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Stefan Schandelmaier

@sschandelmaier.bsky.social

210 followers 300 following 12 posts

Health research methodologist, methods guidance & implementation, meta-science. www.LIGHTS.science @lightsdatabase.bsky.social www.ICEMAN.help @clinepi-basel.bsky.social

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Stefan Schandelmaier @sschandelmaier.bsky.social · Feb 27

I’m thrilled that leading research groups now recommend our #ICEMANtool to evaluate possible subgroup effects:
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...

Welcome to the web pages for ICEMAN! ICEMAN is an instrument to help researchers identify credible effect modification (also called subgroup effect, statistical interaction, moderation, or heterogenei...

www.iceman.help

Reposted by David Tovey, Stefan Schandelmaier

Richard Hooper @richardhooper.bsky.social · Nov 29

J Clin EPi @jclinepi.bsky.social has a unique focus on meta-research. I've co-led a November editorial reflecting on the variety its content, and how an even richer balance might be achieved. Methodologists assemble! www.jclinepi.com/article/S089... @davidit.bsky.social @andreatricco.bsky.social

What advice can we offer to authors? Reflections from the statisticians’ bench

What are the statistical issues on which the Journal of Clinical Epidemiology editorial team should be offering advice to authors? Lists of statistical bugbears and elephant traps in health research r...

www.jclinepi.com

Reposted by Stefan Schandelmaier

Clinical Epidemiology Basel @clinepi-basel.bsky.social · May 15

With over 96% of global trial data on this topic included, this #IPDMA, published in @lancetrespirmed.bsky.social and initiated by #EU-RESPONSE, provides the most comprehensive analysis for JAK inhibitors for adults hospitalized due to #COVID19.

Full article: www.thelancet.com/journals/lan...

Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials

This IPDMA of RCTs in adults admitted to hospital due to COVID-19 found that JAK inhibitors reduced mortality across all levels of respiratory support, independent of dexamethasone or tocilizumab, and...

www.thelancet.com

Stefan Schandelmaier @sschandelmaier.bsky.social · May 2

Finally!
www.bbc.com/news/article...

AfD classified as extreme-right by German intelligence

The AfD came second in February elections and has a record number of seats in the new parliament.

Reposted by Anne van Aaken, Marina Dossena, Stefan Schandelmaier

ChrisO_wiki @chriso-wiki.bsky.social · Feb 22

Ian Fleming's original James Bond novels haven't aged well. For example, Moonraker - published almost exactly 70 years ago in April 1955 - features a villain who's a super-rich industrialist and rocket-maker seeking to cause chaos because he's a secret Nazi. Such a silly idea!

a man with a beard is sitting in a room with a harp in the background

ALT: a man with a beard is sitting in a room with a harp in the background

media.tenor.com

Reposted by Stefan Schandelmaier

Prof Nisreen Alwan @nisreenalwan.bsky.social · Feb 20

Hi @bmj.com
Can you add a Bluesky share button instead of the X button you have please?

Reposted by Scott F. Kiesling, Helen Schwenken, Yara Mekawi , and 2 more Scott F. Kiesling, Helen Schwenken, Yara Mekawi, Stefan Schandelmaier, Sue Timmis

Marc Fischer @marc-fischer.bsky.social · Feb 16

Time to evict AirBnB from your life, if you have't already.

Airbnb’s co-founder is joining Elon Musk’s DOGE

Gebbia, a close friend of Musk, has praised DOGE’s work and defended it against criticisms on social media

www.independent.co.uk

Reposted by Stefan Schandelmaier

Thomas Agoritsas @thomasagoritsas.bsky.social · Feb 4

Have you checked our risk-stratified #RapidRecs on #PCSK9 inhibitors and #ezetimibe for the reduction of cardiovascular events ?
@magicevidence.bsky.social @bmj.com
-->https://www.bmj.com/content/377/bmj-2021-069066

Reposted by Stefan Schandelmaier

Adam Kucharski @adamjkucharski.bsky.social · Feb 2

The risks of backing scattered islands of sensible points in a sea of nonsense: kucharski.substack.com/p/islands-of...

