Tom Chad
@tomchad.bsky.social
New here. Anaesthetic registrar. PhD student. Wannabe Clinician/Scientist. Green doughnut chaser.
Reposted by Tom Chad
SGLT2 and postop outcomes
There were significantly higher event-free survival probabilities for all-cause mortality, major adverse cardiovascular events, acute kidney injury and ketoacidosis in patients in the SGLT2 inhibitor group compared with controls
#AnSKy
doi.org/10.1111/anae...
There were significantly higher event-free survival probabilities for all-cause mortality, major adverse cardiovascular events, acute kidney injury and ketoacidosis in patients in the SGLT2 inhibitor group compared with controls
#AnSKy
doi.org/10.1111/anae...
October 17, 2025 at 10:03 AM
SGLT2 and postop outcomes
There were significantly higher event-free survival probabilities for all-cause mortality, major adverse cardiovascular events, acute kidney injury and ketoacidosis in patients in the SGLT2 inhibitor group compared with controls
#AnSKy
doi.org/10.1111/anae...
There were significantly higher event-free survival probabilities for all-cause mortality, major adverse cardiovascular events, acute kidney injury and ketoacidosis in patients in the SGLT2 inhibitor group compared with controls
#AnSKy
doi.org/10.1111/anae...
I think this came up in a recent FRCA SOE, so might be useful;
How do sauropods overcome large dead space volumes from having 10m long necks?
www.bbc.co.uk/sounds/play/...
How do sauropods overcome large dead space volumes from having 10m long necks?
www.bbc.co.uk/sounds/play/...
In Our Time - The Evolution of Lungs - BBC Sounds
From the mechanics of the first breaths on Earth to the reason we hiccup.
www.bbc.co.uk
June 18, 2025 at 8:24 AM
I think this came up in a recent FRCA SOE, so might be useful;
How do sauropods overcome large dead space volumes from having 10m long necks?
www.bbc.co.uk/sounds/play/...
How do sauropods overcome large dead space volumes from having 10m long necks?
www.bbc.co.uk/sounds/play/...
Reposted by Tom Chad
ZODIAC trial: For ischemic stroke patients who are awaiting thrombectomy, flat positioning reduced the risk of neuroworsening or death
Premature termination but seems reasonable
Statistically robust results
Best available evidence; should change practice
pubmed.ncbi.nlm.nih.gov/40465238/ #EMIMCC
Premature termination but seems reasonable
Statistically robust results
Best available evidence; should change practice
pubmed.ncbi.nlm.nih.gov/40465238/ #EMIMCC
June 9, 2025 at 4:33 PM
ZODIAC trial: For ischemic stroke patients who are awaiting thrombectomy, flat positioning reduced the risk of neuroworsening or death
Premature termination but seems reasonable
Statistically robust results
Best available evidence; should change practice
pubmed.ncbi.nlm.nih.gov/40465238/ #EMIMCC
Premature termination but seems reasonable
Statistically robust results
Best available evidence; should change practice
pubmed.ncbi.nlm.nih.gov/40465238/ #EMIMCC
Reposted by Tom Chad
PhD student sends me this. Ouch.
!["PhD supervisors have two moods: [picture of heavily altered essay with red lines everywhere] [picture of guy with thumb up]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:zq2dj4isij7fkgxdaq4objoj/bafkreibi2mia4kpmjtdia64rkuncad5o6p37stm3iqxsygcb3ggi7wl4gy@jpeg)
April 13, 2025 at 6:31 PM
PhD student sends me this. Ouch.
Keeping fingers crossed for the methylene blue collection 🤞
March 26, 2025 at 4:16 PM
Keeping fingers crossed for the methylene blue collection 🤞
Reposted by Tom Chad
Results of the #SESARtrial:
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
March 18, 2025 at 8:38 AM
Results of the #SESARtrial:
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.
Now published in JAMA jamanetwork.com/journals/ja...
