Castañeda Lab at SU
@castanedalab.bsky.social
1.1K followers 610 following 54 posts
Using molecular biophysics, biochemistry, and cell biology to understand the intersection of protein quality control mechanisms and neurodegenerative disorders (ALS, FTD); IDPs, Ub biology, UBQLNs
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castanedalab.bsky.social
The power of collaborations! With @shaharsu.bsky.social, his PD @jessniblo.bsky.social and CALVADOS3 (thanks to @lindorfflarsen.bsky.social ) we show how STI1 (red) may engage with sequences that match transient helices within IDRs of Ub-binding shuttle protein Dsk2 www.biorxiv.org/content/10.1...
castanedalab.bsky.social
Super congratulations @alexholehouse.bsky.social ! Super excited for you and your research directions! Congrats!!!
Reposted by Castañeda Lab at SU
peiferlabunc.bsky.social
If you are a researcher whose lab uses FlyBase, consider a tax-deductible personal contribution. A lot of $100 contributions would help bridge the gap until we can set up a user fee system, and even $10 donations send the folks there the message we're behind them. Please share
My own donation
Reposted by Castañeda Lab at SU
Reposted by Castañeda Lab at SU
jeremymberg.bsky.social
Update on NIH funding through July (August 1 budget start dates)

Non-competitive renewal awards by month for fiscal year 2025

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A bar graph of the fraction of NIH non-competitive renewal awards received by month showing that fewer awards that expected to being given.
Reposted by Castañeda Lab at SU
dadrummond.art
Happy RNA Day to those who celebrate! 🧪 It’s AUG 1: the day we Met 🤓
Reposted by Castañeda Lab at SU
ardemp.bskyverified.social
BIG NEWS:

“Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.”

Thank you to members of the Senate Appropriations Committee on both sides of the aisle!

www.axios.com/pro/health-c...
Senate appropriators approve Labor-HHS bill with NIH bump
The vote and lawmaker comments show that most senators aren't going along with the White House's proposed 40% budget cut to NIH.
www.axios.com
Reposted by Castañeda Lab at SU
mikefeigin.bsky.social
“With these considerations, we expect to fund through the 4th percentile.”

There it is, in black and white, the destruction of cancer research in the US.
castanedalab.bsky.social
Yes I believe so, although the announcement is not planned for a couple more months: grants.gov/search-resul...
Lock
grants.gov
Reposted by Castañeda Lab at SU
tanjamittag.bsky.social
New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...
Reposted by Castañeda Lab at SU
fitzkeelab.bsky.social
As someone who has greatly benefited from the NSF MRI program, I'm sad to see that the 2025 submission window was canceled. www.nsf.gov/funding/oppo...
Major Research Instrumentation (MRI) Program:
www.nsf.gov
castanedalab.bsky.social
@jeremymberg.bsky.social to share to others - this is a forecasted NIGMS MIRA funding opportunity for established/new investigators as I know people have been asking (FOR-GM-27-002) - due date appears to be late Jan 2026: grants.gov/search-resul...
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grants.gov
Reposted by Castañeda Lab at SU
jeremymberg.bsky.social
This morning, courageous NIH workers shared a document they are calling the “Bethesda Declaration” with Dr. Bhattacharya, urging him to reverse some of the actions that are badly misaligned with progress toward the NIH mission.

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a woman in a black and white dress is making a funny face .
ALT: a woman in a black and white dress is making a funny face .
media.tenor.com
Reposted by Castañeda Lab at SU
dev-journal.bsky.social
To learn more about the story behind the paper, we caught up with first authors Yan Wu and Yiling Lan, and the corresponding author Heidi Hehnly @lovelessradio.bsky.social‬, an Associate Professor and Associate Director of the BioInspired Institute at @syracuseu.bsky.social
Yiling Lan (left), Heidi Hehnly (centre) and Yan Wu (right) in the zebrafish room at Syracuse University.
Reposted by Castañeda Lab at SU
paralkarlab.bsky.social
Fascinating new paper explaining why nucleoli have heterochromatin stacked around them.
labsantoro.bsky.social
Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...
Reposted by Castañeda Lab at SU
luciastrader.bsky.social
Biomolecular condensates are critical for organizing cellular contents, but most studies focus on phase separation driven by salt, pH, or temperature.
But what if intracellular movement also matters?
Here, we explore motility-induced condensation in the cell.
www.science.org/doi/10.1126/...
Active transport enables protein condensation in cells
The force generated by active transport modulates protein condensation.
www.science.org
castanedalab.bsky.social
The power of collaborations! With @shaharsu.bsky.social, his PD @jessniblo.bsky.social and CALVADOS3 (thanks to @lindorfflarsen.bsky.social ) we show how STI1 (red) may engage with sequences that match transient helices within IDRs of Ub-binding shuttle protein Dsk2 www.biorxiv.org/content/10.1...
Reposted by Castañeda Lab at SU
standupforscience.bsky.social
Behind every cure, every breakthrough, every treatment — is someone who needed it.

If NIH funding helped you, your research, or someone you love, your story can help protect it.

Share your “why” and help defend the future of NIH & science.

Fill out the form here:
docs.google.com/forms/d/e/1F...
Share Your “Why” In Support of a Strong National Institutes of Health
United for Medical Research (UMR) is launching a campaign called "My Why" to highlight the critical role of NIH funding and its impact on the education and careers of researchers and scientists as wel...
docs.google.com
castanedalab.bsky.social
I'm optimistic a new FOA for EI MIRA investigators will come in due time; the PAR 22-180 one was originally scheduled to expire May 17 (the day after the regular May 16 EI MIRA deadline).
Reposted by Castañeda Lab at SU
proteinmagnus.bsky.social
🚨We have an opening for a postdoc to use protein design techniques to developing and characterizing binders against intrinsically disordered proteins involved in neuroscience.

Experience in protein biochemistry and/or molecular neuroscience preferred.

Share: 🙏

mbg.au.dk/aktuelt/ledi...
Postdoc: De novo protein design for neuroscience - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Molekylærbiologi og Genetik - Neurobiologi, Aarhus Universitet
mbg.au.dk