Chris Frith 🚲🌳♻️🕊️⚡️🩺
@bulldoc.bsky.social
#Earthcarer #Carbonstorer
#Electronmaker #Sheepherder #treemeadow #bioforestry
🏏@BLCC
⚽️@HerefordFC.bsky.social
#formerGP #NHSinformatician
#procrastinator #coddiwompler
#Electronmaker #Sheepherder #treemeadow #bioforestry
🏏@BLCC
⚽️@HerefordFC.bsky.social
#formerGP #NHSinformatician
#procrastinator #coddiwompler
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
passivhaus retrofits and heat pumps solve this
Europe is America's biggest customer for fossil gas exports, by a pretty decent margin. One hell of a time to be directly antagonising and alienating the key customer for the already-shaky LNG boom in the US
www.netzeroinvestor.net/news-and-vie...
www.netzeroinvestor.net/news-and-vie...
January 18, 2026 at 3:20 PM
passivhaus retrofits and heat pumps solve this
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
On Mondays at 9 am, I come out of AI jail. I spend a day analysing my data using my allocated quota of AI power, then by 5 pm I'm back in AI jail until 9 am the following week. Can't wait till Oxford has a better system of distributing the resource. How do other universities do it?
#academicsky
#academicsky
January 19, 2026 at 6:42 PM
On Mondays at 9 am, I come out of AI jail. I spend a day analysing my data using my allocated quota of AI power, then by 5 pm I'm back in AI jail until 9 am the following week. Can't wait till Oxford has a better system of distributing the resource. How do other universities do it?
#academicsky
#academicsky
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
The Scots. A great bunch of lads.
January 18, 2026 at 11:00 AM
The Scots. A great bunch of lads.
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
On why the α-Syn SAA test cannot inform on #Parkinsons severity, biology, risk, or prognosis. In this article, I reflect on why "seeding activity" extracted from "kinetic parameters" can never reflect disease activity. linkedin.com/pulse/why-la... via @linkedin.com
Why the latest test for Parkinson’s cannot be quantitative –only binary (yes/no)
The α-Synuclein Seed Amplification Assay (α-Syn SAA) In response to many biological exposures, monomeric (normal) α-synuclein transforms into fibrillar (abnormal) aggregates, which we call Lewy pathol...
linkedin.com
November 26, 2025 at 11:15 PM
On why the α-Syn SAA test cannot inform on #Parkinsons severity, biology, risk, or prognosis. In this article, I reflect on why "seeding activity" extracted from "kinetic parameters" can never reflect disease activity. linkedin.com/pulse/why-la... via @linkedin.com
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
How does physics inform neurodegeneration? Supersaturation lowers the nucleation barrier for the precipitation of monomeric proteins into their pathological state. In normal aging, replacement matches loss; in accelerated aging, it does not. (1/4)
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Physics of Protein Aggregation in Normal and Accelerated Brain Aging
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age-related exposures (e.g., microbes, nanoparticles). Persistent soluble-to-insoluble phase transition de....
onlinelibrary.wiley.com
June 27, 2025 at 9:50 PM
How does physics inform neurodegeneration? Supersaturation lowers the nucleation barrier for the precipitation of monomeric proteins into their pathological state. In normal aging, replacement matches loss; in accelerated aging, it does not. (1/4)
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
A man genetically destined to develop early Alzheimer's… doesn’t. Why?
A Nature study explores possible explanations: tau pathology limited to the occipital region, significant heat exposure, and a proteomic profile rich in heat shock proteins.
Anything else? (1/4)
🔗 www.nature.com/articles/s41...
A Nature study explores possible explanations: tau pathology limited to the occipital region, significant heat exposure, and a proteomic profile rich in heat shock proteins.
Anything else? (1/4)
🔗 www.nature.com/articles/s41...
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine
A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.
www.nature.com
February 18, 2025 at 1:54 AM
A man genetically destined to develop early Alzheimer's… doesn’t. Why?
