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Antoni Wrobel

@agwrobel.bsky.social

550 followers 810 following 24 posts

Structural biologist and group leader at the Oxford Biochemistry Department. Interested in principles and molecular mechanisms underlying viral evolution and host changes.

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Reposted by Antoni Wrobel

Gene Chong @chongg.bsky.social · 12d

Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem

www.nature.com/articles/s41...

Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology

Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

Antoni Wrobel @agwrobel.bsky.social · 12d

Great stuff!

Ulad Litvin @ulad-litvin.bsky.social · 12d

Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵

📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology

imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

Reposted by Antoni Wrobel

Marcin J. Suskiewicz @msuskiewicz.bsky.social · 22d

Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Dear scientific community,

I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.

my.corehr.com/pls/uoxrecru...

my.corehr.com/pls/uoxrecru...

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Full details about the posts, responsibilities, and selection criteria are available through the links above. The deadline for applications is 22 September 2025. Please feel free to email "antoni.wrobel at bioch.ox.ac.uk" with informal enquiries.

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Second project is an HFSP-funded collaboration with the Suskiewicz group in Orléans, France (including an extended scientific visit to their lab). It tackles the functional importance and prevalence of filamentation among transcription factors to better understand the principles of gene expression.

Antoni Wrobel @agwrobel.bsky.social · Sep 8

First project is funded by the Wellcome and investigates how receptor selection may influence the mechanism of viral entry. Understanding this will help us better understand past pandemics and prepare more effectively for those in the future.

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Our small research team uses structural methods, biophysics, and cell biology to investigate the molecular mechanisms underlying viral evolution and host adaptation. More details of our work can be found here: wrobel-lab.org

Wrobel lab | Explore Mechanisms of Viral Infection studied at Oxford Biochemistry Department

Discover our research on viral evolution and host interactions. Join our team and stay updated with the latest lab news and publications.

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Dear scientific community,

I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.

my.corehr.com/pls/uoxrecru...

my.corehr.com/pls/uoxrecru...

Antoni Wrobel @agwrobel.bsky.social · Jul 22

This great paper from Bing Chen's lab has revealed where it is: www.nature.com/articles/s41...

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane - Nature

The SARS-CoV-2 spike internal fusion peptide forms a hairpin-like wedge that spans almost the entire lipid bilayer and the transmembrane segment wraps around the fusion peptide at the last stage of me...

Reposted by Antoni Wrobel

Alexey Amunts @amunts.bsky.social · Jun 23

Running Phenix and stuck?
Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program.
Big thanks to Tom Willinger for making this happen!
Try it out: phenix-online.org/version_docs...

Reposted by Antoni Wrobel

ilesla.bsky.social @ilesla.bsky.social · May 19

Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...

RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences

iles.web.ox.ac.uk

Reposted by Antoni Wrobel

Phil Biggin @philbiggin.bsky.social · May 7

Congratulations! @jansenlab.bsky.social
@oxfordbiochemistry.bsky.social

www.nature.com/articles/s41...

Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling - Nature Structural & Molecular Biology

Mikulski et al. identify a distinct chromatin structure at clustered GBP innate immune genes that preserves a mitotically heritable memory of prior priming by interferon-γ.

Antoni Wrobel @agwrobel.bsky.social · May 6

That's definitely not the case here!

Antoni Wrobel @agwrobel.bsky.social · May 6

As for some networks - e.g. Eduroam - new domains seem to get blocked, here's the alternative address of the lab website: tinyurl.com/wrobel-lab

Wrobel lab | Explore Mechanisms of Viral Infection studied at Oxford Biochemistry Department

Discover our research on viral evolution and host interactions. Join our team and stay updated with the latest lab news and publications.

Antoni Wrobel @agwrobel.bsky.social · May 6

Answering these questions will help us understand some past pandemics and better prepare for those in future.

tinyurl.com/postdoc-wrob... contains the details but please do not hesitate to contact me directly via email antoni.wrobel at bioch.ox.ac.uk with informal enquiries.

Antoni Wrobel @agwrobel.bsky.social · May 6

Our team investigates molecular mechanisms underlying viral evolution and host changes. Your project will focus on understanding how some viruses can change their receptor specificity from glycan- to protein-binding and how the receptor selection may influence viral entry.

Antoni Wrobel @agwrobel.bsky.social · May 6

We are currently seeking an ambitious, motivated, and hard-working scientist to join my lab (wrobel-lab.org) at the Department of Biochemistry of the University of Oxford as a Postdoctoral Research Associate. If interested, please go here directly: tinyurl.com/postdoc-wrob... or read more below.

Wrobel lab | Explore Mechanisms of Viral Infection studied at Oxford Biochemistry Department

Discover our research on viral evolution and host interactions. Join our team and stay updated with the latest lab news and publications.

Antoni Wrobel @agwrobel.bsky.social · Apr 3

Thanks Elias!

Antoni Wrobel @agwrobel.bsky.social · Apr 1

Congrats @msuskiewicz.bsky.social and @mvstaller.bsky.social ! And thanks for all your work and inviting me to contribute - looking very much forward to working together!

Marcin J. Suskiewicz @msuskiewicz.bsky.social · Mar 28

I'm happy (if somewhat uneasy, given the times are uncertain for many) to have been selected for an @hfspo.bsky.social HFSP Research Grant Early Career, with great partners: @mvstaller.bsky.social & @agwrobel.bsky.social . We will study filament formation by transcription factors.

Reposted by Antoni Wrobel

Ben Engel @cellarchlab.com · Mar 20

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

Antoni Wrobel @agwrobel.bsky.social · Jan 17

An amazing new fully-funded DPhil/PhD opportunity at Oxford and beyond: with great learning opportunities and a lot of supervisors from various disciplines (including myself). Please apply and share with those potentially interested!

ilesla.bsky.social @ilesla.bsky.social · Jan 16

Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.

How to Apply and Funding

iles.web.ox.ac.uk

Reposted by Antoni Wrobel

Melina Vallbracht @vallbracht.bsky.social · Jan 7

We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!

Antoni Wrobel @agwrobel.bsky.social · Jan 9

That's amazing, massive congrats Melina et al!

Reposted by Antoni Wrobel

Mart Krupovic @mkrupovic.bsky.social · Dec 23

Check out the magnificent #baculovirus structure! The unique virion architecture and structural atlas of hallmark proteins place baculo-like viruses into a separate new realm. Many insights into baculo biology and evolution. Collab with the group of Fasséli Coulibaly. www.science.org/doi/10.1126/...

Reposted by Antoni Wrobel

Mart Krupovic @mkrupovic.bsky.social · Dec 30

RNA virologists, check out "The protein structurome of Orthornavirae and its dark matter" by Pascal Mutz, Valerian Dolja, Eugene Koonin et al (including @simrouxvirus.bsky.social, @apcamargo.bsky.social, @urineri.bsky.social, @anamarijabutkovic.bsky.social)
journals.asm.org/doi/10.1128/...

The protein structurome of Orthornavirae and its dark matter | mBio

Advanced methods for protein structure prediction, such as AlphaFold2, greatly expand our capability to identify protein domains and infer their likely functions and evolutionary relationships. This i...

journals.asm.org