Stefan Schandelmaier @sschandelmaier.bsky.social · Jan 24

www.thelancet.com/journals/lan...

Health in the age of disinformation

Health misinformation (false or misleading data shared unintentionally) and disinformation (deliberately deceptive information) are not new, but the COVID-19 pandemic marked a turning point. The sense...

www.thelancet.com

Stefan Schandelmaier @sschandelmaier.bsky.social · Jan 11

So true!

Georgios Vleioras @gvleioras.bsky.social · Jan 11

I just saw this elsewhere and it made me think of our discussion here:

Reposted by Stefan Schandelmaier

Georgios Vleioras @gvleioras.bsky.social · Jan 11

I just saw this elsewhere and it made me think of our discussion here:

Stefan Schandelmaier @sschandelmaier.bsky.social · Jan 3

A better statistic might be the prediction interval but in my view the community needs to develop more experience with it before we can use it to confidentially judge relevance of heterogeneity (if ever). And unfortunately it does not work very well in a meta-analysis with only a few studies

Stefan Schandelmaier @sschandelmaier.bsky.social · Jan 3

True. But what else can we do? A paper in the new Core GRADE series (currently under revision in the BMJ) offers a practical solution based on visual inspection of both overlap of confidence intervals (similar to I2) but also where point estimates lie in relation to a relevance threshold.

Reposted by Stefan Schandelmaier

Peter Rowlett @peterrowlett.net · Jan 1

Happy New Year! I wrote a list of numerical coincidences involving 2025, see if you spot something fun!

#MathsSky #MathSky #MathsToday #MathChat

Numerical coincidences for 2025

There seem to be a lot of numerical coincidences bouncing around concerning the new year 2025. For example, it’s a square number: \( 2025 = 45^2 \). The last square year was \(44^2 = 1936\), …

aperiodical.com

Stefan Schandelmaier @sschandelmaier.bsky.social · Dec 30

www.ted.com/talks/jimmy_...

Why I believe the mistreatment of women is the number one human rights abuse

With his signature resolve, former US President Jimmy Carter dives into three unexpected reasons why the mistreatment of women and girls continues in so many manifestations in so many parts of the wor...

Reposted by Stefan Schandelmaier

Hilda Bastian @hildabast.bsky.social · Dec 28

Ever wonder about the basis for fear-mongering & conspiracy theories about mRNA vax? Wish you had a place to go when someone cites "proof"?

I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2

absolutelymaybe.plos.org/2024/12/28/g...

Getting Ready for More mRNA Vaccine Fear-Mongering: A Compendium - Absolutely Maybe

Recently, I wrote about a depressingly successful campaign against the introduction of a next generation Covid vaccine in Japan. It is a…

absolutelymaybe.plos.org

Reposted by Stefan Schandelmaier

George Takei @georgetakei.bsky.social · Dec 23

Vaccines stopped polio.

The image is a graph titled "Reported paralytic polio cases and deaths, United States, 1910 to 2019," from Our World in Data. It shows the annual number of polio cases (in red) and deaths (in green). A sharp decline in both cases and deaths occurs after the introduction of the polio vaccine in 1957, which is marked with an arrow labeled "Vaccine introduced in 1957." The graph illustrates the dramatic impact of vaccination on reducing polio cases and fatalities over time.

Reposted by Stefan Schandelmaier

Johannes Schwenke @schwenkej.bsky.social · Dec 23

1/ Excited to share thoughts on two excellent blog posts about clinical trials! First up: "The Case for Clinical Trial Abundance" by @ruxandrabio.bsky.social and Willy Chertman . They argue we need more clinical trials & that bureaucracy hampers faster progress. A sentiment I fully share!

