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Reposted by Yassi Aghazadeh

Stem Cell Network @stemcellnetwork.ca · 11d

📢 McGill University is hiring!

The Department of Pharmacology and Therapeutics, with the Meakins-Christie Labs at the RI-MUHC, invites applications for a tenure-track Assistant Professor in Pluripotent Stem Cells in Regenerative Medicine.

Learn more and apply. ➡️ stemcellnetwork.ca/wp-content/u...

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Yassi Aghazadeh @yassiag.bsky.social · 13d

Interesting and impactful new work by Estall lab: “Here, we identify a novel biological pathway downstream of glucagon that promotes the hepatic lipid accumulation associated with fasting” 👇🏽👇🏽👇🏽
#Glucagon #MASLD #Fasting

Jennifer Estall @dnachicken.bsky.social · 13d

I am happy to share the latest preprint from our lab (@ircm.bsky.social, @umontreal.ca, @mcgill.ca) exploring why and how the liver gets fatty when you are fasting, and how this could impact MASLD.

www.biorxiv.org/content/10.1...

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Glucagon-induced PGC-1α4/PPARγ promotes hepatic lipid storage and macrosteatosis in fasting and MASLD

The liver plays a central role in regulating the transition between fasting and feeding states, coordinating glycogen breakdown, gluconeogenesis, fatty acid catabolism, and lipid storage. Disruptions ...

www.biorxiv.org

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Reposted by Yassi Aghazadeh

Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · Aug 21

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health.
🔗 bit.ly/3HGWhX3

🎉 Congratulations to Dr. Jean-François Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research—particularly on cell migration and metastasis—as well as his commitment to collaboration and innovation in health.
A well-deserved recognition! 👏

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Reposted by Yassi Aghazadeh

Ondine Cleaver @ondinecleaver.bsky.social · Aug 13

I’m one of the mentors for this year long internship :) Apply if you have interest in writing and Science Communication. There’s opportunity to get some of your pieces in DB @devbiol.bsky.social!

Apply today!!

Society for Developmental Biology @socdevbio.bsky.social · Aug 12

🚨Only 4 days to apply!!!🚨Join the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries🔬Connect with top mentors & earn $500 to attend the SDB Annual Meeting 🎉! 👉 www.sdbonline.org/science_comm... #SciComm #DevBio

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Yassi Aghazadeh @yassiag.bsky.social · Aug 4

Very proud to share the first review from the lab with contributions of all lab members. Writing this gave our new lab opportunity to read and discuss many papers and grow as a team. www.frontiersin.org/journals/imm...

www.frontiersin.org

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Yassi Aghazadeh @yassiag.bsky.social · Jun 27

Very excited about our project aiming at advancing cell therapies for type 1 diabetes. and very thankful for receiving funding from @stemcellnetwork.ca

Stem Cell Network @stemcellnetwork.ca · Jun 16

🚨 BIG NEWS! SCN announces $33M to advance 36 #RegenerativeMedicine research projects and #ClinicalTrials!

Learn more. ➡️ stemcellnetwork.ca/research/res...

The Stem Cell Network Announces $33M to Advance Regenerative Medicine Research and Clinical Trials

YouTube video by Stem Cell Network - Réseau de cellules souches

youtu.be

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Reposted by Yassi Aghazadeh

Islet Biology Lab - UMH @isletbiologylab.bsky.social · Apr 22

Preza et al. show that a circadian transcription factor specific to maturing stem cell-derived-β cells, DEC1, regulates insulin responsiveness to glucose. 🧪
#PancSky #StemCells

www.biorxiv.org/content/10.1...

DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm

Stem cell-derived islet (SC-islet) organoids offer hope for cell replacement therapy in diabetes, but their immature function remains a challenge. Mature islet function requires the β-cell circadian c...

www.biorxiv.org

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Reposted by Yassi Aghazadeh

Development @dev-journal.bsky.social · Apr 22

Stem cell-based models of early human development

Read this Development at a Glance Article by Lizhong Liu @liliulab.bsky.social and Jun Wu @jun-wu-lab.bsky.social:
journals.biologists.com/dev/article/...

