Shabaz Lab
@shabazlab.bsky.social
Reposted by Shabaz Lab
Our latest #proteomics product to top off our Lys-C and Trypsin offerings. A high quality optimal premix of Lys-C and Trypsin that enables reproducible proteomic analysis! Make sure to follow @kplaps.bsky.social for more exciting news and updates!
#TeamMassSpec
#TeamMassSpec
🧪 Just launched: Trypsin/Lys-C Premium Mix 🚀
We found that with the right formulation, you can add Lys-C and Trypsin together instead of sequentially. So we made it 💡
✅ One step
✅ Lowest missed cleavages in its class
✅ Fully recombinant
🪧Available now
🔗 kplbio.com/trypsinlysc/
We found that with the right formulation, you can add Lys-C and Trypsin together instead of sequentially. So we made it 💡
✅ One step
✅ Lowest missed cleavages in its class
✅ Fully recombinant
🪧Available now
🔗 kplbio.com/trypsinlysc/
February 17, 2026 at 2:07 PM
Our latest #proteomics product to top off our Lys-C and Trypsin offerings. A high quality optimal premix of Lys-C and Trypsin that enables reproducible proteomic analysis! Make sure to follow @kplaps.bsky.social for more exciting news and updates!
#TeamMassSpec
#TeamMassSpec
Reposted by Shabaz Lab
Poly-ubiquitylated proteins proved trickier to purify for LC-MS than expected. Non-specific background swamped isolations: with histones and uncertainty!
This led us to develop Ubi-SCAPE—for characterising the poly-ubiquitylome to unprecedented purity and depth.
www.biorxiv.org/content/10.6...
This led us to develop Ubi-SCAPE—for characterising the poly-ubiquitylome to unprecedented purity and depth.
www.biorxiv.org/content/10.6...
February 16, 2026 at 3:57 PM
Poly-ubiquitylated proteins proved trickier to purify for LC-MS than expected. Non-specific background swamped isolations: with histones and uncertainty!
This led us to develop Ubi-SCAPE—for characterising the poly-ubiquitylome to unprecedented purity and depth.
www.biorxiv.org/content/10.6...
This led us to develop Ubi-SCAPE—for characterising the poly-ubiquitylome to unprecedented purity and depth.
www.biorxiv.org/content/10.6...
Just saw an advert for family backed mortgages. Well, that's one way for house prices to continue increasing. I guess that's the goal.
February 15, 2026 at 6:32 PM
Just saw an advert for family backed mortgages. Well, that's one way for house prices to continue increasing. I guess that's the goal.
close enough?! (home made needle columns)
February 10, 2026 at 4:28 PM
close enough?! (home made needle columns)
Reposted by Shabaz Lab
Who influences policy linked to your research – and who’s affected by it?
Join this interactive workshop for researchers and DPhil students on stakeholder mapping, policy audiences, and engagement strategies.
📅 Tuesday 17 February 2026
➡️ Find out more: https://tinyurl.com/mw4akvhz
Join this interactive workshop for researchers and DPhil students on stakeholder mapping, policy audiences, and engagement strategies.
📅 Tuesday 17 February 2026
➡️ Find out more: https://tinyurl.com/mw4akvhz
February 9, 2026 at 11:04 AM
Who influences policy linked to your research – and who’s affected by it?
Join this interactive workshop for researchers and DPhil students on stakeholder mapping, policy audiences, and engagement strategies.
📅 Tuesday 17 February 2026
➡️ Find out more: https://tinyurl.com/mw4akvhz
Join this interactive workshop for researchers and DPhil students on stakeholder mapping, policy audiences, and engagement strategies.
📅 Tuesday 17 February 2026
➡️ Find out more: https://tinyurl.com/mw4akvhz
Reposted by Shabaz Lab
Yesterday we came together to honour Professor Raymond Dwek through the naming of the Raymond Dwek Seminar Room. Raymond's family (pictured) joined the celebration and Raymond was visibly touched, saying: "Thank you for this amazing gesture. I'm humbled by it, but I will treasure it."
February 6, 2026 at 2:29 PM
Yesterday we came together to honour Professor Raymond Dwek through the naming of the Raymond Dwek Seminar Room. Raymond's family (pictured) joined the celebration and Raymond was visibly touched, saying: "Thank you for this amazing gesture. I'm humbled by it, but I will treasure it."
I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course.
www.brixenproteomics.org
www.brixenproteomics.org
In 2026 the established Brixen Proteomics Summer School
FEBS Advanced Lecture Course
www.brixenproteomics.org
February 6, 2026 at 10:04 AM
I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course.
www.brixenproteomics.org
www.brixenproteomics.org
Reposted by Shabaz Lab
Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. www.nature.com/articles/s41...
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator - Nature Communications
Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insul...
www.nature.com
February 5, 2026 at 6:32 PM
Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. www.nature.com/articles/s41...
Reposted by Shabaz Lab
Really happy to see this work out!
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology
Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...
doi.org
February 5, 2026 at 7:12 PM
Really happy to see this work out!
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
Reposted by Shabaz Lab
#TeamMassSpec Question for XL-MS practitioners.. Looking for a suitable crosslinker to stabilise a protein complex in vitro.. What are the pros and cons for MS-cleavable vs non-cleavable cross-linkers?? Is PhoX a good choice?? Any recommendations for MS-cleavable cross-linkers?? Thanks very much..