The case for clinical trial abundance

A supply-side reform agenda for one of our most urgent problems

www.slowboring.com

Stefan Schandelmaier @sschandelmaier.bsky.social · Dec 22

Methods guidance is evolving. Here the authors chose to provide explicit recommendations both in favor but also agains certain methods. I think that that’s the way forward!

Andrew Vickers @vickersbiostats.bsky.social · Dec 16

Very nice summary recommendations on how to evaluate a prediction model from a group of top researchers in the field.

Stefan Schandelmaier @sschandelmaier.bsky.social · Dec 17

Great! Will include it in @lightsdatabase.bsky.social

Reposted by Stefan Schandelmaier

Andrew Vickers @vickersbiostats.bsky.social · Dec 16

Very nice summary recommendations on how to evaluate a prediction model from a group of top researchers in the field.

Reposted by Stefan Schandelmaier

Miguel Hernan @miguelhernan.org · Nov 26

Does #randomization ensures balance of risk factors between groups? Consider this:

In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)

Reposted by Stefan Schandelmaier

hakwan lau @hakwan.bsky.social · Nov 26

www.theguardian.com/technology/2...

hats off to @deevybee.bsky.social . my highest respect.

Oxford scientist resigns from Royal Society over Elon Musk’s continuing fellowship

Prof Dorothy Bishop said fellowship was ‘a contradiction of all the values’ of UK’s national academy of sciences

www.theguardian.com

Reposted by Kevin McManus, Stefan Schandelmaier

Research on Research Institute (RoRI) @rorinstitute.bsky.social · Nov 18

Launching this week, MetaROR will be a free, open platform where anyone working with metaresearch can share their work and receive transparent, open peer reviews.

Join us at one of our launch events to find out more: researchonresearch.org/metaror-laun...

Reposted by Stefan Schandelmaier

The HPS Podcast @hpspodcast.bsky.social · Nov 13

"We need to get [scientists] to realise that history and philosophy of science has much to contribute to science itself"

A highly quotable episode with Editor-in-Chief of Science @holdenthorp.bsky.social

Out on @hpspodcast.bsky.social now!

#hps #philsci #histsci #sts🧪

S4 Ep 9 - Holden Thorp on 'Teach History and Philosophy of Science' - The HPS Podcast - Conversations from History, Philosophy and Social Studies of Science

“This is Holden Thorp. I'm the Editor in Chief of Science and thanks to Sam and Carmelina for all they're doing to get the word out about the history and philosophy of science”Today's guest is Holden ...

thehpspodcast.buzzsprout.com

Reposted by Stefan Schandelmaier

Please Follow the Official Guardian Account @guardian-world-rss.bsky.social · Nov 4

Quincy Jones, producer and entertainment powerhouse, dies aged 91

Quincy Jones, producer and entertainment powerhouse, dies aged 91

Widely and wildly talented musician and industry mogul worked with Michael Jackson, Frank Sinatra, Will Smith and others

www.theguardian.com

Stefan Schandelmaier @sschandelmaier.bsky.social · Oct 31

Hi qualitative researchers!

For my teaching, I was searching for something like PICO for qualitative. I found SPIDER and like it! pubmed.ncbi.nlm.nih.gov/22829486/

Is anybody aware of any other scheme for systematic question / problem / objective formulation in a qualitative study?

Reposted by Stefan Schandelmaier

Darren Dahly @statsepi.bsky.social · Oct 27

For patient-focused research, there are very few useful research aims, and none of them are "identifying risk factors.”

Seriously! 😜

(ICYMI)

statsepi.substack.com/p/sorry-what...

Sorry, what was the question again?

And again. And again. And again...

statsepi.substack.com

Stefan Schandelmaier @sschandelmaier.bsky.social · Oct 3

Did you just present new #TrialsMethodology guidance at #ICTMC2024? Have a look at our new database and check whether it is already in it. If not, send it along!
lights.science

Homepage - LIGHTS

The Library of Guidance for Health Scientists. A living database for methods guidance.