Poster titled Stem cell-based models of early human development

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Reposted by Yassi Aghazadeh

Islet Biology Lab - UMH @isletbiologylab.bsky.social · Apr 9

Bonifacio and Ziegler summarize current evidence and guidance while emphasizing the need for continued research alongside broader screening application in #type1diabetes. 🧪
#PancSky

dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening

Type 1 diabetes is recognized as a chronic disease with a presymptomatic phase that does not require insulin therapy and a clinical phase where insulin treatment becomes necessary. The presymptomati...

dom-pubs.onlinelibrary.wiley.com

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Yassi Aghazadeh @yassiag.bsky.social · Mar 31

A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, alleviates ER stress and reduces beta-cell immunogenicity

www.cell.com/cell/fulltex...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

www.cell.com

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Reposted by Yassi Aghazadeh

Diabetologia @diabetologiajnl.bsky.social · Mar 28

Enterovirus infections may occur throughout the natural history of type 1 #diabetes and may be associated to islet cell HLA-I hyperexpression. @teresarc.bsky.social @sarahibex.bsky.social #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓

Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes - Diabetologia

Aims/hypothesis Earlier studies of pancreases from donors with type 1 diabetes demonstrated enteroviral capsid protein VP1 in beta cells. In the context of a multidisciplinary approach undertaken by t...

link.springer.com

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Yassi Aghazadeh @yassiag.bsky.social · Mar 26

Hao Yin @haoyin.bsky.social · Mar 25

Cdc42 coordinates PDGFRb+ Mural Cell migration proliferation morphogenesis (wrapping filopodia) during postanatal retinal #Angiogenesis👁️

PDGFRb+ mural cell Cdc42 KO🐭➡️
⏫Angiogenic front leakage
⏬Tip cell filopodia
Perturbed arterial patterning

#VasPharma 2025
www.sciencedirect.com/science/arti...

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Reposted by Yassi Aghazadeh

Alex Rubinsteyn @alexr.bsky.social · Mar 25

I've been really hoping someone would do a study like this!

www.mcponline.org/article/S153...

Deleterious knock-outs in the HLA class I antigen processing and presentation machinery induce distinct changes in the immunopeptidome

The human leukocyte antigen (HLA) processing and presentation machinery (APPM) is altered in various diseases and in response to drug treatments. Defects in the machinery may change presentation level...

www.mcponline.org

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Reposted by Yassi Aghazadeh

Christos Karampelias @ckarampelias.bsky.social · Mar 26

Nice discussion on the usefulness of genetic and autoantibody screening in children for T1D

Islet Biology Lab - UMH @isletbiologylab.bsky.social · Mar 24

Bonifacio et al. estimate that a screening approach that uses repeated islet autoantibody testing results in the greatest sensitivity for identifying youth who are in a presymptomatic stage of #type1diabetes.
#PancSky

link.springer.com/article/10.1...

The efficacy of islet autoantibody screening with or without genetic pre-screening strategies for the identification of presymptomatic type 1 diabetes - Diabetologia

Early detection of type 1 diabetes, in its presymptomatic stage, offers significant clinical advantages, including treatment that can delay disease onset. Current screening focuses on identifying isle...

link.springer.com

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Yassi Aghazadeh @yassiag.bsky.social · Mar 23

Happy Persian new year, Norouz, and the beginning of spring! 🌸🪻☀️

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Yassi Aghazadeh @yassiag.bsky.social · Feb 23

Me as well!