@isicem.bsky.social #ISICEM25
Reposted by Tom Chad
Follow #CardioSky community by using starter packs
🦋 Cardiology Journals & Societies
go.bsky.app/FfE1QRm
🦋 CardioSky I
go.bsky.app/562nfhZ
🦋 CardioSky II
go.bsky.app/R2XckyG
🦋 Cardiology Journals & Societies
go.bsky.app/FfE1QRm
🦋 CardioSky I
go.bsky.app/562nfhZ
🦋 CardioSky II
go.bsky.app/R2XckyG
March 13, 2025 at 7:58 PM
Follow #CardioSky community by using starter packs
🦋 Cardiology Journals & Societies
go.bsky.app/FfE1QRm
🦋 CardioSky I
go.bsky.app/562nfhZ
🦋 CardioSky II
go.bsky.app/R2XckyG
🦋 Cardiology Journals & Societies
go.bsky.app/FfE1QRm
🦋 CardioSky I
go.bsky.app/562nfhZ
🦋 CardioSky II
go.bsky.app/R2XckyG
Is it sad I’ve already named my career defining clinical trial (which someone will probably do before me) with one of those dodgy acronym titles
March 12, 2025 at 10:43 PM
Is it sad I’ve already named my career defining clinical trial (which someone will probably do before me) with one of those dodgy acronym titles
Another very good episode www.bbc.co.uk/sounds/play/...
The Life Scientific - Sir Magdi Yacoub on pioneering heart transplant surgery - BBC Sounds
Professor Sir Magdi Yacoub discusses his career at the cutting edge of transplant surgery.
www.bbc.co.uk
March 10, 2025 at 6:03 PM
Another very good episode www.bbc.co.uk/sounds/play/...
Very good trip to the Institut für Pathophysiologie @unidue.bsky.social to see their setup and learn lots of #langendorff
March 7, 2025 at 4:39 PM
Very good trip to the Institut für Pathophysiologie @unidue.bsky.social to see their setup and learn lots of #langendorff
Reposted by Tom Chad
In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
Mysterious Blobs in Cells Are Changing the Way We Understand Life
Tiny specks called biomolecular condensates are leading to a new understanding of the cell
www.scientificamerican.com
January 21, 2025 at 5:43 PM
In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...
Sat in lab meeting recently fairly sure I was the most stupid person in the room. I hear it’s supposed to be a good thing but it was hard work 😮💨
January 15, 2025 at 5:33 PM
Sat in lab meeting recently fairly sure I was the most stupid person in the room. I hear it’s supposed to be a good thing but it was hard work 😮💨
Another insightful episode. I love these mostly because they often describe the hiccups and failures along the way, although listening to this Tim is supremely impressive. And yes I did try and fail at astronaut selection 👩🚀
podcasts.apple.com/gb/podcast/t...
podcasts.apple.com/gb/podcast/t...
podcasts.apple.com
January 4, 2025 at 10:01 AM
Another insightful episode. I love these mostly because they often describe the hiccups and failures along the way, although listening to this Tim is supremely impressive. And yes I did try and fail at astronaut selection 👩🚀
podcasts.apple.com/gb/podcast/t...
podcasts.apple.com/gb/podcast/t...
Reposted by Tom Chad
#SGLT2i use in critical care, icu-- interesting read
#SGLT2 inhibitors
#cardiosky #pharmsky #chf
link.springer.com/article/10.1...
#SGLT2 inhibitors
#cardiosky #pharmsky #chf
link.springer.com/article/10.1...
How to manage sodium-glucose cotransporter-2 inhibitors in the critically ill patient? - Intensive Care Medicine
Intensive Care Medicine -
link.springer.com
December 19, 2024 at 4:19 PM
#SGLT2i use in critical care, icu-- interesting read
#SGLT2 inhibitors
#cardiosky #pharmsky #chf
link.springer.com/article/10.1...
