Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.

Within the infected host, influenza A virus has a bipartite existence as intracellular viral genomic segments undergoing replication and assembly into progeny particles and extracellular progeny parti...

Alphaviruses are mosquito-borne pathogens causing rheumatological disease and encephalomyelitis. Their spread, enhanced by climate change, presents a growing global health threat. To date, no specific treatments and, except for chikungunya virus, no preventive vaccines exist. Alphavirus infection induces cross-reactive antibodies targeting conserved epitopes in glycoprotein E1 and E2. While cross-reactivity can facilitate the development of broad-spectrum vaccines, it complicates serological diagnosis in regions with multiple co-circulating alphaviruses. This review examines how antibody cross-reactivity can foster development of cross-protective vaccines and therapeutics but also how it may present challenges such as antibody-dependent enhancement of disease and diagnostic misinterpretation. Understanding the conservation of epitopes is crucial for designing effective therapies, vaccines, and precise diagnostics to mitigate the alphavirus disease burden globally.

Its support for a flat budget is a sign of congressional resistance to drastic cuts Trump has proposed

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Medicine shortages plus limited testing and hospital capacity exacerbated by withdrawal of USAID as outbreak gathers pace across countries in the region

During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome activity, to produce hos...

Nature Microbiology - During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome...

The upsurge of mpox (formerly known as monkeypox) in Africa and its global spread highlight the need for improved vaccines. The development of new rec…

Interferon is a central component of the vertebrate antiviral immune response, thought to act through induction of hundreds of interferon-stimulated genes, with some redundancy. This Perspective highl...

Communications Physics - Common assumption dictates that an egg exhibits greater structural resistance when dropped on its end rather than on its side. To test this supposition, the authors perform...

In this Review, Weaver and colleagues discuss the transmission cycles of arthritogenic alphaviruses, their vectors, epidemiology, transmission dynamics, evolution, pathophysiology and immune responses...

Two evolutionary strategies allow the antiviral protein MxA to evolve simultaneous super-restriction against multiple viruses.

Reducing federal support for research and development could cause long-run economic damage and reduce government revenue.

Official website of Senator Scott Wiener, representing California Senate District 11.

Viruses have evolved to efficiently navigate host cells to deliver, express, and replicate their genetic material. Understanding the mechanisms underlying viral RNA localisation is paramount to design...