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Reposted by Toth-Petroczy lab

Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 10d

Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...

New Perspectives on the Hidden World of Proteins

 Schering Young Investigator Award 2025 goes to Agnes Toth-Petroczy

www.mpi-cbg.de

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Elisha Krieg @elishakrieg.bsky.social · 25d

AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it.

Commentary in @natnano.nature.com

#nanotechnology

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Human Technopole @humantechnopole.bsky.social · Jul 24

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com
▶️ @ssp2025.bsky.social

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · Jun 26

Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...

Novel Research in Biological Artificial Intelligence

Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.

www.mpi-cbg.de

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Nature @nature.com · Jul 3

Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen

https://go.nature.com/40wXMx6

How we’re rebuilding the Weizmann Institute — and our hopes for a better future

Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.

go.nature.com

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Physics of Life Dresden @poldresden.bsky.social · Jun 18

Big news 🎉 We are excited to announce the new TUD graduate school "Biomolecular Condensates: From Physics to Biological Functions", with 12 members from PoL! Through this school, we will train a new generation of scientists working on #condensates at the interphase between theory and experiments 🤓⤵️

TU Dresden @tudresden.bsky.social · Jun 16

Hochaktuelles Themenfeld an der Schnittstelle von Physik, Biologie und Polymerforschung: Die @dfg.de fördert ab 2026 mit rund 7 Millionen Euro ein neues Graduiertenkolleg zur Erforschung biomolekularer Kondensate in #Dresden. 🔬
ℹ️ tu-dresden.de/tu-dresden/n...

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CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · Jun 11

The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩

Big #thankyou to all the participants from
@hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · May 28

Related science sketch video by @marionamec.bsky.social www.youtube.com/watch?v=0REv...

Condensates Inside Condensates—Triggering Disease?

YouTube video by MPI-CBG

www.youtube.com

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Toth-Petroczy lab @tothpetroczylab.bsky.social · May 28

Congratulations to the amazing team of Chi Fung Willis Chow, @mscheremetjew.bsky.social, Soumyadeep Ghosh, @annaha-poetry-art.bsky.social and HongKee and Lena from the Scientific Computing Facility @mpi-cbg.de! 🎉

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Toth-Petroczy lab @tothpetroczylab.bsky.social · May 28

Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...

SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions

Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions

doi.org

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Physics of Life Dresden @poldresden.bsky.social · May 21

One week left to apply to the Physics of Life MSc this year! Students learn first-class research skills and can also avail of #scholarships to aid their studies.

Learn more and apply: physics-of-life.tu-dresden.de/career-educa...

#internationalstudents #MSc #EnglishMSc #Physics #studyabroad

TUD | Center for Molecular and Cellular Bioengineering (CMCB) @cmcb-tud.bsky.social · Apr 22

Good news: there will be 3 scholarships available for Physics of Life MSc students starting in 2025!

✅ €300/month for 1 year
✅ No separate application—admitted students are automatically considered.

Apply now ➡️ tud.link/vejrmx

#Biophysics #PhysicsofLife #StudyinGermany #Masters #Biology

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Ksenia Kuznetsova @kkuznetsova.bsky.social · Apr 28

Exciting that CD-CODE is now connected to THE go-to resource for everything protein-related!

It's a great step forward, directing further developments and outlook for our project @tothpetroczylab.bsky.social @mscheremetjew.bsky.social 🥳

CrowDsourcing COndensate Database & Encyclopedia @cdcode.bsky.social · Apr 28

We're really excited that CD-CODE is now cross-referenced by #UniProt and has already been included in the latest release: www.uniprot.org/release-note...

Spreading knowledge about #biomolecular #condensates 🥳

@ebi.embl.org @sib.swiss @mpi-cbg.de @tothpetroczylab.bsky.social @hymanlab.bsky.social

UniProt

UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.

www.uniprot.org

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

We conclude that new IDR-specific features and paradigms are needed to accurately classify disease mutations within those regions. Disorder-to-order transitions predicted by AlphaFold3 and motif predictions (e.g. by SHARK-capture) may aid structure-based variant interpretation.

Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

The distance to the second Methionine discriminates between pathogenic and benign variants associated with the N-Methionine site.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

Mutations at the N-Methionine site are prevalent. Look at the surprisingly high peak at position 1.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

Most mutations in disordered regions are benign but ~12% of pathogenic mutations fall within a disordered region.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

The correlation between the disorder predictors is low.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

It depends which disorder definition (score) is used. Only 7% of residues are consistently predicted as disordered across five different disorder prediction tools. flDPnn under predicts disorder compared to other methods.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

State-of-the-art VEPs tools have lower sensitivity but higher specificity for variants in disordered regions.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Apr 16

Deep learning tools predict variants in disordered regions with lower sensitivity. Just published by FedericaLuppino, @swlenz.bsky.social and WillisChow @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social bmcgenomics.biomedcentral.com/articles/10....

Deep learning tools predict variants in disordered regions with lower sensitivity - BMC Genomics

Background The recent AI breakthrough of AlphaFold2 has revolutionized 3D protein structural modeling, proving crucial for protein design and variant effects prediction. However, intrinsically disorde...

bmcgenomics.biomedcentral.com

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · Apr 14

New Publication of the @tothpetroczylab.bsky.social: The group found that prediction tools are less sensitive in intrinsically disordered regions of proteins (IDRs). Since they are common & important, new methods tailored to these regions are needed. bmcgenomics.biomedcentral.com/articles/10....

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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · Mar 25

The @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...

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Irina Bezsonova @irinabezsonova.bsky.social · Mar 15

You can download my protein structure-inspired artwork from pdb webpage:

pdb101.rcsb.org/sci-art/bezs...

@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart

PDB101: Irina Bezsonova Gallery

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Mar 18

Proteome-wide predictions of motifs in S. cerevisiae are available. Matches to ELM motifs, UniProt motifs, and mutagenesis sites (UniProt) are enriched in SHARK-motifs compared to the random control. An example output: SHARK-capture score plot for Sic1.

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Toth-Petroczy lab @tothpetroczylab.bsky.social · Mar 18

SHARK-capture identifies a highly conserved motif (in pink) amongst Ded1p orthologs which regulates ATPase activity. Interestingly, AlphaFold2 predicts close proximity between the motif and the helices core.

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