Thank you Gates Foundation for believing in our work. This is a strong acknowledgment of our standing in the field — and a boost to our vision: to move lab findings into impactful solutions for people living with Environmental Enteric Dysfunction.

#EED #GlobalHealth

Patients with ileal Crohn's carry diminished levels of MUC17 a membrane mucin demonstrated to protect the small intestine against bacteria in a preclinical mouse model, @tpelaseyed.bsky.social et al.
https://insight.jci.org/articles/view/181481

Remarkable! Check out figure below.

“We find that when ants work in groups, their performances rise significantly. Groups of people do not show such improvement and, when their communication is restricted, even display deteriorated performances. “

IG Nobel nomination?

🎄 Santa came early this year!🎄

We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges.

insight.jci.org/articles/vie...

#mucins #glycotime #Crohns #gut

"Polls have shown that principal investigator biologists now spend up to 40 percent of their time—it’s a shocking number, 40 percent of their time—writing grants."

www.harvardmagazine.com/2025/01/harv...

Academic Christmas

Overdue: Progress report
18 Dec: Supervisor report I
18 Dec: Supervisor report II
18 Dec: Supervisor report III
9 Jan: Grant deadline
9 Jan: Grant deadline II
10 Jan: Grant deadline III
16 Jan: Panel meeting, 14 applications
27 Jan: Grant deadline IV
1 Feb: Grant deadline V

🎅🎄😕

Synchronized filopodial formation for
#FluorescenceFriday 💥
#CellBiology #Microscopy @vucellimaging.bsky.social

How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime

Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...

#WeekendRead #FungiPower! Liao Gao Iliev &co show @ Nature that the stomach of wild, not lab, mice is colonized by an immunosilent fungus! Mucus alterations via diet or antibiotics drive a Th2 -not Th17- response that worsens allergy but protects against parasites! doi.org/10.1038/s41586-024-08213-2

#mucus #gobletcell #mucin starterpack now up and running! It's a short list so far so please let me know if you want to be added to it 🦠
go.bsky.app/7Z84CmG

In politics clarity is its own opportunity. The storm of the 2024 election has created great clarity. The richest man in the world, Elon Musk, and 3rd richest man in the world, Jeff Bezos, are currently asking a group of Trump judges to end the right to organize & join a union in the United States.

My new book, Everything Is Tuberculosis, explores the history of our deadliest infectious disease. It's also about our horrifying present: TB still kills kills over a million people per year, even though it's been curable since the 1950s.

Signed copies can be ordered at everythingistb.com

Seems that @biorxivpreprint.bsky.social ought to consider adding links to @bsky.app posts given the mass transfer of scientists from Twitter to @bsky.app that is taking place.

This paper came out 1 mo ago. The spirochete #Brachyspira pilosicoli is a commensal linked to #IBS, diarrhea & abdominal pain. But how it latches on to the colonic epithelium during infection remained a mystery. We identified the interaction mechanism! #glycotime

www.tandfonline.com/doi/full/10....

I am very proud of this paper, currently under revision. Very few labs have set out to define the function of membrane mucins outside the context of cancer.

Here we defined the regiospecific function of membrane mucin MUC17 in the intestine.

www.biorxiv.org/content/10.1...

#glycotime #mucin

We rang in #2022 by introducing a new member of the mucin (MUC) family, MUC3B that joined 3 already annotated membrane mucin genes clustered together on the human chromosome 7q22! journals.plos.org/plosone/arti... #mucins #glycotime

In our paper from 2021, we identified membrane mucin MUC17 as the major component of the small intestinal glycocalyx, which protects the enterocytes against direct bacterial encounters. www.cell.com/cell-reports... #glycotime #mucin #intestine

Late adopter right here.

In my first couple of posts (is that what they are called on this platform?), I’ll share some of our work from the recent years.