Emil Lou, MD,PhD,FACP
@cancerassassin1.bsky.social
2.2K followers 600 following 240 posts
Physician-Scientist/Clinical Cancer Biologist/GI Medical Oncologist. In lab: Cancer Cell Biology, uncovering how #TunnelingNanotubes drive ChemoResistance. https://med.umn.edu/dom/divisions/hematology-oncology-and-transplantation/research/emil-lou-lab
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cancerassassin1.bsky.social
Performing some team teaching today on Neuroendocrine Cancers by sharing this excellent figure from 2024 expert consensus statement by Drs. Chauhan et al
@cacancerjournal.bsky.social acsjournals.onlinelibrary.wiley.com/doi/10.3322/...
Reposted by Emil Lou, MD,PhD,FACP
natureportfolio.nature.com
The Nobel prizes will be announced starting Monday, and they’re considered the most famous awards in science. In the past few years, though, a number of other prizes have popped up. Nature examines how these prizes compare with one another. 🧪
These science prizes want to rival the Nobels: how do they compare?
Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?
go.nature.com
Reposted by Emil Lou, MD,PhD,FACP
cancergrand.bsky.social
#CancerGrandChallenges IMAXT in @nature.com:
Using CloneSeq-SV, the team tracked ovarian cancer clones and found:

• Resistant clones often exist from diagnosis
• ctDNA spotted recurrence ~8 months earlier than imaging
• Actionable drivers (e.g. ERBB2) can be revealed

www.nature.com/articles/s41...
cancerassassin1.bsky.social
Fascinating bit of the history of #oncology that came to my attention recently:

The world's oldest known cancerous tumor - 1.7 million years! from Swartkrans Cave, South Africa - with rendering included in this 2016 publication
sajs.co.za/article/view...
cancerassassin1.bsky.social
#TunnelingNanotubes are membranous extensions of cells that mediate cell contact-dependent intercellular transport of organelles and viruses. In our recent study of SARS-CoV-2 in tissue from patients, we found them in post-infected samples from matched tissue specimens. www.cell.com/iscience/ful...
Reposted by Emil Lou, MD,PhD,FACP
jama.com
JAMA @jama.com · 10d
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types.

ja.ma/46pab9T
JAMA Insights: How to Communicate Medical Numbers. It outlines recommendations for conveying risk, adjusting numerators, communicating probability changes, using visualizations, and providing context, with examples of problematic and preferred communication styles.
Reposted by Emil Lou, MD,PhD,FACP
c0nc0rdance.bsky.social
So you're a scientist about to face a government shutdown?

Have you considered becoming a rock star?

It's easy AND profitable! 🎸🧪

Let's list off five scientists who turned rockers:
Reposted by Emil Lou, MD,PhD,FACP
natureportfolio.nature.com
There are strong indications that micro- and nanoplastics exposure negatively impacts human health, but a robust evidence base is lacking. A Review in Nature Medicine focuses on the current state of the science. go.nature.com/47H9Q3s #medsky 🧪
This is figure 1, which shows MNP exposure and cellular effects.
Reposted by Emil Lou, MD,PhD,FACP
chenxinli2.bsky.social
Re-upping this: For those of you having new students in the lab, I have curated a YouTube playlist on molecular biology: www.youtube.com/playlist?lis...

I usually have my students watch it before I show them how to do it in the lab.
Molecular_Bio - YouTube
www.youtube.com
Reposted by Emil Lou, MD,PhD,FACP
nejm.org
In patients with localized colorectal cancer and PIK3CA hotspot mutations in exon 9 or 20, daily low-dose aspirin resulted in a significantly lower recurrence rate than placebo. Full ALASCCA phase 3 trial results and Research Summary: nej.md/4mpKXNp

#MedSky #Oncology
The New England Journal of Medicine                   
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer 
A Research Summary based on Martling A et al. | 10.1056/NEJMoa2504650 | Published on September 18, 2025 

Visual representations of the patients in the trial and the treatments they were assigned.                       

Read the full Research Summary at NEJM.org.
Reposted by Emil Lou, MD,PhD,FACP
ncweaver.skerry-tech.com
Why is this horrible for Universities?

Just about everyone who isn't a citizen or green card holder already who's hired for a tenure track faculty position is hired through an H1B and then, after 3-5 years, applies for a green card.

This is literally "No more foreign professors can be hired"
gergely.pragmaticengineer.com
Those on an H1B cannot return to the US from tomorrow (Sunday) unless paying $100K. This is an out-of-the blue presidential action. We’ll see software engineers stranded abroad.

One easy to predict outcome: those on US visas will travel less… for work, for conferences etc.
cancerassassin1.bsky.social
Thank you - much of that is to be determined; but one thing we discovered is that for immunosuppressed patients with cancer and transplant, severe reactions to COVID-19 infection mirrored Graft-vs-Host disease or transplant rejection, so physicians in this field will need to be aware of that aspect.
Reposted by Emil Lou, MD,PhD,FACP
sbpcancercenter.bsky.social
Today 62 National Cancer Institute (NCI)-Designated Cancer Centers released a statement reinforcing the importance of HPV vaccination.

HPV vaccination is safe and protects against six types of cancer – including oropharyngeal, cervical, and anal cancers.

#HPVvaccine #HPVvax #EndHPVCancers
cancerassassin1.bsky.social
Precision nutrition, microbiome, viral reservoirs…and more!

Check out Episode 2 of our Only Oncologists in the Building videocast and smash that Subscribe button! With Drs. @shrutipatelmd.bsky.social & @shaalanbeg.bsky.social

www.youtube.com/watch?v=kSLe...
#oncology #video #podcast #YouTube
Precision nutrition, microbiome and viral reservoirs.
YouTube video by Only Oncologists In the Building
www.youtube.com
Reposted by Emil Lou, MD,PhD,FACP
erictopol.bsky.social
"We will never know what diseases might have been cured or what advances in technology might have been invented had the lights not gone out in the labs."
www.nytimes.com/2025/09/08/o...
Opinion | We Are Watching a Scientific Superpower Destroy Itself
www.nytimes.com
Reposted by Emil Lou, MD,PhD,FACP
cellpress.bsky.social
Special issue presented by @cp-neuron.bsky.social on cancer neuroscience⚡🧠 www.cell.com/neuron/issue...
The cover depicts how tumors and the nervous system interact, reciprocally influencing each other's biology. This dynamic crosstalk can modify not only cancer progression and metastasis but also host behavior. 

Cover design and illustration by Naola Leconte, Cell Press.
cancerassassin1.bsky.social
From our U of MN Medical School research team: press release highlighting our recent publication in @cellpress.bsky.social journal @cp-iscience.bsky.social w/implications for Long COVID in immunocompromised patients with cancer and transplant:

med.umn.edu/news/researc...
#COVID #LongCOVID
Reposted by Emil Lou, MD,PhD,FACP
asm.org
ASM @asm.org · Sep 3
As national medical, scientific, public health and patient organizations, we call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Read our statement: asm.org/press-releas...
Joint Statement Calling for Secretary Kennedy Resignation
The American Society for Microbiology released a joint statement calling for the resignation of HHS Secretary Robert F. Kennedy Jr.
asm.org