Sarah Lempriere
@sarahlempriere.bsky.social
Senior Editor at Science. I handle Perspective articles in neuroscience, genetics, biochemistry and plant science. Views are my own.
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace? | Science | AAAS www.science.org/content/arti...
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?
Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology
www.science.org
November 21, 2025 at 3:35 PM
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace? | Science | AAAS www.science.org/content/arti...
Reposted by Sarah Lempriere
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
Reposted by Sarah Lempriere
Check out my Perspective article “The Retina’s Rhythm” which accompanies an exciting paper by Claude Desplan in Science. I highlight his discovery that waves of calcium are required to finalize the honeycomb-like structure of the Drosophila retina.
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
The retina’s rhythm
Calcium waves facilitate the emergence of sight
www.science.org
November 21, 2025 at 2:00 PM
Check out my Perspective article “The Retina’s Rhythm” which accompanies an exciting paper by Claude Desplan in Science. I highlight his discovery that waves of calcium are required to finalize the honeycomb-like structure of the Drosophila retina.
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Sarah Lempriere
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 21, 2025 at 10:20 AM
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
Reposted by Sarah Lempriere
Using an integrative phylogenomic approach, new research in Science reveals unprecedented phylogenomic support for sponges as the sister lineage to all other animals.
Learn more in a new #SciencePerspective: https://scim.ag/4r7SLqm
Learn more in a new #SciencePerspective: https://scim.ag/4r7SLqm
Sponging away phylogenomic incongruence
Genes with strong and consistent signals favor sponges as humans’ most distant animal relatives
scim.ag
November 19, 2025 at 8:54 PM
Using an integrative phylogenomic approach, new research in Science reveals unprecedented phylogenomic support for sponges as the sister lineage to all other animals.
Learn more in a new #SciencePerspective: https://scim.ag/4r7SLqm
Learn more in a new #SciencePerspective: https://scim.ag/4r7SLqm
Reposted by Sarah Lempriere
also, an excellent perspective by @dbikard.bsky.social summarizing the work! 🙏
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Programmable DNA insertion in native gut bacteria
A gene-editing approach enables modification of bacteria within the mouse gut
www.science.org
November 13, 2025 at 9:39 PM
also, an excellent perspective by @dbikard.bsky.social summarizing the work! 🙏
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sarah Lempriere
I just finished my 2nd reading of this perspective. It is so great. The article captures a great deal about the sponge/ctenophore and is measured in its assessment of what the true tree is.
I absolutely share this position
bsky.app/profile/jlst...
I absolutely share this position
bsky.app/profile/jlst...
And a great perspective by Peter and Anthony!
www.science.org/doi/10.1126/...
bsky.app/profile/jlst...
www.science.org/doi/10.1126/...
bsky.app/profile/jlst...
November 14, 2025 at 4:36 AM
I just finished my 2nd reading of this perspective. It is so great. The article captures a great deal about the sponge/ctenophore and is measured in its assessment of what the true tree is.
I absolutely share this position
bsky.app/profile/jlst...
I absolutely share this position
bsky.app/profile/jlst...
Reposted by Sarah Lempriere
The neural circuits and signalling pathways of opioid use disorder — a Review by Victor P. Mathis, Aliza T. Ehrlich & Emmanuel Darcq
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
The neural circuits and signalling pathways of opioid use disorder - Nature Reviews Neuroscience
In many parts of the world, opioid use disorder presents a growing challenge to public health, reinforcing the need to decipher its underlying mechanisms. Mathis et al. provide an overview of our curr...
www.nature.com
November 6, 2025 at 4:26 PM
The neural circuits and signalling pathways of opioid use disorder — a Review by Victor P. Mathis, Aliza T. Ehrlich & Emmanuel Darcq
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Reposted by Sarah Lempriere
This week on the @science.org podcast: A 3-decade partnership between archaeologists and the Kuikuro people offers a model of collaboration—and documents the complexity of early Amazonian societies.
LISTEN HERE 🎧 www.science.org/content/podc...
LISTEN HERE 🎧 www.science.org/content/podc...
November 6, 2025 at 9:05 PM
This week on the @science.org podcast: A 3-decade partnership between archaeologists and the Kuikuro people offers a model of collaboration—and documents the complexity of early Amazonian societies.
LISTEN HERE 🎧 www.science.org/content/podc...
LISTEN HERE 🎧 www.science.org/content/podc...
Reposted by Sarah Lempriere
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more this week: https://scim.ag/4nFEGO7
Learn more this week: https://scim.ag/4nFEGO7
November 6, 2025 at 7:05 PM
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more this week: https://scim.ag/4nFEGO7
Learn more this week: https://scim.ag/4nFEGO7
Reposted by Sarah Lempriere
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
How mRNA Vaccines Can Help Fight Cancer
Turning "cold" tumors "hot"
erictopol.substack.com
October 22, 2025 at 3:19 PM
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
Some beautiful images in this Perspective piece, and the science is fascinating too! www.science.org/doi/10.1126/...
How common cuckoos adapt to multiple hosts
Genomic data reveal the complexity of egg mimicry evolution in cuckoos
www.science.org
October 30, 2025 at 8:40 PM
Some beautiful images in this Perspective piece, and the science is fascinating too! www.science.org/doi/10.1126/...
Reposted by Sarah Lempriere
Also check out the great summary perspectives in @science.org by Lindsay Zanno featuring @nataliajagielska.bsky.social’s incredible illustration of the end-Cretaceous asteroid impact: www.science.org/doi/10.1126/...
October 24, 2025 at 12:39 AM
Also check out the great summary perspectives in @science.org by Lindsay Zanno featuring @nataliajagielska.bsky.social’s incredible illustration of the end-Cretaceous asteroid impact: www.science.org/doi/10.1126/...