February 3, 2026 at 10:03 PM
#TeamMassSpec Question for XL-MS practitioners.. Looking for a suitable crosslinker to stabilise a protein complex in vitro.. What are the pros and cons for MS-cleavable vs non-cleavable cross-linkers?? Is PhoX a good choice?? Any recommendations for MS-cleavable cross-linkers?? Thanks very much..
First day of the year where solar makes enough electricity for the house for the whole day. February!
February 4, 2026 at 3:35 PM
First day of the year where solar makes enough electricity for the house for the whole day. February!
Reposted by Shabaz Lab
Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins https://www.biorxiv.org/content/10.64898/2026.01.29.701737v1
January 30, 2026 at 3:18 AM
Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins https://www.biorxiv.org/content/10.64898/2026.01.29.701737v1
I am embarrassed to say I had a small part in this fantastic study led by @marvintanenbaum.bsky.social
Nature research paper: Pre-assembly of biomolecular condensate seeds drives RSV replication
go.nature.com/3NIdNNn
go.nature.com/3NIdNNn
Pre-assembly of biomolecular condensate seeds drives RSV replication - Nature
Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
go.nature.com
February 1, 2026 at 10:37 AM
I am embarrassed to say I had a small part in this fantastic study led by @marvintanenbaum.bsky.social
Bleak. For the mas spec community, there was the additional blow that the recently funded C-Mass initiative was also cancelled. Not great times.
Startling that this is being broadcast in the absence of any public communications by @ukri.org
The academic community has a right to expect to be told first hand what is happening with response mode funding and what the immediate future looks like
www.researchprofessionalnews.com/rr-news-uk-r...
The academic community has a right to expect to be told first hand what is happening with response mode funding and what the immediate future looks like
www.researchprofessionalnews.com/rr-news-uk-r...
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
www.researchprofessionalnews.com
January 30, 2026 at 7:38 PM
Bleak. For the mas spec community, there was the additional blow that the recently funded C-Mass initiative was also cancelled. Not great times.
Reposted by Shabaz Lab
Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.
January 30, 2026 at 4:46 PM
Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.
From overturning 50 years of cell envelope dogma to weaponizing toxins, Colin Kleanthous’s career has been extraordinary. This JBC "Reflections" is a poignant final gift, taking his work to "unimagined destinations" as he says a moving farewell to the lab
tinyurl.com/4vmbwcw7
#Microbiology #SciSky
tinyurl.com/4vmbwcw7
#Microbiology #SciSky
Bacteriocin biophysics: From protein-protein interaction models to navigators of the bacterial cell envelope
Bacteriocins are toxins deployed by bacteria to kill their competitors. Here, I reflect
on my laboratory’s work on protein bacteriocins and their immunity proteins from Gram-negative
bacteria. We unco...
tinyurl.com
January 29, 2026 at 6:52 PM
From overturning 50 years of cell envelope dogma to weaponizing toxins, Colin Kleanthous’s career has been extraordinary. This JBC "Reflections" is a poignant final gift, taking his work to "unimagined destinations" as he says a moving farewell to the lab
tinyurl.com/4vmbwcw7
#Microbiology #SciSky
tinyurl.com/4vmbwcw7
#Microbiology #SciSky
Reposted by Shabaz Lab
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
rdcu.be/e1bBW
Pre-assembly of biomolecular condensate seeds drives RSV replication
Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
rdcu.be
January 28, 2026 at 8:38 PM
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
rdcu.be/e1bBW
Reposted by Shabaz Lab
The Field and Franklin Award for Mass Spectrometry is back! Since 1985, this award has recognize outstanding achievement in the development or application of #massspec #teammassspec. Please submit nominations by November 14! Nomination details: acsanalytical.org/awards-resou...
Division of Analytical Chemistry Awards
Visit the post for more.
acsanalytical.org
November 1, 2025 at 4:32 PM
The Field and Franklin Award for Mass Spectrometry is back! Since 1985, this award has recognize outstanding achievement in the development or application of #massspec #teammassspec. Please submit nominations by November 14! Nomination details: acsanalytical.org/awards-resou...
Reposted by Shabaz Lab
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology
RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...
www.nature.com
January 27, 2026 at 7:32 AM
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
Reposted by Shabaz Lab
Whether you're searching for your next role or keeping an eye on trends in the field, our Career Center's job board is a great place to see what’s new across the mass spectrometry community.
Browse current postings: https://bit.ly/4agQCTD #ASMS #MassSpec #TeamMassSpec
Browse current postings: https://bit.ly/4agQCTD #ASMS #MassSpec #TeamMassSpec
January 27, 2026 at 6:40 PM
Whether you're searching for your next role or keeping an eye on trends in the field, our Career Center's job board is a great place to see what’s new across the mass spectrometry community.
Browse current postings: https://bit.ly/4agQCTD #ASMS #MassSpec #TeamMassSpec
Browse current postings: https://bit.ly/4agQCTD #ASMS #MassSpec #TeamMassSpec
Reposted by Shabaz Lab
Reposted by Shabaz Lab
Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 20, 2026 at 12:27 PM
Excited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Back in my favourite part of the US (Denmark) and enjoying a typical and delicious breakfast
January 15, 2026 at 6:37 AM
Back in my favourite part of the US (Denmark) and enjoying a typical and delicious breakfast
Reposted by Shabaz Lab
Reposted by Shabaz Lab
Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine, Mol Cell Proteomics, 2025, 24(4), 100948, doi.org/10.1016/j.mc...
April 8, 2025 at 8:26 AM
Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine, Mol Cell Proteomics, 2025, 24(4), 100948, doi.org/10.1016/j.mc...