bsky.social · Apr 30

I add an amazing time last week at the Epigenetics 2025 meeting from the @gensocuk.bsky.social in sunny Belfast! Great discussions and insights on my PhD project! Also very honored to have been awarded the best poster prize!

Reposted

Konrad Chudzik @konrad-chudzik.bsky.social · Apr 14

🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...

Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics

Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...

doi.org

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Nelson Lau Lab @nelson-lau-lab.bsky.social · Apr 11

Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...

Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility

Rivera et al. discover Drosophila Flamenco piRNA cluster enhancers bound and activated by the Traffic Jam transcription factor. Traffic Jam also binds many follicle cell genes including activating mul...

www.cell.com

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Institut Jacques Monod @ijmonod.bsky.social · Apr 9

🔬 This event is organized by @sandraduharcourt.bsky.social , @daphne-cabianca.bsky.social , Germano Cecere , Pierre-Antoine Defossez, Ines Drinnenberg, @rodvilla.bsky.social

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Institut Jacques Monod @ijmonod.bsky.social · Apr 9

📣 The @ijmonod.bsky.social is hosting this year the Paris-Munich Epigenetics - Workshop and Symposium, an exciting exchange between the Paris and Munich epigenetic research communities!

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Rita Rebollo @ritarebollo.bsky.social · Mar 27

Hi! Here is a PhD opportunity at Montpellier, IGH institute with Séverine Chambeyron to study endogenous retroviruses ! #TEsky #PhD

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eric lai @lucksmith.bsky.social · Mar 27

wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰

www.science.org/doi/10.1126/...

www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti...

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric tran...

www.science.org

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Journal of Cell Science @jcellsci.bsky.social · Feb 26

In her Essay, Renata Basto highlights the huge budget cuts facing the scientific community in France. In response to the cuts, a group of researchers has formed the ‘Pour une Recherche d'Avenir’ initiative to secure the future of French research.
journals.biologists.com/jcs/article/...

The importance of delivering Recherche d'Avenir – research for the future

In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...

journals.biologists.com

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Reposted

Angélique Déléris @arabette.bsky.social · Jan 22

Our paper on Alternative epigenetic states of Arabidopsis Transposable Elements is finally out in Genome Biology !

rdcu.be/d6Yly

Alternative silencing states of transposable elements in Arabidopsis associated with H3K27me3

rdcu.be

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Daniel Croll @danielcroll.bsky.social · Jan 16

@tbadet.bsky.social and I have a preprint out on transposon silencing in fungi!

Genome size evolution is fascinating and showcases the dynamic nature of transposon activation.

What we understand less are the dynamics of transposon defense systems encoded by the genomes.

doi.org/10.1101/2025...

Fungal phylogeny highlighting genome size changes

Summary of genome size variation among groups

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PLOS Biology @plosbiology.org · Jan 16

Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi

Loss of D1 during embryogenesis triggers transposon expression in adult ovaries. Top: Ovaries from the indicated genotypes (D1 and aubergine mutants and heterozygotes, F1 and F2) were stained with Vasa (green) and DAPI (magenta). Bottom: RNA in situ hybridization against Copia (green) and total polyadenylated mRNA (blue) was performed in ovaries of the indicated genotypes that were also stained for DAPI (magenta). Yellow and black arrowheads indicate undifferentiated germ cells in the aubergine mutant germarium.

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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Jan 14

Eve Charmant, Olivia's sister

sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Jan 13

Our #Paramecium artwork is featured on the cover of #NAR! doi.org/10.1093/nar/...

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Nicolas Minc @minclab.bsky.social · Jan 3

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social

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René Ketting @reneketting.bsky.social · Dec 18

www.academics.com/jobs/univers...

Please help us find a new colleague at Mainz University. Thanks!
#evolbiol

University Professor of Life History Evolution W3 - Johannes Gutenberg-Universität Mainz

Johannes Gutenberg-Universität Mainz looks for University Professor of Life History Evolution W3 in Mainz - apply now!

www.academics.com

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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Dec 18

Thank you @cnrs.bsky.social for the highlight (in French) on our recent publication.

Olivia Charmant @oliviacharmant.bsky.social · Dec 18

A brief overview of my latest project in the Duharcourt lab, highlighted by @cnrs.bsky.social and a sneak peek in the head of an artist (aka my sister) inspired by Paramecium.

Tri sélectif des petits ARN : un enjeu pour préserver l’intégrité du génome

Dans un article publié dans Nucleic Acids Research, des scientifiques ont identifié un nouveau rôle pour la protéine

www.insb.cnrs.fr

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Maxim Greenberg @maxvcg.bsky.social · Dec 12

I hope everyone who starts their lab has a Julien @jrichardalbert.bsky.social . 8 publications, 3 as first author and a review. Plus a brilliant scientist, an eager teacher, and just plain nice. He was the bedrock of our lab, but a bright future awaits!

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sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Dec 3

Congrats Arnau!

sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Dec 3

Congratulations Antoine !

sandraduharcourt.bsky.social @sandraduharcourt.bsky.social · Dec 2

The 2nd edition of the Paris-Munich Epigenetics meeting will be held April 9-11, 2025 in Paris. Attendance is free of charge.

Please visit the website
www.sfb1064.med.uni-muenchen.de/paris_munich...
to find out more about the program and to register. #epigenetics

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JKNowak Lab @jknowaklab.bsky.social · Nov 29

doi.org/10.1093/nar/...
In order to introduce myself here, I would like to share our recent paper published as Breakthrough Article at #NAR. Great collaboration with Duharcourt @sandraduharcourt.bsky.social team and the financial support from #NCN @ncngovpl.bsky.social.
#smallRNAs #Paramecium

The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium

Abstract. Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the

doi.org

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