A Nature study explores possible explanations: tau pathology limited to the occipital region, significant heat exposure, and a proteomic profile rich in heat shock proteins.
Anything else? (1/4)
🔗 www.nature.com/articles/s41...
A Nature study explores possible explanations: tau pathology limited to the occipital region, significant heat exposure, and a proteomic profile rich in heat shock proteins.
Anything else? (1/4)
🔗 www.nature.com/articles/s41...
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
Vladimir Putin, a war criminal and dictator, has reportedly been invited to join the Board of Peace for Gaza - a sheer mockery of the horrific situations in Gaza and Ukraine, where the paths to peace remain fragile at best and countless lives hang in the balance.
news.sky.com/story/putin-...
news.sky.com/story/putin-...
Vladimir Putin invited to join 'Peace Council' for Gaza, Kremlin says
Donald Trump is to head a Board of Peace for Gaza, which also features Sir Tony Blair on the executive committee. But separately, the US president has asked 60 world leaders to become members.
news.sky.com
January 19, 2026 at 1:12 PM
Vladimir Putin, a war criminal and dictator, has reportedly been invited to join the Board of Peace for Gaza - a sheer mockery of the horrific situations in Gaza and Ukraine, where the paths to peace remain fragile at best and countless lives hang in the balance.
news.sky.com/story/putin-...
news.sky.com/story/putin-...
I am once again having to use a petrol non-plug in hybrid as one of the biggest national hire car companies have no electric cars available. Can we and the government encourage both hire and fleet operators to use cleaner greener vehicles please?
January 17, 2026 at 5:28 PM
I am once again having to use a petrol non-plug in hybrid as one of the biggest national hire car companies have no electric cars available. Can we and the government encourage both hire and fleet operators to use cleaner greener vehicles please?
Why Trump ignoring global trade rules and getting involved with wars leads to global isolation and instability for us all:
leftfootforward.org/2026/01/dona...
leftfootforward.org/2026/01/dona...
Donald Trump’s imperialism is the latest tool to advance the hegemony of US capital
Trump's policies are not isolationism. They're seeking to thwart the emergence of a multipolar world.
leftfootforward.org
January 17, 2026 at 10:06 AM
Why Trump ignoring global trade rules and getting involved with wars leads to global isolation and instability for us all:
leftfootforward.org/2026/01/dona...
leftfootforward.org/2026/01/dona...
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
Outrageous bare-faced lies - it’s extraordinary what the right wing press can get away with.
Thank you @drsimevans.carbonbrief.org for such a thorough debunking
Thank you @drsimevans.carbonbrief.org for such a thorough debunking
Truly wild that the Sun, Daily Mail, Daily Express & Daily Telegraph all covered false claims that net-zero will "cost" £7.6bn – or even £9tn – which assumes we could have free gas, free petrol, free petrol cars & free gas power plants if we scrapped net-zero
More here: bsky.app/profile/drsi...
More here: bsky.app/profile/drsi...
January 13, 2026 at 10:46 AM
Outrageous bare-faced lies - it’s extraordinary what the right wing press can get away with.
Thank you @drsimevans.carbonbrief.org for such a thorough debunking
Thank you @drsimevans.carbonbrief.org for such a thorough debunking
@macclesfieldfc.bsky.social congratulations on taking our crown as the greatest FA cup giantkiller v Newcastle United - can’t wait for our National League North clash later this season ;-) Good luck in the cup. Man City next 👍
January 11, 2026 at 11:02 AM
@macclesfieldfc.bsky.social congratulations on taking our crown as the greatest FA cup giantkiller v Newcastle United - can’t wait for our National League North clash later this season ;-) Good luck in the cup. Man City next 👍
55kg of CO2 is produced per person flying Birmingham to Jersey and back in a full EasyJet Airbus 330 which is roughly equal to the amount of CO2 absorbed by two trees growing for several decades by which time they need replacing!?
January 6, 2026 at 9:17 PM
55kg of CO2 is produced per person flying Birmingham to Jersey and back in a full EasyJet Airbus 330 which is roughly equal to the amount of CO2 absorbed by two trees growing for several decades by which time they need replacing!?