#SGLT2 inhibitors
#cardiosky #pharmsky #chf
link.springer.com/article/10.1...
go.bsky.app/4SkorDV
Have had a go at collating pack for those with #AnSky #intensivecaremedicine #criticalcare #anaesthetic #ICM and more general #research interests
Have had a go at collating pack for those with #AnSky #intensivecaremedicine #criticalcare #anaesthetic #ICM and more general #research interests
December 12, 2024 at 9:49 PM
go.bsky.app/4SkorDV
Have had a go at collating pack for those with #AnSky #intensivecaremedicine #criticalcare #anaesthetic #ICM and more general #research interests
Have had a go at collating pack for those with #AnSky #intensivecaremedicine #criticalcare #anaesthetic #ICM and more general #research interests
I like this idea of creating starling curves with increasing balloon volume in #Langendorff model
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
Bioengineered mouse models have become powerful research tools in determining causal relationships between molecular alterations and models of cardiovascular disease. Although molecular biology is nec...
pmc.ncbi.nlm.nih.gov
December 4, 2024 at 9:22 PM
I like this idea of creating starling curves with increasing balloon volume in #Langendorff model
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
When you think something might be a good idea only to find out someone has not only thought of it but developed kit/protocol/tested it clinically! Interesting preliminary work on ‘controlled automated reperfusion of the whole body’ (CARL) www.jtcvsopen.org/article/S266...
Application of cardiac surgery techniques to improve the results of cardiopulmonary resuscitation after cardiac arrest: Controlled automated reperfusion of the whole body
Until now, the overall results (survival and neurologic outcome) of cardiopulmonary
resuscitation (CPR) after cardiac arrest (CA) have been quite dismal. They have improved
when compared with the outc...
www.jtcvsopen.org
December 3, 2024 at 5:22 PM
When you think something might be a good idea only to find out someone has not only thought of it but developed kit/protocol/tested it clinically! Interesting preliminary work on ‘controlled automated reperfusion of the whole body’ (CARL) www.jtcvsopen.org/article/S266...
May have forgotten to add the tetrazolium to my tetrazolium assay
November 27, 2024 at 7:47 PM
May have forgotten to add the tetrazolium to my tetrazolium assay
Reposted by Tom Chad
Now that we are all here….this is a challenging paper- have we got cellular energetics under stress all wrong? www.nature.com/articles/s41...
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature
Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...
www.nature.com
November 21, 2024 at 8:17 PM
Now that we are all here….this is a challenging paper- have we got cellular energetics under stress all wrong? www.nature.com/articles/s41...
Reposted by Tom Chad
Try this pubmed.ncbi.nlm.nih.gov/38907106/
Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients - PubMed
General Anaesthesia (GA) is accompanied by a marked decrease in sympathetic outflow and thus loss of vasomotor control of cardiac preload. The use of vasoconstriction during GA has mainly focused on m...
pubmed.ncbi.nlm.nih.gov
November 18, 2024 at 12:29 PM
Try this pubmed.ncbi.nlm.nih.gov/38907106/
Reposted by Tom Chad
Check out our new educational hemodynamic adventure! We’ll add a new chapter every few weeks. #emimcc
Hello all! On behalf of the editors, @maxhockstein.bsky.social and @zentensivist.bsky.social, we’d like to announce the launch of our living textbook for hemodynamics, shockwaves.icu! #emimcc
November 18, 2024 at 2:20 PM
Check out our new educational hemodynamic adventure! We’ll add a new chapter every few weeks. #emimcc
Reposted by Tom Chad
A few years ago I posted this thread in the other place, reflecting on my PhD journey whilst prepping for my viva. Thought I should post it here now we are moving to Bluesky. Hopefully it's useful for aspiring researchers!
Reflections on taking time out of clinical training to pursue research: 1/n
Reflections on taking time out of clinical training to pursue research: 1/n
November 18, 2024 at 7:17 AM
A few years ago I posted this thread in the other place, reflecting on my PhD journey whilst prepping for my viva. Thought I should post it here now we are moving to Bluesky. Hopefully it's useful for aspiring researchers!
Reflections on taking time out of clinical training to pursue research: 1/n
Reflections on taking time out of clinical training to pursue research: 1/n
Hopefully 1st bit of solo data collection tomorrow 📊
November 17, 2024 at 4:06 PM
Hopefully 1st bit of solo data collection tomorrow 📊