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NIHR Oxford BRC @oxfordbrc.bsky.social · 3d

Why are more younger adults having strokes? Come along to our next free public talk on Tues 4 Nov 6pm to hear researcher Linxin Li discuss what is driving the recent increase and how we tackle it oxfordbrc.nihr.ac.uk/brc-event/fr... @ouhospitals.bsky.social
@medsci.ox.ac.uk
@ndcnoxford.bsky.social

FREE Public Talk – Why are more younger people having strokes? | NIHR Oxford Biomedical Research Centre

oxfordbrc.nihr.ac.uk

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Simon Buczacki @sibucz.bsky.social · 3d

New CRUK Post-doc position in our group. #mutationalorder #multiomics #cancer.
my.corehr.com/pls/uoxrecru...

Job Details

my.corehr.com

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fairfaxlab @bpfairfax.bsky.social · 3d

Interesting paper from Becki Lee and colleagues:

www.biorxiv.org/content/10.1...

Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases

Here, we investigate why liver metastases reduce the efficacy of immune checkpoint inhibitors (CPI). The poor prognosis of patients with liver metastases is associated with a systemic increase in neut...

www.biorxiv.org

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University of Oxford Department of Oncology @oncology.ox.ac.uk · 6d

New findings in @natcomms.nature.com demonstrate the impact of allelic variation on monocyte context-specific splicing.

@bpfairfax.bsky.social & colleagues show that many risk polymorphisms lead to differential gene splicing.

➡️Reveals putative mechanisms of diverse disease risk alleles inc. cancer

Genetic determinants of monocyte splicing are enriched for disease susceptibility loci - Nature Communications

Our understanding of variation in monocyte context-specific splicing and transcript usage is limited. Here, the authors find genetic variants that affect gene splicing in monocytes in specific contexts, including several diseases, and in response to stimulants.

www.nature.com

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Julius Brennecke @juliusbrennecke.bsky.social · 22d

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.

But how does piRNA-guided target interaction translate into silencing?

PhD student Júlia Portell Montserrat has an intriguing answer

www.cell.com/molecular-ce...

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fairfaxlab @bpfairfax.bsky.social · Sep 3

Great news Simon!

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Yang Luo @y-luo.bsky.social · Jul 28

📣First paper from the lab is out in @science.org‬! 📣https://www.science.org/doi/10.1126/sciadv.adu3461 It’s well known that HLA shapes the TCR repertoire — but how does this change under immune checkpoint blockade (ICB)?

Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade

Immune checkpoint blockade influences the genetically determined relationship between TCR repertoire and HLA alleles in cancer.

www.science.org

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Evgeny Kvon @evgenykvon.bsky.social · Jul 2

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Range extender mediates long-distance enhancer activity - Nature

The REX element is associated with long-range enhancer–promoter interactions.

www.nature.com

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Nick Kapur @nickkapur.bsky.social · Jul 2

It's hard to avoid recalling this passage from the English historian Tony Judt:

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Eric Topol @erictopol.bsky.social · Jul 2

"The diminution and marginalization of science are thus central parts of the erosion of democracy itself."
www.science.org/doi/10.1126/...

Will we habituate to the decline of democracy?

The recent attack on science in the US is not only undermining knowledge; it is also undermining democracy. In a healthy democracy, public policy is guided by evidence, and truth is the shared foundat...

www.science.org

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max tani @maxtani.bsky.social · Jun 25

amazing q&a with paul krugman

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Petter Brodin @petterbrodin.bsky.social · Jun 25

No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university

Evaluating IL1RA‐Autoantibodies Across SARS‐CoV‐2‐Related Diseases

Click on the article title to read more.

onlinelibrary.wiley.com

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The Washington Post @washingtonpost.com · Jun 16

Black people who are diagnosed with melanoma are about five times as likely as White people to die within five years.

Find out how and where to look for the disease.

Too often, Black patients get late diagnoses of deadly skin cancer

For Black people, surviving skin cancer begins with knowing what to look for — and where to look.

www.washingtonpost.com

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Mike Inouye @mikeinouye.bsky.social · Jun 16

Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task arxiv.org/abs/2506.08872

h\t @gmeric.bsky.social

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Simon Richardson @simonrichardson.bsky.social · May 20

Delighted that our work describing a potential novel treatment approach for B-cell Acute Lymphoblastic Leukaemia is published today in @natcomms.nature.com‬. 🧵

www.nature.com/articles/s41...

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition - Nature Communications

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

www.nature.com

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Pradeep Natarajan @pnatarajanmd.bsky.social · Apr 23

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

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Vijay G. Sankaran @bloodgenes.bsky.social · Jun 4

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...

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fairfaxlab @bpfairfax.bsky.social · May 8

The worst thing is the wellness snake oil brigade preying on those with illnesses such as cancer.

Patients asking about detoxing livers, altering microbiomes, getting bicarb infusions and having coffee enemas. None of it based on any evidence except the ability to make money from the sick.

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Mike Inouye @mikeinouye.bsky.social · May 7

📣📣 Thrilled to see this cool work finally out in the wild! "Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology & prediction" www.nature.com/articles/s41...

Loads of cool findings including MR for alcohol usage -> increased variance in BC traits

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Ben Goldacre @bengoldacre.bsky.social · May 7

The amount of single use plastic passing through my house is insane. It's mostly food. I don't know how we all got used to this, and fighting it alone seems pointless. We fritter the years away, in politics world, on just getting by. I'd love to see big energetic policy moves to fix big things well.

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Willem van Schaik @wvschaik.bsky.social · May 6

'Of course Britain could restrict international student numbers. We could halve the number, and make ourselves £10bn poorer every year, concentrated in Labour held seats.'

timleunig.substack.com/p/internatio...

International university students

Let’s not shoot ourselves in the foot again.

timleunig.substack.com

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Simon Fisher @profsimonfisher.bsky.social · May 2

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

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Simon Fisher @profsimonfisher.bsky.social · May 2

I could go on with more examples but instead here’s a message to take home. If you’re curious how your genome helps make you unique, don’t expect neat & tidy answers. Indeed, the richness of this tapestry is one of the reasons why human genetics is such a dynamic & exciting field of science. 11/n 🧬🧪

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Ulrike Harjes @ulrikeharjes.bsky.social · May 5

To celebrate our 30th anniversary, Nature Medicine has commissioned 'Turning points' articles, in which researchers discuss the impact of their scientific discovery that was published around 30 yrs ago. Read this one: PD-L1 and the dawn of modern cancer immunotherapy www.nature.com/articles/s41...

PD-L1 and the dawn of modern cancer immunotherapy - Nature Medicine

Lieping Chen describes how his discoveries with PD-L1 yielded life-saving treatments for several cancers.

www.nature.com

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Dr. Glaucomflecken @glaucomflecken.bsky.social · May 5

Just passing along some friendly advice on how to approach potential changes to the Australian health care system @drruthmitchell.bsky.social

PowerPoint slide that says: “does America do it, if yes, then no”

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