AGAlattar
@agalattar.bsky.social
Abdul Ghani Alattar, M.D., Ph.D.
Postdoctoral Researcher
Department of Medicine | Karolinska Institutet Center for Hematology and Regenerative Medicine
Postdoctoral Researcher
Department of Medicine | Karolinska Institutet Center for Hematology and Regenerative Medicine
Reposted by AGAlattar
⚡Our November issue is out! Featuring trials of #CARTcells for #LUPUS, an #ADC for #lungcancer, cardiac #genetherapy, an #ebola #vaccine, discovery of microbial elements in #braintumors, #liquidbiopsies, #newbornscreening, News, Reviews, & more.
https://www.nature.com/nm/volumes/31/issues/11
https://www.nature.com/nm/volumes/31/issues/11
November 19, 2025 at 4:33 PM
⚡Our November issue is out! Featuring trials of #CARTcells for #LUPUS, an #ADC for #lungcancer, cardiac #genetherapy, an #ebola #vaccine, discovery of microbial elements in #braintumors, #liquidbiopsies, #newbornscreening, News, Reviews, & more.
https://www.nature.com/nm/volumes/31/issues/11
https://www.nature.com/nm/volumes/31/issues/11
Reposted by AGAlattar
🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture.
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
November 27, 2025 at 4:53 PM
🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture.
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Reposted by AGAlattar
St. Jude scientists discovered mitoxyperilysis, a new cell death pathway triggered by inflammation and nutrient stress. This finding opens new possibilities for cancer therapies targeting damaged mitochondria and inflammatory cell death. ow.ly/wf9S50Xz8P0
Inflammation and metabolic stress combine to drive a new cell death pathway: mitoxyperilysis
Discover how St. Jude research uncovered an unknown cell death pathway triggered by innate immune activation and nutrient scarcity that may help treat cancer.
ow.ly
November 28, 2025 at 5:15 PM
St. Jude scientists discovered mitoxyperilysis, a new cell death pathway triggered by inflammation and nutrient stress. This finding opens new possibilities for cancer therapies targeting damaged mitochondria and inflammatory cell death. ow.ly/wf9S50Xz8P0
Reposted by AGAlattar
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/4oNJSAG
go.nature.com/4oNJSAG
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
go.nature.com
October 30, 2025 at 9:13 AM
Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale
go.nature.com/4oNJSAG
go.nature.com/4oNJSAG
Reposted by AGAlattar
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
November 18, 2025 at 5:49 PM
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
Reposted by AGAlattar
Skoda and Silvennoinen highlight new work from Zhou et al. (rupress.org/jem/article/...) describing the different effects of heterozygous and homozygous JAK2V617F mutations on hematopoietic progenitors rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 11, 2025 at 5:00 PM
Skoda and Silvennoinen highlight new work from Zhou et al. (rupress.org/jem/article/...) describing the different effects of heterozygous and homozygous JAK2V617F mutations on hematopoietic progenitors rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Reposted by AGAlattar
Scientists at St. Jude and Northwestern University have uncovered how CRISPR-Cas9 gene therapy silences BCL11A in sickle cell disease and β-thalassemia. The therapy disrupts a 3D genome structure essential for BCL11A expression, reactivating fetal hemoglobin. ow.ly/to6w50XpI9H
Gene therapy for sickle cell and β-thalassemia works by disrupting three-dimensional genome structure
See how scientists identified a previously unknown treatment opportunity for sickle cell disease and β-thalassemia based on how CRISPR-based gene therapy works
ow.ly
November 10, 2025 at 10:06 PM
Scientists at St. Jude and Northwestern University have uncovered how CRISPR-Cas9 gene therapy silences BCL11A in sickle cell disease and β-thalassemia. The therapy disrupts a 3D genome structure essential for BCL11A expression, reactivating fetal hemoglobin. ow.ly/to6w50XpI9H
Reposted by AGAlattar
St. Jude scientists have launched AlphaSync, a continuously updated database of predicted protein structures. AlphaSync bridges the gap left by previous resources, ensuring researchers access the most current models. ow.ly/UpUc50Xq7t7
AlphaSync database keeps protein structure prediction resource up to date
Discover how St. Jude scientists created AlphaSync, a database that keeps protein predictions up to date to push science forward & prevents cascading errors.
