Traver Hart
@traver.bsky.social
Assoc Prof, MD Anderson. Functional genomics, CRISPR/Cas12a genetic interactions & synthetic lethality, history, politics, snark.
Reposted by Traver Hart
Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.
November 19, 2025 at 4:58 PM
Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.
Adaptive behavior of predatory publisher "editors" - I was just invited to review one or more of a list of five articles, each submitted to different journals. I haven't seen that before.
October 9, 2025 at 3:14 PM
Adaptive behavior of predatory publisher "editors" - I was just invited to review one or more of a list of five articles, each submitted to different journals. I haven't seen that before.
NCI R01 NOA received. Long, long exhale.
September 9, 2025 at 5:54 PM
NCI R01 NOA received. Long, long exhale.
Life goals updated. Source: www.reddit.com/r/OldSchoolR...
September 5, 2025 at 7:18 PM
Life goals updated. Source: www.reddit.com/r/OldSchoolR...
I can withdraw from social media now. I have learned everything worth learning.
Ok its ‘feed it off an aux, speak, grunt no strength, the ladder start to clatter with fear fight down height, wire in a fire representing seven games, a government for hire and a combat site’.
September 5, 2025 at 4:17 AM
I can withdraw from social media now. I have learned everything worth learning.
Ruin a movie by making it about Gary
The Cook, The Thief, His Wife, and Gary
The Cook, The Thief, His Wife, and Gary
Ruin a movie by making it about Gary
Dances With Gary
Dances With Gary
Ruin a movie by making it about Gary.
Charlie and the Gary Factory
Charlie and the Gary Factory
September 4, 2025 at 12:37 PM
Ruin a movie by making it about Gary
The Cook, The Thief, His Wife, and Gary
The Cook, The Thief, His Wife, and Gary
Ironically, it's not even in the Midwest.
"Midwestern State University" oh ok yeah sure that's a real school. I majored in Academic Subject at Midwestern State University and rushed Fraternity. Some of my best memories were nights with friends at Student Bar.
September 1, 2025 at 4:26 PM
Ironically, it's not even in the Midwest.
Reposted by Traver Hart
Reposted by Traver Hart
Reposted by Traver Hart
We acknowledge that no one has the bandwidth for this, but if it helps:
- It’s ‘voilà,’ not ‘wallah!’
- It’s ‘a lot,’ not ‘alot.’
- It’s ‘further ado,’ not ‘farther adieu.’
- It’s ‘flesh out,’ not ‘flush out.’
- It’s ‘sneak peek,’ not ‘sneak peak.’
No worries if not!!!
- It’s ‘voilà,’ not ‘wallah!’
- It’s ‘a lot,’ not ‘alot.’
- It’s ‘further ado,’ not ‘farther adieu.’
- It’s ‘flesh out,’ not ‘flush out.’
- It’s ‘sneak peek,’ not ‘sneak peak.’
No worries if not!!!
August 26, 2025 at 2:03 PM
We acknowledge that no one has the bandwidth for this, but if it helps:
- It’s ‘voilà,’ not ‘wallah!’
- It’s ‘a lot,’ not ‘alot.’
- It’s ‘further ado,’ not ‘farther adieu.’
- It’s ‘flesh out,’ not ‘flush out.’
- It’s ‘sneak peek,’ not ‘sneak peak.’
No worries if not!!!
- It’s ‘voilà,’ not ‘wallah!’
- It’s ‘a lot,’ not ‘alot.’
- It’s ‘further ado,’ not ‘farther adieu.’
- It’s ‘flesh out,’ not ‘flush out.’
- It’s ‘sneak peek,’ not ‘sneak peak.’
No worries if not!!!
Reposted by Traver Hart
IN CASE OF FIRE:
1) If someone is on fire, punch them in the face.
2) Cop a feel off the person behind you, as these might be your last minutes on Earth.
3) Squeeze the junk of the person in front of you. It'll slow them down, allowing you to move ahead of them.
4) Exit.
1) If someone is on fire, punch them in the face.
2) Cop a feel off the person behind you, as these might be your last minutes on Earth.
3) Squeeze the junk of the person in front of you. It'll slow them down, allowing you to move ahead of them.
4) Exit.
August 20, 2025 at 12:53 PM
IN CASE OF FIRE:
1) If someone is on fire, punch them in the face.
2) Cop a feel off the person behind you, as these might be your last minutes on Earth.
3) Squeeze the junk of the person in front of you. It'll slow them down, allowing you to move ahead of them.
4) Exit.
1) If someone is on fire, punch them in the face.
2) Cop a feel off the person behind you, as these might be your last minutes on Earth.
3) Squeeze the junk of the person in front of you. It'll slow them down, allowing you to move ahead of them.
4) Exit.
Reposted by Traver Hart
TIL the original paper describing CRISPR, by Francisco Mojica, was rejected by 4 journals and took 2 years to be published
![CRISPR as a microbial immune system
In 2003, Mojica wrote the first paper suggesting that CRISPR was an innate microbial immune system. The paper was rejected by a series of high-profile journals, including Nature, Proceedings of the National Academy of Sciences, Molecular Microbiology and Nucleic Acids Research, before finally being accepted by Journal of Molecular Evolution in February, 2005.[3][4]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:73aicoale2mqwrap63rdzwep/bafkreibu3dburfn527r3sbu2ov6y7gebv6zopaznagnfytjtsn6y4k7cs4@jpeg)
August 17, 2025 at 4:00 AM
TIL the original paper describing CRISPR, by Francisco Mojica, was rejected by 4 journals and took 2 years to be published
Reposted by Traver Hart
Come be my boss! My dept. at GT is searching for a new chair. Drop me a line if you are interested, I'd be happy to talk about this position, GT, ATL- anything. It's a drama-free department filled with cool people in a dynamic city.