Reposted by Sarah Lempriere
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
Cell-type- and locus-specific epigenetic editing of memory expression - Nature Genetics
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
www.nature.com
October 29, 2025 at 11:11 AM
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
There is a form of mosquito that lives in subways and tube tunnels across the world - did it evolve recently to take advantage of this urban environment or has it been around for much longer? www.science.org/doi/10.1126/...
Urban pests traveled with ancient humans
Population genomics reveals the pre-urban origins of a common mosquito
www.science.org
October 23, 2025 at 6:37 PM
There is a form of mosquito that lives in subways and tube tunnels across the world - did it evolve recently to take advantage of this urban environment or has it been around for much longer? www.science.org/doi/10.1126/...
Parasitic plants attach to host plants to siphon off water and nutrients, but how do they avoid parasitizing their own kind? www.science.org/doi/10.1126/...
The paradox of kin avoidance in parasitic plants
Parasitic plants use glucosylation to avoid kin parasitism
www.science.org
October 23, 2025 at 6:29 PM
Parasitic plants attach to host plants to siphon off water and nutrients, but how do they avoid parasitizing their own kind? www.science.org/doi/10.1126/...
Reposted by Sarah Lempriere
Naturalistic approaches such as Ulanovsky’s open up “potential opportunities to really reveal why the brain is structured in the way it’s structured,” says Iain Couzin.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/neuroetholog...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/neuroetholog...
Diving in with Nachum Ulanovsky
With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.
www.thetransmitter.org
October 20, 2025 at 7:03 PM
Naturalistic approaches such as Ulanovsky’s open up “potential opportunities to really reveal why the brain is structured in the way it’s structured,” says Iain Couzin.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/neuroetholog...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/neuroetholog...
Reposted by Sarah Lempriere
Kiss, Shrink, Run ⛹🏻♀️ New Perspective in @science.org about one of my favourite topics: how synapses and their tiny vesicles communicate in the brain. Chang-Lu Tao and colleagues reveal a previously unknown pathway for vesicle release. Read more here: doi.org/10.1126/scie... @istaresearch.bsky.social
Kiss, shrink, run
A unified mechanism directs synaptic vesicle release
doi.org
October 19, 2025 at 1:46 PM
Kiss, Shrink, Run ⛹🏻♀️ New Perspective in @science.org about one of my favourite topics: how synapses and their tiny vesicles communicate in the brain. Chang-Lu Tao and colleagues reveal a previously unknown pathway for vesicle release. Read more here: doi.org/10.1126/scie... @istaresearch.bsky.social
Reposted by Sarah Lempriere
📢 June 8th-9th 2026 Bristol University 📢
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
UK Glia 2026
UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...
www.physoc.org
October 20, 2025 at 12:54 PM
📢 June 8th-9th 2026 Bristol University 📢
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.
Check out the exciting programme here:
www.physoc.org/events/uk-gl...
#neuroskyence #glia
Kiss, shrink, run | Science www.science.org/doi/10.1126/...
Kiss, shrink, run
A unified mechanism directs synaptic vesicle release
www.science.org
October 18, 2025 at 3:23 PM
Kiss, shrink, run | Science www.science.org/doi/10.1126/...
Neural compass in the sky | Science www.science.org/doi/10.1126/...
Neural compass in the sky
Head-direction neurons maintain stable directional signals during large-scale navigation in the wild
www.science.org
October 18, 2025 at 3:22 PM
Neural compass in the sky | Science www.science.org/doi/10.1126/...
Reposted by Sarah Lempriere
Neuroscience projects last several years, and you are usually a bit jaded by the time you wrap it up. Not this one– spending several months on an island in the middle of nowhere, away from all the craziness of the world reminds you how beautiful the world really is.
www.youtube.com/watch?v=46sv...
www.youtube.com/watch?v=46sv...
Bat Island: The New Era of Science
YouTube video by Weizmann Institute of Science
www.youtube.com
October 17, 2025 at 7:07 AM
Neuroscience projects last several years, and you are usually a bit jaded by the time you wrap it up. Not this one– spending several months on an island in the middle of nowhere, away from all the craziness of the world reminds you how beautiful the world really is.
www.youtube.com/watch?v=46sv...
www.youtube.com/watch?v=46sv...
Reposted by Sarah Lempriere
Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment.
Learn more in a new #SciencePerspective: https://scim.ag/4qaRWNh
Learn more in a new #SciencePerspective: https://scim.ag/4qaRWNh
Natural directed evolution in gut microbiota
Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment
scim.ag
October 17, 2025 at 7:15 PM
Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment.
Learn more in a new #SciencePerspective: https://scim.ag/4qaRWNh
Learn more in a new #SciencePerspective: https://scim.ag/4qaRWNh
Reposted by Sarah Lempriere
Wonderful to see this beautiful image on the cover of Science this week highlighting a paper that uses high resolution imaging to show the spatial patterns of bacterial attraction to glutamine from roots.
Paper here: www.science.org/doi/10.1126/...
Perspective here: www.science.org/doi/10.1126/...
Paper here: www.science.org/doi/10.1126/...
Perspective here: www.science.org/doi/10.1126/...
October 7, 2025 at 9:52 AM
Wonderful to see this beautiful image on the cover of Science this week highlighting a paper that uses high resolution imaging to show the spatial patterns of bacterial attraction to glutamine from roots.
Paper here: www.science.org/doi/10.1126/...
Perspective here: www.science.org/doi/10.1126/...
Paper here: www.science.org/doi/10.1126/...
Perspective here: www.science.org/doi/10.1126/...