This means that doing our bit to reverse the direction the world’s climate is changing is more important than ever.
Could you reduce your carbon footprint? Eg by recycling, using green (preferably public) transport or encouraging the government to free electricity from the price of a barrel of oil.
Could you reduce your carbon footprint? Eg by recycling, using green (preferably public) transport or encouraging the government to free electricity from the price of a barrel of oil.
2025 has broken historical climate records, with provisional Met Office figures showing it has been both the warmest and sunniest year on record for the UK.
Find out more: www.metoffice.gov.uk/about-us/new...
Find out more: www.metoffice.gov.uk/about-us/new...
January 2, 2026 at 3:37 PM
This means that doing our bit to reverse the direction the world’s climate is changing is more important than ever.
Could you reduce your carbon footprint? Eg by recycling, using green (preferably public) transport or encouraging the government to free electricity from the price of a barrel of oil.
Could you reduce your carbon footprint? Eg by recycling, using green (preferably public) transport or encouraging the government to free electricity from the price of a barrel of oil.
substackcdn.com
January 2, 2026 at 3:33 PM
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
How do we minimize upfront carbon and operating emissions while improving health and comfort with the least stuff for the most people? The answer may not be “fabric first.” It may be a heat pump and a solar panel. It may be a good pair of long underwear. In 2026, I will not be so doctrinaire.
In the age of heat pumps, are "fabric first" retrofits a thermal bridge too far?
My question for 2026: How do we minimize upfront carbon and operating emissions while improving health and comfort with the least stuff for the most people?
lloydalter.substack.com
January 2, 2026 at 12:27 PM
How do we minimize upfront carbon and operating emissions while improving health and comfort with the least stuff for the most people? The answer may not be “fabric first.” It may be a heat pump and a solar panel. It may be a good pair of long underwear. In 2026, I will not be so doctrinaire.
Coughs & Hicups were and still are the bread and butter of your GP not A&E unless you don’t understand risk analysis or the benefit of a targeted clinical history and assessment or you are so impatient and can’t understand the benefit of time and wish the morbidity and anxiety of over investigation.
December 31, 2025 at 5:37 AM
Coughs & Hicups were and still are the bread and butter of your GP not A&E unless you don’t understand risk analysis or the benefit of a targeted clinical history and assessment or you are so impatient and can’t understand the benefit of time and wish the morbidity and anxiety of over investigation.
Meanwhile those who want to reside and build in the Rivers Wye & Lugg catchment areas are having to buy phosphate credits from either Hfds Council or Welsh Water to compensate for the ongoing pollution of our rivers from both human and agricultural waste which the Environment Agency fails to stop.
If we are to truly grasp the nettle on the issue of agricultural pollution in the Wye, we need a Water Protection Zone - I pressed the government to meet with me and other local MPs to discuss how we can progress implementation of this.
December 18, 2025 at 8:24 PM
Meanwhile those who want to reside and build in the Rivers Wye & Lugg catchment areas are having to buy phosphate credits from either Hfds Council or Welsh Water to compensate for the ongoing pollution of our rivers from both human and agricultural waste which the Environment Agency fails to stop.
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
Currently, new housing is often poorly-served by public transport.
Building around railway stations is good, but not enough.
Developments need good-quality, integrated public transport, walking & cycling networks, available to residents from Day 1.
www.gov.uk/government/n...
Building around railway stations is good, but not enough.
Developments need good-quality, integrated public transport, walking & cycling networks, available to residents from Day 1.
www.gov.uk/government/n...
Housing Sec pledges to 'go further than ever before' to hit 1.5 million homes
The government has launched a major consultation on a revamped National Planning Policy Framework today.
www.gov.uk
December 18, 2025 at 5:49 PM
Currently, new housing is often poorly-served by public transport.
Building around railway stations is good, but not enough.
Developments need good-quality, integrated public transport, walking & cycling networks, available to residents from Day 1.
www.gov.uk/government/n...
