Lightnews — Scholar-powered news

Reposted by Vishal Mohanakrishnan

Nature Cardiovascular Research @natcardiovascres.nature.com · Jul 15

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!

www.nature.com/natcardiovas...

5 10

Reposted by Vishal Mohanakrishnan

Makinen lab - Lymphatic Biology and Pathology @taijamakinenlab.bsky.social · Jul 1

I am honoured to be elected as a Member of EMBO and look forward to contributing to its mission and community!

EMBO @embo.org · Jul 1

Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪

Learn more here:
www.embo.org/press-releas... #EMBOMembers2025

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO

Sixty-nine new members join the community of leading life scientists in Europe and beyond

www.embo.org

5 4 19

Reposted by Vishal Mohanakrishnan

Makinen lab - Lymphatic Biology and Pathology @taijamakinenlab.bsky.social · May 25

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in ‪@natcardiovascres.nature.com by Marle Kraft et al.

rdcu.be/enhST

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations

Nature Cardiovascular Research - Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth...

rdcu.be

1 8 17

Reposted by Vishal Mohanakrishnan

Karina Yaniv @karinayaniv.bsky.social · Mar 25

📢 #GRC_Angiogenesis program is up! We have an amazing lineup of speakers ready to dive into the "social life" of vessels! How they engage with their neighbors, how they connect, and why they break up! Plus we have ~15 slots available for short talks! Apply (link 👇) and see you in Newport in July!

1 15 21

Reposted by Vishal Mohanakrishnan

Hao Yin @haoyin.bsky.social · Mar 21

Not every organ ages the same🤠

With Age, Skull bone marrow Vasculature+HSPC Expand & ⏫ contribution to peripheral leukocyte

Skull BM expands with Pregnancy CML PTH Stroke

@bikohcello.bsky.social
@vishalmkrishnan.bsky.social
@ralfhadams.bsky.social
@nature.com 2024
www.nature.com/articles/s41...

4 16

Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · Mar 20

I am a bit biased, but check out the beautiful work and thread by @hansschoofs.bsky.social @taijamakinenlab.bsky.social on why lymphatic endothelial cells have their jigsaw puzzle-like shape 😍😍😍

Hans schoofs @hansschoofs.bsky.social · Mar 20

• Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧵

www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature

Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...

www.nature.com

1 5

Reposted by Vishal Mohanakrishnan

Sara Wickstrom @sarawickstrom.bsky.social · Feb 15

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

Cell and Tissue Dynamics (Wickström)

www.mpi-muenster.mpg.de

64 80

Reposted by Vishal Mohanakrishnan

EVBO @evborg.bsky.social · Feb 4

#EVBOSummerSchool 2025: Please help spread the news!
10-11 June 2025 | Biomedicum Helsinki, Finland
Registration will open soon. Stay tuned!
The summer school will be preceded by the excellent and free-of-charge Wihuri Research Symposium on Cardiovascular Biology!

More info buff.ly/42I9fvY

7 7

Reposted by Vishal Mohanakrishnan

Hao Yin @haoyin.bsky.social · Jan 31

Type R capillary #EndothelialCell in Bone
Cav1+ Efnb2+Flt4-Emcn+
B/w Sinusoid EC & Artery
👉Close to trabecular🦴 osteoprogenitor osteoclast
👉Angiocrine SEMA7A+

⏫by #Aging anti-osteoporosis therapy

@vishalmkrishnan.bsky.social l @ralfhadams.bsky.social #NatCellBio 2024
www.nature.com/articles/s41...

2 3 4

Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · Feb 1

Thank you very much @haoyin.bsky.social ! Beautiful summary! 😊🙏

Reposted by Vishal Mohanakrishnan

Nature @nature.com · Jan 13

Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ

https://go.nature.com/3PwtwN2

How the brain cleans itself during deep sleep

Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.

go.nature.com

25 80

Reposted by Vishal Mohanakrishnan

Geert Carmeliet @geertlab.bsky.social · Jan 13

Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes

Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

rdcu.be

3 12 51

Reposted by Vishal Mohanakrishnan

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Dec 31

Aaaaand finally:
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...

Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology

Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

www.nature.com

2 10

Reposted by Vishal Mohanakrishnan

Ondine Cleaver @ondinecleaver.bsky.social · Dec 2

Pleased to share the work of Mitzy Cowdin and others in our lab showing the requirement for the Hippo pathway kinases Lats1 and 2 for endothelial sensing of hemodynamic flow and for vascular remodeling during embryogenesis 🎉🧪

www.biorxiv.org/content/10.1...

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress

Blood vessels in mammalian embryos develop from initial aggregates of endothelial cell (EC) progenitors, which coordinate the opening and stabilization of central vascular lumens, all while under prog...

www.biorxiv.org

3 19 50

Reposted by Vishal Mohanakrishnan

Johanna Joyce @johannajoyce.bsky.social · Nov 25

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

35 600 1.2K

Reposted by Vishal Mohanakrishnan

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Nov 23

🥂Congratulations to @ralfhadams.bsky.social @vishalmkrishnan.bsky.social & co for their new Open Access study in our journal (@naturecellbiology.bsky.social) identifying type R #capillaries and showing their role in trabecular #bone formation in the diaphysis.
www.nature.com/articles/s41...

Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology

Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

www.nature.com

1 2 14

Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · Nov 23

Many thanks for your kind words and support for our work! 😊🙏

1

Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · Nov 22

Happy #FluorescenceFriday

7

Reposted by Vishal Mohanakrishnan

Nature Cell Biology @natcellbio.nature.com · Nov 21

💫NEW: @ralfhadams.bsky.social & co identify a distinct subset of post-arterial #capillaries, termed type R. They show that type R capillaries contribute to trabecular #bone formation in the diaphysis and respond to anti- #osteoporosis treatments.
www.nature.com/articles/s41...

Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology

Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

www.nature.com

3 18

Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · Nov 19

Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍

Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology.

www.nature.com/articles/s41...

1 8 33

Reposted by Vishal Mohanakrishnan

Sébastien Gauvrit @sebgauvrit.bsky.social · Nov 18

Here's a starter pack focusing on cardiovascular research.
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!

go.bsky.app/SgaGkv5

27 19 30