Ethan Goddard-Borger
@ethangbaus.bsky.social
Glycobiology | Chemical Biology | Drug Development
Prof @ Walter and Eliza Hall Institute, Melbourne, Australia
Prof @ Walter and Eliza Hall Institute, Melbourne, Australia
Reposted by Ethan Goddard-Borger
We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM
Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates - Nature Chemical Biology
Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...
doi.org
February 5, 2026 at 11:23 PM
We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM
Reposted by Ethan Goddard-Borger
WEHI researchers have helped to engineer an antibody that can clear otherwise lethal multidrug‑resistant Acinetobacter baumannii infections in mice by homing in on the bacterial sugar pseudaminic acid.
Brilliant findings, published in Nature Chemical Biology
www.wehi.edu.au/news/sugar-m...
🧵1/2
Brilliant findings, published in Nature Chemical Biology
www.wehi.edu.au/news/sugar-m...
🧵1/2
February 4, 2026 at 11:55 PM
WEHI researchers have helped to engineer an antibody that can clear otherwise lethal multidrug‑resistant Acinetobacter baumannii infections in mice by homing in on the bacterial sugar pseudaminic acid.
Brilliant findings, published in Nature Chemical Biology
www.wehi.edu.au/news/sugar-m...
🧵1/2
Brilliant findings, published in Nature Chemical Biology
www.wehi.edu.au/news/sugar-m...
🧵1/2
🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology
Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...
doi.org
February 4, 2026 at 10:32 PM
🚨 Our new paper is out today in Nature Chemical Biology:
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
“Pan-specific antibodies to uncover bacterial pseudaminylation”
doi.org/10.1038/s415...
This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself.
1/6
Reposted by Ethan Goddard-Borger
In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2
Deep contrastive learning enables genome-wide virtual screening
Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...
scim.ag
January 17, 2026 at 7:15 PM
In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2
Reposted by Ethan Goddard-Borger
GLYCO-BUILD, an entirely enzymatic approach for the production of N-glycans and N-glycopeptides.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 15, 2026 at 3:17 AM
GLYCO-BUILD, an entirely enzymatic approach for the production of N-glycans and N-glycopeptides.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ethan Goddard-Borger
A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.
A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Accurate and comprehensive peptide spectrum annotation is a crucial step to interpreting mass spectrometry-based proteomics data. While peak assignment in peptide fragmentation spectra is central to a...
pubs.acs.org
December 29, 2025 at 3:53 PM
A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.
Reposted by Ethan Goddard-Borger
🎉 Congratulations to our 2026 AGS EMCR Award winners! 🎉
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
December 18, 2025 at 9:21 PM
🎉 Congratulations to our 2026 AGS EMCR Award winners! 🎉
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
Reposted by Ethan Goddard-Borger
The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb
December 16, 2025 at 10:12 AM
The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb
Reposted by Ethan Goddard-Borger
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
go.nature.com
December 16, 2025 at 4:55 PM
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
Reposted by Ethan Goddard-Borger
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.
www.science.org
November 19, 2025 at 7:04 PM
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Reposted by Ethan Goddard-Borger
The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...
#ChemNobel #Chem #Chemistry #chemsky 🧪
#ChemNobel #Chem #Chemistry #chemsky 🧪
The 2025 chemistry Nobel goes to MOFs
Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks
cen.acs.org
October 8, 2025 at 10:12 AM
The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...
#ChemNobel #Chem #Chemistry #chemsky 🧪
#ChemNobel #Chem #Chemistry #chemsky 🧪
Reposted by Ethan Goddard-Borger
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
October 6, 2025 at 9:27 PM
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
Reposted by Ethan Goddard-Borger
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase
O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...
chemrxiv.org
October 7, 2025 at 6:10 AM
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Reposted by Ethan Goddard-Borger
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
September 28, 2025 at 9:16 PM
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
Reposted by Ethan Goddard-Borger
Reposted by Ethan Goddard-Borger
Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social
September 3, 2025 at 10:00 AM
Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social
Reposted by Ethan Goddard-Borger
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.
🔗 www.wehi.edu.au/news/eureka-...
🔗 www.wehi.edu.au/news/eureka-...
September 3, 2025 at 9:54 PM
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.
🔗 www.wehi.edu.au/news/eureka-...
🔗 www.wehi.edu.au/news/eureka-...
Reposted by Ethan Goddard-Borger
The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!
Director, Centre for Chemistry and Drug Discovery
Institute for Molecular Bioscience Join a university ranked in the world’s top 50 Australia’s #1 research institute Based at St Lucia Campus About UQ What started as Queensland's first university in 1...
uq.wd3.myworkdayjobs.com
September 2, 2025 at 2:46 AM
The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!
Reposted by Ethan Goddard-Borger
Last but most certainly not least, The President’s Innovator Award 2025 goes to
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
August 13, 2025 at 3:59 AM
Last but most certainly not least, The President’s Innovator Award 2025 goes to
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
Reposted by Ethan Goddard-Borger
#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context - Nature Chemical Biology
Structural studies of certain Tn and STn antigen-targeting antibodies reveal that their VH and VL domains recognize the glycan antigen and the adjacent peptide region, respectively, enabling a VH doma...
www.nature.com
August 1, 2025 at 7:50 PM
#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ethan Goddard-Borger
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research
YouTube video by Australian Museum
www.youtube.com
July 31, 2025 at 12:00 AM
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Reposted by Ethan Goddard-Borger
ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...
July 24, 2025 at 2:44 AM
ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...
Reposted by Ethan Goddard-Borger
Introducing Latent-X — our all-atom frontier AI model for protein binder design.
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
July 22, 2025 at 6:21 AM
Introducing Latent-X — our all-atom frontier AI model for protein binder design.
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
Reposted by Ethan Goddard-Borger
❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX
#CryoEM #apoptosis #mitochondria #BAX
June 27, 2025 at 4:33 AM
❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX
#CryoEM #apoptosis #mitochondria #BAX
Reposted by Ethan Goddard-Borger
New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
June 12, 2025 at 8:20 AM
New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3
doi.org/10.1101/2025...
doi.org/10.1101/2025...