Reposted by Yassi Aghazadeh

Robert Screaton @roblab.bsky.social · Feb 19

Today, rising stars @drprentice.bsky.social and @yassiag.bsky.social swing through the 🇨🇦 National #Islet and #Diabetes Course to discuss the latest on vascularizing stem cell-derived islet cells, adipose-islet communication, beta cell proliferation, and more @cirtn.bsky.social

a man holding two cell phones with the words kind of a big deal

ALT: a man holding two cell phones with the words kind of a big deal

media.tenor.com

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Yassi Aghazadeh @yassiag.bsky.social · Feb 19

Honored to have recieved this together with Dr Hoesli and @martinsauvageau.bsky.social

Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · Feb 18

Au cœur de l’innovation biomédicale au Québec!
L’IRCM félicite ses chercheurs Yasaman Aghazadeh et Martin Sauvageau pour un octroi du réseau ThéCell (Réseau de thérapie cellulaire, tissulaire et génique du Québec) pour un projet structurant en ARN thérapeutique. Avec Corinne Hoesli de McGill U.

Au cœur de l’innovation biomédicale au Québec!
L’IRCM félicite ses chercheurs Yasaman Aghazadeh et Martin Sauvageau qui bénéficient d’un octroi du réseau ThéCell (Réseau de thérapie cellulaire, tissulaire et génique du Québec) pour un projet structurant en ARN thérapeutique. Notez que Corinne Hoesli, de l'Université McGill, sera cochercheuse de ces travaux.
La mission du réseau ThéCell est de promouvoir la recherche translationnelle en thérapie cellulaire, tissulaire et génique au Québec, avec une vision de rayonnement international en favorisant la translation vers la clinique des thérapies cellulaires, tissulaires et géniques au profit de la santé de la population.

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Yassi Aghazadeh @yassiag.bsky.social · Feb 12

More cause to celebrate in this anti science climate! Happy international day of women and gender minorities in science 🧬

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Reposted by Yassi Aghazadeh

The Histochemical Society (HCS) and Journal (JHC) @histochemicalsoc.bsky.social · Jan 27

Read the latest Special Topic on Endothelial Cell and Pericyte Homeostasis and Pathogenesis in JHC: "Role of the Pancreatic Islet Microvasculature in Health and Disease."

Click to read for FREE: bit.ly/4fihNMw

#capillary #diabetes #endothelialcell

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Reposted by Yassi Aghazadeh

Jorge Ferrer @jorge-ferrer.bsky.social · Feb 2

Still time to apply!

Applications from US welcome – four years can feel longer or shorter depending on where you are 😉

Jorge Ferrer @jorge-ferrer.bsky.social · Dec 31

📣 Hiring, please forward widely!!

Two postdoc openings to work on genomics of diabetes

1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling

DM if interested

@crg.eu

shorturl.at/O3wMi

shorturl.at/ieyZy

Postdoctoral scientist, gene regulatory mechanisms and diabetes | CRG Online Recruitment Portal

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

shorturl.at

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Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · Dec 19

#RECRUITMENT | Shape Your Future in Biomedical Research
At the IRCM, you can choose the program that best suits you and start your journey towards a rewarding career in research.
The recruitment period runs from December 15, 2024, to January 31, 2025. www.ircm.qc.ca/en/studies
#DrivenByLife

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Reposted by Yassi Aghazadeh

Heiko Lickert @heikolickert.bsky.social · Jan 21

Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉

meetings.embo.org/event/25-liv...

Liver and pancreas in metabolic disease: from pathways to therapies

The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

meetings.embo.org

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Yassi Aghazadeh @yassiag.bsky.social · Feb 1

So sorry to hear this 💔💔💔 my heart is with you and him :(

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Reposted by Yassi Aghazadeh

Sara Nunes Vasconcelos, PhD she/her/hers🇨🇦🇧🇷 @saravasconcelos.bsky.social · Jan 29

Amidst the craziness in the world right now I feel there is even more reason to celebrate:
Xuetao's paper is now online! Check it out : www.cell.com/stem-cell-re...
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Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes

In this article, Nunes Vasconcelos and colleagues show that co-delivery of adipose-derived microvessels and hiPSC-cardiomyocytes improves cardiomyocyte survival, graft size, and cardiac function in a ...

www.cell.com

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