www.biosciences.gatech.edu/chair-search
www.biosciences.gatech.edu/chair-search
Chair Search
Chair, School of Biological Sciences Georgia Institute of Technology, Atlanta The School of Biological Sciences of the Georgia Institute of Technology (“Georgia Tech”) invites applications for the pos...
www.biosciences.gatech.edu
August 13, 2025 at 11:19 PM
Come be my boss! My dept. at GT is searching for a new chair. Drop me a line if you are interested, I'd be happy to talk about this position, GT, ATL- anything. It's a drama-free department filled with cool people in a dynamic city.
www.biosciences.gatech.edu/chair-search
www.biosciences.gatech.edu/chair-search
Today I learned a new word: zebra
Zero
Evidence
But
Really
Arrogant
Zero
Evidence
But
Really
Arrogant
August 13, 2025 at 2:28 PM
Today I learned a new word: zebra
Zero
Evidence
But
Really
Arrogant
Zero
Evidence
But
Really
Arrogant
And all those people have kept the biggest secret in human history for all those years. 🙄
Various credible sources claim that the CIA and DoD have conducted covert UFO retrieval, tracking, and exploitation since at least World War II, operating through a complex network of U.S. and allied missions, defense contractor analysis, and interagency secrecy spanning decades.
CIA and DoD Engaged in Decades-Long Retrieval, Tracking and Exploitation of UFOs, Including Italian ‘Magenta Craft,’ Sources Reveal — Liberation Times | Reimagining Old News
With a potentially explosive Unidentified Anomalous Phenomena (UAP) hearing set to take place in the House of Representatives next week, sources connected with the Intelligence Community and Departmen...
www.liberationtimes.com
August 12, 2025 at 1:13 AM
And all those people have kept the biggest secret in human history for all those years. 🙄
Reposted by Traver Hart
NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at:
osp.od.nih.gov/comment-form....
osp.od.nih.gov/comment-form....
August 11, 2025 at 11:30 PM
NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at:
osp.od.nih.gov/comment-form....
osp.od.nih.gov/comment-form....
Reposted by Traver Hart
I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.
August 11, 2025 at 6:12 PM
I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.
I love this. Interesting but imperfect parallels with quantitative biology.
When I was in a software hiring role, I looked for those with majors in art, English, religion or other humanities, with a minor in CompSci or who just liked to code on the side. I wanted creators and explainers. It's easier to teach a pure thinker to code than to teach a pure coder to think.
August 10, 2025 at 10:34 PM
I love this. Interesting but imperfect parallels with quantitative biology.
Reposted by Traver Hart
We released a new version of ActivePathways for directional integration of multiomics datasets. V2.0.6 includes methods to compare directional & non-directional analyses to find candidate genes & pathways lost or gained when directionality is accounted for: github.com/reimandlab/A... led by @mslob95
GitHub - reimandlab/ActivePathways: Integrative pathway enrichment analysis of multivariate omics data
Integrative pathway enrichment analysis of multivariate omics data - reimandlab/ActivePathways
github.com
August 9, 2025 at 4:42 PM
We released a new version of ActivePathways for directional integration of multiomics datasets. V2.0.6 includes methods to compare directional & non-directional analyses to find candidate genes & pathways lost or gained when directionality is accounted for: github.com/reimandlab/A... led by @mslob95
Reposted by Traver Hart
Washington Post: “Is fascism bad? The answer may surprise you”
Teen Vogue: “Here are three fun tips you can use this summer to disable an armored personnel carrier”
Teen Vogue: “Here are three fun tips you can use this summer to disable an armored personnel carrier”
August 6, 2025 at 12:28 PM
Washington Post: “Is fascism bad? The answer may surprise you”
Teen Vogue: “Here are three fun tips you can use this summer to disable an armored personnel carrier”
Teen Vogue: “Here are three fun tips you can use this summer to disable an armored personnel carrier”
Reposted by Traver Hart
"feckless fucks as far as the eye can see," the name of my new album
August 7, 2025 at 12:53 PM
"feckless fucks as far as the eye can see," the name of my new album
Really not sure where this incoming class of life sciences grad students is going to find labs. Funding cuts means labs are inevitably getting smaller and the biotech job pipeline has shut down so people aren't as eager to leave. Slow motion train wreck.
August 6, 2025 at 3:32 PM
Really not sure where this incoming class of life sciences grad students is going to find labs. Funding cuts means labs are inevitably getting smaller and the biotech job pipeline has shut down so people aren't as eager to leave. Slow motion train wreck.
Reposted by Traver Hart
Reminder! Tenure track position in Genetics at Trinity College Dublin! Come join us, we're nice... 😊 Please repost! 🙏
Very pleased to say we have an Assistant Professor job opening (tenure track) in the Department of Genetics at Trinity College Dublin! 😀
www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!
www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!
July 29, 2025 at 11:52 AM
Reminder! Tenure track position in Genetics at Trinity College Dublin! Come join us, we're nice... 😊 Please repost! 🙏
Reposted by Traver Hart
Have $10M and want to cure some diseases?
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
August 5, 2025 at 12:06 PM
Have $10M and want to cure some diseases?
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
This is so, so important to show. Thanks for your efforts.
Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉
www.nature.com/articles/s41...
We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!
🧵
www.nature.com/articles/s41...
We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!
🧵
August 4, 2025 at 3:09 PM
This is so, so important to show. Thanks for your efforts.