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Reposted by Lauren Albrecht

Perrimon Lab @perrimonlab.bsky.social · Aug 12

Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth
Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon
bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...

Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth

Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its tiss...

doi.org

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Lauren Albrecht @albrechtlab.bsky.social · Jun 6

pharmsci.uci.edu/2025/06/05/a...

Albrecht Lab Hosted Lab Visit for Children with Cystinosis as Part of Cystinosis Research Foundation’s Day of Hope Family Conference – UCI School of Pharmacy & Pharmaceutical Sciences

pharmsci.uci.edu

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Reposted by Lauren Albrecht

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Apr 9

🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY

The guinea pig serves as an alternative model to study human preimplantation development - Nature Cell Biology

Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.

bit.ly

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Reposted by Lauren Albrecht

Aakriti Jain @aakritijain.bsky.social · Mar 27

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org

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Reposted by Lauren Albrecht

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jan 22

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.

www.science.org

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Lauren Albrecht @albrechtlab.bsky.social · Feb 26

Lipidome, proteome, LSD. What’s not to love??

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Feb 25

In a new publication from CRN Team Harper found that select LSDs can cause problems with mitochondria. Specifically, these LSDs can interfere with the recycling of iron, which is important for mitochondria to function properly 🔬

🔗 Check out the full #publication: shorturl.at/HTPqW

Multilamellar membranes in NPC2−/− lysosomes visualized by cryo-ET.

Reposted by Lauren Albrecht

Rajat Singh Lab @lipophagy.bsky.social · Jan 5

Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....

Identification of the mammalian VPS4A as a selective lipophagy receptor

www.tandfonline.com

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Lauren Albrecht @albrechtlab.bsky.social · Feb 25

So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd

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Lauren Albrecht @albrechtlab.bsky.social · Feb 21

Thank you Brian !!

Brian Paegel @briandna.bsky.social · Feb 20

Congrats to my colleague, Prof. Albrecht @albrechtlab.bsky.social , who is a new Sloan Fellow! news.uci.edu/2025/02/20/u...

UC Irvine assistant professor Lauren Albrecht named 2025 Sloan Foundation Research Fellow

Accomplished early-career pharmaceutical scientist recognized as next-generation leader

news.uci.edu

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Lauren Albrecht @albrechtlab.bsky.social · Feb 18

Honored to be a 2025 Sloan Research Fellow! #sloanfellow

Alfred P. Sloan Foundation @sloanfoundation.bsky.social · Feb 18

🎉Congrats to the 126 early-career scientists who have been awarded a Sloan Research Fellowship this year! These exceptional scholars are drawn from 51 institutions across the US and Canada, and represent the next generation of groundbreaking researchers. sloan.org/fellowships/...

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Reposted by Lauren Albrecht

Brian Paegel @briandna.bsky.social · Feb 5

Pondering a purge of pesky pathological proteins?

Lauren Albrecht @albrechtlab.bsky.social · Feb 5

Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC �Š @danafarber.bsky.social

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Reposted by Lauren Albrecht

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 4

Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF

www.nature.com/articles/s41...

The role of ionic blockades in controlling the efficiency of energy recovery in forward bias bipolar membranes - Nature Energy

Bipolar membranes are increasingly being applied in a variety of electrochemical devices, yet understanding of how they operate in complex electrolyte environments is still limited. Here the authors o...

www.nature.com

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Lauren Albrecht @albrechtlab.bsky.social · Feb 5

Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC �Š @danafarber.bsky.social

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Reposted by Lauren Albrecht

Brian Kleiboeker @bkleiboeker.bsky.social · Dec 20

CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint!

www.biorxiv.org/content/bior...

www.biorxiv.org

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Reposted by Lauren Albrecht

Cell Biology J-Club @cellclub.bsky.social · Jan 26

Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction www.biorxiv.org/content/10.1...

Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction

Peroxisomes carry out a diverse set of metabolic functions, including oxidation of very long-chained fatty acids, degradation of D-amino acids and hydrogen peroxide, and bile acid production. Many of ...

www.biorxiv.org

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Reposted by Lauren Albrecht

Guillaume Méric @gmeric.bsky.social · Oct 28

"An early-life microbiota metabolite [peroxisome proliferator-activated receptor γ, or PPAR-γ] protects against obesity by regulating intestinal lipid metabolism [in mice]"
www.sciencedirect.com/science/arti...

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Reposted by Lauren Albrecht

Nature Chemical Biology @natchembio.nature.com · Dec 19

... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins - Nature Chemical Biology

Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins in lysosomes.

doi.org

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Reposted by Lauren Albrecht

Nature Chemical Biology @natchembio.nature.com · Dec 19

Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover.
www.nature.com/nchembio/vol...

Image shows a confocal microscopy image of methylated proteins in gold in HeLa cells organizing into cytosolic puncta with a nuclear costain shown in blue.

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Reposted by Lauren Albrecht

Thomas Arnesen @natmachinery.bsky.social · Dec 4

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...

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Reposted by Lauren Albrecht

Craig M. Crews @craigmcrews.bsky.social · Oct 12

www.nature.com/articles/d41...

PROTAC protein degraders to drug the undruggable enter phase 3 trials

Pharmaceutical companies are investing in therapies that target proteins for degradation, with trials ongoing for cancer, autoimmune diseases and neurological disorders.

www.nature.com

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Lauren Albrecht @albrechtlab.bsky.social · Dec 16

Loving #CellBio2024 and excited to present in micro session MONDAY 10:30 AM 28C microsession #MrTAC #lysosome #degrader #TPD #methylation

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Lauren Albrecht @albrechtlab.bsky.social · Dec 9

Excited to attend ASCB #CellBio2024! The Albrecht lab will present on lysosomes, quality control, lipid / carbohydrate metabolism, and MrTAC TPD targeted degrader.
Please check out our lab's talks and posters:

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Reposted by Lauren Albrecht

Science Magazine @science.org · Dec 6

A new #ScienceAdvances study demonstrates a vaccine for cancer immunotherapy that would speed up the efficiency of messenger RNA translation in cytoplasm—and effectively inhibited tumor growth. scim.ag/49qY0sY

mRNA compartmentalization via multimodule DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine

Intracellular DNA assembly for mRNA vaccine compartmentalization facilitates antigen expression and enhances adjuvant efficacy.

scim.ag

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Lauren Albrecht @albrechtlab.bsky.social · Dec 7

Dream come true to be featured on the cover!

Thomas Arnesen @natmachinery.bsky.social · Dec 4

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...

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Lauren Albrecht @albrechtlab.bsky.social · Dec 2

Happy to see you here so that I can know all the best people I should be following by just looking at whatever you have posted!! Doing all the hard work for me!!

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