Building around railway stations is good, but not enough.
Developments need good-quality, integrated public transport, walking & cycling networks, available to residents from Day 1.
www.gov.uk/government/n...
As we see an overnight drop in max temp from 40C to 30C in Adelaide and the nearby salty Lake Eyre filling last year for the first time in 25 years hopefully we won’t allow greed and wars to be used as an excuse to drop our net zero targets? #theashes
Plausible worst-case climate futures and extreme events for the UK
Paper by Arnell et al.: agupubs.onlinelibrary.wiley.com/doi/10.1029/...
Article: www.theguardian.com/environment/...
Paper by Arnell et al.: agupubs.onlinelibrary.wiley.com/doi/10.1029/...
Article: www.theguardian.com/environment/...
‘Massive disruption’: UK’s worst-case climate crisis scenarios revealed by scientists
Scientists say government must prepare for unlikely but ‘plausible’ 4C rise in temperature and a 2-metre rise in sea levels
www.theguardian.com
December 18, 2025 at 8:04 PM
As we see an overnight drop in max temp from 40C to 30C in Adelaide and the nearby salty Lake Eyre filling last year for the first time in 25 years hopefully we won’t allow greed and wars to be used as an excuse to drop our net zero targets? #theashes
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
A major new YouGov poll of 2,600+ people shows:
78% favour solar
63% support onshore wind
70% back offshore wind
And 70% would support a solar farm near their own home.
That’s a landslide.
78% favour solar
63% support onshore wind
70% back offshore wind
And 70% would support a solar farm near their own home.
That’s a landslide.
December 16, 2025 at 3:49 PM
A major new YouGov poll of 2,600+ people shows:
78% favour solar
63% support onshore wind
70% back offshore wind
And 70% would support a solar farm near their own home.
That’s a landslide.
78% favour solar
63% support onshore wind
70% back offshore wind
And 70% would support a solar farm near their own home.
That’s a landslide.
Shouldn’t the General Medical council (who uphold medical ethics and protect the public be distancing themselves from resident doctors who threaten to go on strike?
December 16, 2025 at 5:10 AM
Shouldn’t the General Medical council (who uphold medical ethics and protect the public be distancing themselves from resident doctors who threaten to go on strike?
They will be 30kg lighter, 10cm narrower and have engines with a near 50-50 split between electric and internal combustion power - and use FULLY sustainable fuels #2026F1rules
Combustion produces CO2 unless hydrogen is the fuel to be used? Good start but the teams flight fuels need changing too.
Combustion produces CO2 unless hydrogen is the fuel to be used? Good start but the teams flight fuels need changing too.
December 12, 2025 at 3:15 AM
They will be 30kg lighter, 10cm narrower and have engines with a near 50-50 split between electric and internal combustion power - and use FULLY sustainable fuels #2026F1rules
Combustion produces CO2 unless hydrogen is the fuel to be used? Good start but the teams flight fuels need changing too.
Combustion produces CO2 unless hydrogen is the fuel to be used? Good start but the teams flight fuels need changing too.
Should there be a frequent flyer tax?
A new report by Stay Grounded and the New Economics Foundation has found that introducing a frequent flyer levy could reduce air travel emissions by 21% and raise £54bn a year.
A new report by Stay Grounded and the New Economics Foundation has found that introducing a frequent flyer levy could reduce air travel emissions by 21% and raise £54bn a year.
December 10, 2025 at 2:25 AM
Should there be a frequent flyer tax?
A new report by Stay Grounded and the New Economics Foundation has found that introducing a frequent flyer levy could reduce air travel emissions by 21% and raise £54bn a year.
A new report by Stay Grounded and the New Economics Foundation has found that introducing a frequent flyer levy could reduce air travel emissions by 21% and raise £54bn a year.
Reposted by Chris Frith 🚲🌳♻️🕊️⚡️🩺
Here's our reaction to today's Budget...
November 26, 2025 at 3:29 PM
Here's our reaction to today's Budget...