Eric Thompson, Ph.D.
@azbiomarkers.bsky.social
270 followers 160 following 230 posts
Precision medicine translational pharmacologist and cancer biologist, utilizing evidence based medicine to move biomarkers into the clinic. Views are my own.
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Reposted by Eric Thompson, Ph.D.
nmoris.bsky.social
The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍
crick.ac.uk
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...
azbiomarkers.bsky.social
Apologies - the decision support interpretation isn’t quite there outside of these Rx ( e.g. DPYD for fluoropyrimidines).
azbiomarkers.bsky.social
There are a couple of instances in cancer Rx when it is crucial, but the decision support interpretation isn’t quite there. I have these conversations all the time - en route to some now. Polite is all we can ask. We have to bring the science.
azbiomarkers.bsky.social
Think I saw a recent announcement of a company re-entering this space. Have not checked their science.
azbiomarkers.bsky.social
There is not enough data spanning the entire ADME enzymatic system to integrate findings into clinical decisions. There is not a monetary incentive to create these data. Until this is solved you are correct. The data existing often are not used (e.g. warfarin, irinoteca).
Reposted by Eric Thompson, Ph.D.
scinews.bsky.social
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
Reposted by Eric Thompson, Ph.D.
nature.com
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
Reposted by Eric Thompson, Ph.D.
natrevdrugdiscov.nature.com
Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells www.nobelprize.org/prizes/medic...

For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review www.nature.com/articles/s41...
rdcu.be/eJHU8
Regulatory T cell biology
Reposted by Eric Thompson, Ph.D.
c0nc0rdance.bsky.social
You're watching 12 hrs of live cell imaging compressed into a GIF.

A multi-nucleated mouse pre-adipocyte tries to undergo mitosis, triggers a checkpoint because it has too much DNA, & undergoes apoptosis.

The last stage is called "blebbing", which is wonderfully descriptive.

(🔬: NanoLive Imaging)
Reposted by Eric Thompson, Ph.D.
acochran12733.bsky.social
jco-asco.bsky.social
We're thrilled to be here on BlueSky to bring you the latest practice-changing oncology research from all six JCO Journals! Follow-us for great content from #JCO, #JCOOP, #JCOGO, #JCOPO, #JCOCCI, & #JCOOA.
Reposted by Eric Thompson, Ph.D.
natbiotech.nature.com
In Brief: @novonordisk.bsky.social's #Wegovy gains accelerated FDA approval for treating metabolic dysfunction-associated steatohepatitis (MASH), also known as fatty liver disease www.nature.com/articles/s41...
rdcu.be/eHgPo
Wegovy approved for MASH - Nature Biotechnology
Nature Biotechnology - Wegovy approved for MASH
www.nature.com
azbiomarkers.bsky.social
Unless GINA is strengthened to include many more insurance utility cases this data will be sought by underwriters. It is their business model to accurately model risk, and these data can be a help for them. The harm to the subject is actually a win in this business setting. We need to expand GINA.
Reposted by Eric Thompson, Ph.D.
labwaggoner.bsky.social
Molecular subtypes of human skeletal muscle in cancer cachexia @nature.com
nature.com/articles/s41...
azbiomarkers.bsky.social
The juxtaposition was remarkable. Perseverance is the key attribute in science.
Reposted by Eric Thompson, Ph.D.
compoundchem.com
As summer fades, dahlias are blooming. This graphic looks at the chemical cause of their colours and why you won't spot a blue one! www.compoundchem.com/2021/09/12/d...
#ChemSky 🧪
Infographic on the chemistry of dahlia flower colours. The colours of dahlias are a result of anthocyanin-, chalcone- and aurone-derived pigments. Colourless sflavones also interact with and stabilise anthocyanin pigments. Chalcones and aurones lead to yellow and orange dahlias, while anthocyanins play a part in orange, pink, red and black dahlias. Blue dahlias aren't seen because dahlias lack an enzyme for making delphinidin, the anthocyanin which leads to blue flowers.
Reposted by Eric Thompson, Ph.D.
obenaufa.bsky.social
Anyone working in metastasis research – the BEUG Foundation has once again opened the call for their Metastasis Research Prize.
This prize is a wonderful recognition of innovative contributions and supports excellence in metastasis research across Europe.
www.beugstiftung-metastase.de/apply-now/
Apply now – Beugstiftung
www.beugstiftung-metastase.de
azbiomarkers.bsky.social
I wonder how many tons of Coccidioidomycosis (Valley Fever)spores got distributed in that. Is there any indication of a spike in cases after a haboob?
azbiomarkers.bsky.social
I’d second that - tenacity is the key. Many don’t have the stamina to follow through on a problem for years. The tenacity to make it through the negative results is key.
Reposted by Eric Thompson, Ph.D.
richardsever.bsky.social
"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?

One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com