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Reposted by Zhiru Liu

Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · Apr 13

My latest in @plosbiology.org Look I get it, it seems really dark, but there are opportunities. My paper explores some ideas and tries to guide ways of thinking through the anticipated challenges. An emphasis on America’s “biohubs” and entrepreneurship

journals.plos.org/plosbiology/...

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NEJM.org @nejm.org · Apr 2

A recent study of an mRNA vaccine in a mouse model of 𝘊𝘭𝘰𝘴𝘵𝘳𝘪𝘥𝘪𝘰𝘪𝘥𝘦𝘴 𝘥𝘪𝘧𝘧𝘪𝘤𝘪𝘭𝘦 infection provided proof of concept of a protective effect. Learn more: nej.md/4kS8x5X

@umich.edu #MedSky #IDSky

An illustration of the candidate vaccine against Clostridioides difficile infection.

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Will Ratcliff @wcratcliff.bsky.social · Mar 20

Here's my interview with @stevenstrogatz.com on @quantamagazine.bsky.social's Joy of Why podcast.

This was *so much fun*. I was nervous going into it (I really look up to Steve!), but I had a blast and I think this is the best interview I have ever done.

Thanks for having me on, folks!

Quanta Magazine @quantamagazine.bsky.social · Mar 20

In the history of evolution, multicellularity has evolved independently at least 50 times. But we’ve only figured that out in the past few decades. Listen to the first episode of the new season of “The Joy of Why” with hosts @stevenstrogatz.com and Janna Levin.
www.quantamagazine.org/how-did-mult...

How Did Multicellular Life Evolve? | Quanta Magazine

One of the most important events in the history of life on Earth was the emergence of multicellularity. In this episode, Will Ratcliff discusses how his snowflake yeast models provide insight into wha...

www.quantamagazine.org

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Doran Goldman @goldmandoran.bsky.social · Mar 11

I’m thrilled to share my first ever publication, now published in PNAS! www.pnas.org/doi/10.1073/...

With mentorship from the amazing @ksxue.bsky.social, I looked at how the outcomes of species introductions to microbial communities are influenced by the number of introduced microbes.

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Jamie Blundell @jamie-blundell.bsky.social · Mar 6

Delighted to share a major update on our work investigating age-related deceleration in clonal haematopoiesis.

Takehome: Widespread and substantial deceleration in fitness with age!

Amazing effort by PhD student Hamish MacGregor 💪

www.biorxiv.org/content/10.1...

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Anastasia Lyulina @alyulina.github.io · Nov 6

I am glad to see this work in print & on the cover! Read more at academic.oup.com/genetics/article/228/3/iyae145/7747749

Artist's depiction of mutant lineages rising and falling in frequency, influenced by selection, recombination, and genetic drift. In this issue, Lyulina et al. develop a mathematical framework for quantifying the statistical associations between these variants. Image courtesy of Anastasia Lyulina.

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Zhiru Liu @zzzhiru.bsky.social · Nov 27

Fascinating work showing genome-wide DNA packaging into phage capsids in "normie" gut bacteria!

colinhillucc.bsky.social @colinhillucc.bsky.social · Nov 26

First post on a lovely story from the lab that shows that Faecalibacterium prausnitzii can package its own genome in bite-size segments in phage-like capsids
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Zhiru Liu @zzzhiru.bsky.social · Nov 27

Really cool and clever study! We saw extensive core genome recombination in gut bacteria in recent work, and I’ve always wondered about the underlying mechanism -- phage-like elements seem like the best candidate. Your examples of LT and GTA are particularly striking.

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Joao Ascensao @joaoascensao.bsky.social · Nov 22

We usually think of genetic drift as the predominant stochastic force in evolving populations. But working with some model microbial populations, we found a distinct source of demographic stochasticity that scales (and behaves) differently than drift

Learn more in our new paper 👉 rdcu.be/d07Np

Asynchronous abundance fluctuations can drive giant genotype frequency fluctuations

Nature Ecology & Evolution - Based on a combination of experiments and modelling, this study shows large stochastic fluctuations in genotype frequencies caused by intrinsic and extrinsic...

rdcu.be

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Katherine Xue @ksxue.bsky.social · Nov 19

Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n

Xue lab at UC Irvine

Ecology and evolution in the human gut microbiome

kxuelab.com

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Aaron Ragsdale @apragsdale.bsky.social · Nov 20

Our paper on allele frequency transitions under polygenic selection, with a focus on evolve & resequence experiments, is up at Genetics. Led by grad student Nathan Anderson:

urldefense.com/v3/__https:/...

A path integral approach for allele frequency dynamics under polygenic selection

Abstract. Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotyp

urldefense.com

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Graham Coop @gcbias.bsky.social · Nov 19

Just posting this to #popgen
Here's a link to my notes on population & quantitative genetics:
github.com/cooplab/popg...
Hoping to extend it more after the winter holidays, as I'm just finishing up teaching the undergrad version of class.

Releases · cooplab/popgen-notes

Population genetics notes. Contribute to cooplab/popgen-notes development by creating an account on GitHub.

github.com

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Inigo Martincorena @imartincorena.bsky.social · Nov 20

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Somatic mutation and selection at epidemiological scale

As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

www.medrxiv.org

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Zhiru Liu @zzzhiru.bsky.social · Apr 23

My first theory project! I've really enjoyed how we could decompose complex dynamics into those of individual lineages.

This approach is quite flexible, and we're hoping to extend it to more complex scenarios, including N(t) and certain forms of positive selection!

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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · Feb 21

High-resolution lineage tracking of within-host evolution and strain transmission in a human gut symbiont across ecological scales https://www.biorxiv.org/content/10.1101/2024.02.17.580834v1

Gut bacteria rapidly evolve in vivo, but their long-term success requires dispersal across hosts. He

www.biorxiv.org

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Zhiru Liu @zzzhiru.bsky.social · Feb 24

Thanks for the kind words☺️

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