Geming Lu
@brian98er.bsky.social
Immunologist and islets biologist, dedicated to the autoimmune and Metabolism research of T1D, T2D, colitis, and multiple sclerosis.
A metabolic atlas of mouse aging: Cell Metabolism www.cell.com/cell-metabol...
A metabolic atlas of mouse aging
Pilley et al. describe how metabolite levels change in 12 organs from male and female
mice across five ages, spanning adolescence to old age. They reveal that organs show
distinct age- and sex-specifi...
www.cell.com
November 27, 2025 at 7:17 PM
A metabolic atlas of mouse aging: Cell Metabolism www.cell.com/cell-metabol...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 13, 2025 at 4:39 AM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes - Nature Communications
PROTACs induce degradation by bridging a target protein and E3 ubiquitin ligase. Here, authors show that protein interface frustration correlates with cooperativity, offering a structural metric to prioritize PROTAC candidates prior to synthesis.
www.nature.com
October 9, 2025 at 3:22 AM
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene - Nature Communications
β-cell dysfunction and dedifferentiation towards an α-cell-like phenotype are hallmarks of type 2 diabetes. Her,e the authors detect five α-cell subpopulations, find differences between healthy and diabetic donors, and identify SMOC1 as an inducer of human β-cell dysfunction and dedifferentiation.
www.nature.com
October 8, 2025 at 2:44 AM
Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
JCI - Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes www.jci.org/articles/vie...
JCI -
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
www.jci.org
October 4, 2025 at 4:13 AM
JCI - Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes www.jci.org/articles/vie...
A vascular-associated fibroblastic cell controls pancreatic islet immunity.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
A vascular-associated fibroblastic cell controls pancreatic islet immunity
Clarke et al. reveal that non-hematopoietic cells, fibroblastic in nature, located
outside the islet of Langerhans, spontaneously present β cell antigens. These cells,
associated with the post-capilla...
www.cell.com
September 3, 2025 at 5:07 AM
A vascular-associated fibroblastic cell controls pancreatic islet immunity.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Improving cellular fitness of human stem cell-derived islets under hypoxia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Improving cellular fitness of human stem cell-derived islets under hypoxia - Nature Communications
Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...
www.nature.com
May 28, 2025 at 4:42 PM
Improving cellular fitness of human stem cell-derived islets under hypoxia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses
Pregnancy is associated with physiological adaptations that affect virtually all organs,
enabling the mother to support the growing fetus and placenta while withstanding the
demands of pregnancy. As a...
www.cell.com
May 26, 2025 at 5:35 AM
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
T and B cells cooperate in meningeal eLFs to promote differentiation and clonal expansion of B cells and reactivation of CNS T cells.
www.science.org
May 1, 2025 at 6:37 AM
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation - Nature Communications
Xenotransplantation is a promising option when allogeneic donors are unavailable but hampered by a more stringent immunological barrier. Here authors show that hypoimmune cells engineered to overcome ...
www.nature.com
April 29, 2025 at 3:33 PM
Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen,
Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring
T1D. Their creative and r...
www.cell.com
April 26, 2025 at 1:43 AM
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/...
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat un...
www.science.org
April 24, 2025 at 9:25 PM
Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/...
Reposted by Geming Lu
#SkeletalMuscle #Mitophagy #ERPhagy
ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy
@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....
ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy
@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....
April 1, 2025 at 7:42 PM
#SkeletalMuscle #Mitophagy #ERPhagy
ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy
@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....
ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy
@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation
The sequential order of NGN3 and NEUROD1 expression shapes their pioneer functions in pancreatic endocrine differentiation.
www.science.org
March 28, 2025 at 4:48 AM
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation
The sequential order of NGN3 and NEUROD1 expression shapes their pioneer functions in pancreatic endocrine differentiation.
www.science.org
March 28, 2025 at 2:47 AM
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...
Reposted by Geming Lu
Excited to share our work in @naturecomms.bsky.social
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications
Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
www.nature.com
March 2, 2025 at 12:03 PM
Excited to share our work in @naturecomms.bsky.social
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes - Nature Communications
The pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell RNA...
www.nature.com
March 1, 2025 at 6:46 PM
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Geming Lu
Characterization of islet cells from people with type 1 #diabetes underscores the complex interplay between immune signaling, metabolic stress, and cellular identity in shaping islet cell phenotypes in #T1D @bcellorg.bsky.social www.biorxiv.org/content/10.1... @albertadiabetes.bsky.social
February 24, 2025 at 2:16 AM
Characterization of islet cells from people with type 1 #diabetes underscores the complex interplay between immune signaling, metabolic stress, and cellular identity in shaping islet cell phenotypes in #T1D @bcellorg.bsky.social www.biorxiv.org/content/10.1... @albertadiabetes.bsky.social
Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants
Arthur and Nguyen et al. leverage iPSCORE, a large collection of three early developmental-like
tissues with corresponding molecular datasets (RNA-seq, ATAC-seq, H3K27ac ChIP-seq),
to map over 70,000 ...
www.cell.com
February 23, 2025 at 5:19 PM
Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Geming Lu
High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of #diabetic #kidney disease by inhibiting the Th1 response tinyurl.com/nhhj48sx 🔓
High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response - Diabetologia
Aims/hypothesis Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular respo...
tinyurl.com
February 11, 2025 at 12:18 PM
High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of #diabetic #kidney disease by inhibiting the Th1 response tinyurl.com/nhhj48sx 🔓
Reposted by Geming Lu
Dear Friends,
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas
Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin secreting beta cells has been observed in mouse but not in human islets1. Here, we analyzed the largest single cell d...
www.biorxiv.org
February 20, 2025 at 4:24 PM
Dear Friends,
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome | Science Translational Medicine www.science.org/doi/10.1126/...
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome
β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.
www.science.org
February 19, 2025 at 8:26 PM
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome | Science Translational Medicine www.science.org/doi/10.1126/...
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues | Science www.science.org/doi/10.1126/...
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...
www.science.org
February 8, 2025 at 11:47 PM
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues | Science www.science.org/doi/10.1126/...
Reposted by Geming Lu
🚨 Excited to share new results! We find that beta cells activate innate immune signaling to adapt to obesity or metabolic stress by promoting both Parkin dependent and independent mitophagy.
Mitophagy FTW! We'd be honored if you gave it a read. 😀
www.biorxiv.org/content/10.1...
Mitophagy FTW! We'd be honored if you gave it a read. 😀
www.biorxiv.org/content/10.1...
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy
Activation of innate immune signaling occurs during the progression of immunometabolic diseases, including type 2 diabetes (T2D), yet the impact of innate immune signaling on glucose homeostasis is co...
www.biorxiv.org
February 4, 2025 at 11:00 AM
🚨 Excited to share new results! We find that beta cells activate innate immune signaling to adapt to obesity or metabolic stress by promoting both Parkin dependent and independent mitophagy.
Mitophagy FTW! We'd be honored if you gave it a read. 😀
www.biorxiv.org/content/10.1...
Mitophagy FTW! We'd be honored if you gave it a read. 😀
www.biorxiv.org/content/10.1...
Reposted by Geming Lu