ow.ly
November 11, 2025 at 6:00 PM
St. Jude scientists have launched AlphaSync, a continuously updated database of predicted protein structures. AlphaSync bridges the gap left by previous resources, ensuring researchers access the most current models. ow.ly/UpUc50Xq7t7
Reposted by AGAlattar
The marrow and blood showed distinct patterns of IR after transplant with differences in lymphocyte subsets and phenotypes. buff.ly/91m7gC4 #hemesky
November 6, 2025 at 4:30 PM
The marrow and blood showed distinct patterns of IR after transplant with differences in lymphocyte subsets and phenotypes. buff.ly/91m7gC4 #hemesky
Reposted by AGAlattar
🩸120M units of blood are donated each year, yet demand exceeds supply. Prof Martin Olsson's research at @lundstem.bsky.social aims to make transfusions safer & universal. He received the AABB President’s Award for his contributions to #TransfusionMedicine 👏
www.stemcellcenter.lu.se/article/mart...
www.stemcellcenter.lu.se/article/mart...
Martin L Olsson receives the AABB President's Award for advancing blood transfusion medicine and safety
Lund University. At the AABB General Meeting award ceremony in San Diego on October 25, 2025, Martin L. Olsson was honored as one of this year’s recipients of the AABB President’s Award. He was recogn...
www.stemcellcenter.lu.se
November 3, 2025 at 1:54 PM
🩸120M units of blood are donated each year, yet demand exceeds supply. Prof Martin Olsson's research at @lundstem.bsky.social aims to make transfusions safer & universal. He received the AABB President’s Award for his contributions to #TransfusionMedicine 👏
www.stemcellcenter.lu.se/article/mart...
www.stemcellcenter.lu.se/article/mart...
Reposted by AGAlattar
Heterozygous human JAK2V617F activates AhR to drive essential #thrombocythemia and promote #thrombosis, say Li Zhou, Dongxiao Wu, Xiaohui Zhang, Bo Huang and colleagues: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
October 22, 2025 at 6:45 PM
Heterozygous human JAK2V617F activates AhR to drive essential #thrombocythemia and promote #thrombosis, say Li Zhou, Dongxiao Wu, Xiaohui Zhang, Bo Huang and colleagues: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Reposted by AGAlattar
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
October 6, 2025 at 9:42 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
Reposted by AGAlattar
Why does leukemia develop so early in life?
In a new study in Leukemia, researchers in @boierslab.bsky.social found a new precursor stage of leukemia during fetal blood development, offering clues to how infant #leukemia begins. #CancerResearch
📖 Read more:
www.stemcellcenter.lu.se/article/rese...
In a new study in Leukemia, researchers in @boierslab.bsky.social found a new precursor stage of leukemia during fetal blood development, offering clues to how infant #leukemia begins. #CancerResearch
📖 Read more:
www.stemcellcenter.lu.se/article/rese...
Researchers find new clues as to why leukemia develops in infants
Lund University. When we think of cancer, we usually imagine a disease that develops over many years in adults. But for one particular group of leukemia – acute lymphoblastic leukemia (ALL) – it is qu...
www.stemcellcenter.lu.se
October 28, 2025 at 1:27 PM
Why does leukemia develop so early in life?
In a new study in Leukemia, researchers in @boierslab.bsky.social found a new precursor stage of leukemia during fetal blood development, offering clues to how infant #leukemia begins. #CancerResearch
📖 Read more:
www.stemcellcenter.lu.se/article/rese...
In a new study in Leukemia, researchers in @boierslab.bsky.social found a new precursor stage of leukemia during fetal blood development, offering clues to how infant #leukemia begins. #CancerResearch
📖 Read more:
www.stemcellcenter.lu.se/article/rese...
Reposted by AGAlattar
🩸 Only one person in the world is known to have the rarest blood group - Gwada-negative.
In @theconversationuk.bsky.social, Lund Stem Cell Center researchers Martin Olsson & Jill Storry explain how it was discovered and why it matters for safe transfusions.
👉 theconversation.com/gwada-negati...
In @theconversationuk.bsky.social, Lund Stem Cell Center researchers Martin Olsson & Jill Storry explain how it was discovered and why it matters for safe transfusions.
👉 theconversation.com/gwada-negati...
Gwada-negative: the rarest blood group on Earth
Scientists find 48th blood group in woman with no compatible donors.
theconversation.com
October 10, 2025 at 1:08 PM
🩸 Only one person in the world is known to have the rarest blood group - Gwada-negative.
In @theconversationuk.bsky.social, Lund Stem Cell Center researchers Martin Olsson & Jill Storry explain how it was discovered and why it matters for safe transfusions.
👉 theconversation.com/gwada-negati...
In @theconversationuk.bsky.social, Lund Stem Cell Center researchers Martin Olsson & Jill Storry explain how it was discovered and why it matters for safe transfusions.
👉 theconversation.com/gwada-negati...