Lightnews — Scholar-powered news

Reposted by Conner Langeberg

Jeanine Gezelle @jgezelle.bsky.social · Sep 2

Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...

A conserved viral RNA fold enables nuclease resistance across kingdoms of life

Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence

academic.oup.com

2 10 22

Reposted by Conner Langeberg

Evgenii Protasov @evgenii-protasov.bsky.social · Jul 9

Archaeal virus entry and egress
Archaea also have viruses and they are cool!
#microbiology #virology #virus #viruses
@femsmicro.org @femsjournals.bsky.social
academic.oup.com/microlife/ar...

Archaeal virus entry and egress

Abstract. Archaeal viruses display a high degree of structural and genomic diversity. Few details are known about the mechanisms by which these viruses ent

academic.oup.com

8 13

Reposted by Conner Langeberg

Nogales Lab @nogaleslab.bsky.social · Jul 7

Our work, co-led by @alfredo0712.bsky.social and @nlue8.bsky.social is out in @natsmb.nature.com Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and S. Kassube for their contributions and thanks to the reviewers for the suggestions that led to the final work.
www.nature.com/articles/s41...

Structural insights into transcriptional regulation by the helicase RECQL5 - Nature Structural & Molecular Biology

Florez Ariza and Lue et al. use cryo-electron microscopy to investigate how the RECQL5 helicase regulates transcription. Their structural findings suggest that RECQL5 can modulate RNA polymerase II’s ...

www.nature.com

1 12 38

Reposted by Conner Langeberg

Beckmann Lab @beckmannlab.bsky.social · May 26

We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

1 27 62

Conner Langeberg @clangeberg.bsky.social · May 15

Final grad paper is officially out! Grateful for the incredible team and all the support along the way!
www.nature.com/articles/s41...

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure - Nature Communications

Many flaviviruses generate specialized non-coding RNAs that resist degradation by host exonucleases, promoting viral infection. Here, the authors characterize an RNA element in Powassan virus, highlig...

www.nature.com

3 5

Reposted by Conner Langeberg

Erin Doherty @erinedoherty.bsky.social · Mar 31

Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.

Check it out:

A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway

Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signaling that share mechanistic features with human anti-viral systems. In these pathways, including CBASS a...

www.biorxiv.org

4 30 63

Reposted by Conner Langeberg

Honglue @honglue.bsky.social · Apr 3

Giving a seminar for the Genome Engineering Seminar Series at Harvard this Monday, April 7 at 1pm EST / 10am PST! 🎙️ I’ll be talking about our Cas9 work—if you’ve ever wondered what the recipe is for high-efficiency CRISPR genome editing, come hang out!🧬💥
📍 Zoom link: harvard.zoom.us/j/94394339529

8 8

Reposted by Conner Langeberg

Rita Strack @ritastrack.bsky.social · Feb 20

Really nice issue of RNA this month featuring many Perspective pieces on RNA in disease. rnajournal.cshlp.org/content/31/3...

Table of Contents — March 2025, 31 (3)

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

rnajournal.cshlp.org

6 27

Reposted by Conner Langeberg

Elena Rivas @rivaselenarivas.bsky.social · Feb 17

We present Rfam-based RNA structural alignments and other structure-based inputs for RNA 3D structure prediction by deep learning.
www.biorxiv.org/content/10.1...

5 12

Reposted by Conner Langeberg

Nature Biotechnology @natbiotech.nature.com · Feb 18

Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM

Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology

Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.

go.nature.com

2 14 60

Reposted by Conner Langeberg

Simon Kohl @saakohl.bsky.social · Feb 13

Latent Labs comes out of stealth today with $50M funding. Our goal? To push the frontiers of generative biology, giving partners instant access to tools capable of accelerating drug design

2 13 40

Reposted by Conner Langeberg

Chandrima Majumdar @c-majumdar.bsky.social · Feb 12

I had the pleasure of co-hosting this new career exploration podcast from ASBMB- tune in to hear from my fellow committee member Tom Kiselak about being a patent attorney!

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Feb 12

🎙️ASBMB's new series features interviews with biological and life sciences professionals about their careers!
ow.ly/268250UYcmx
🎧Check out episode 1: A conversation w/Tom Kiselak (Thermo Fisher Scientific), who holds a #PhD in analytical chemistry & works as a patent attorney: youtu.be/enBtSSTQT9A.

In conversation with... Tom Kiselak

YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)

youtu.be

3 5

Conner Langeberg @clangeberg.bsky.social · Feb 10

Excited to see this work finally out, it was a pleasure to be involved!

Innovative Genomics Institute @innovativegenomics.bsky.social · Feb 10

New article from @jhdcate.bsky.social and collaborators in @narjournal.bsky.social: RNA elements required for the high efficiency of West Nile virus-induced ribosomal frameshifting doi.org/10.1093/nar/... 🧪🧬🦠

RNA elements required for the high efficiency of West Nile virus-induced ribosomal frameshifting

Abstract. West Nile virus (WNV) requires programmed −1 ribosomal frameshifting for translation of the viral genome. The efficiency of WNV frameshifting is

doi.org

2

Reposted by Conner Langeberg

Eugen Pfeifer @eugenpfeifer.bsky.social · Feb 10

Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025...
Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium
@inrae-france.bsky.social [email protected][email protected]! Many thanks for this great journey!🙌

Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome.

The use of antibiotics disrupts the gut microbiota, potentially leading to long-term health issues and the spread of resistance. To investigate the impact of antibiotics on phage populations, we follo...

doi.org

3 26 49

Reposted by Conner Langeberg

Innovative Genomics Institute @innovativegenomics.bsky.social · Feb 4

Today, the IGI turns 10! We’ve grown from a fledgling initiative focused around developing #CRISPR tools to a full-blown research institute bringing together leaders in basic & translational research! ⚕️💊🌱☀️

Take a look at our timeline & key achievements from our first decade: ow.ly/GzVt50UTsbP

3 19

Reposted by Conner Langeberg

cryoEM papers @cryoempapers.bsky.social · Feb 3

A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions pubmed.ncbi.nlm.nih.gov/39893634/ #cryoem

5 9

Conner Langeberg @clangeberg.bsky.social · Feb 4

Thrilled to have been involved in this work and looking forward to what the Sherlock Lab has in store!

cryoEM papers @cryoempapers.bsky.social · Feb 3

A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions pubmed.ncbi.nlm.nih.gov/39893634/ #cryoem

1

Reposted by Conner Langeberg

C-GEM, the NSF Center for Genetically Encoded Materials @cgemcci.bsky.social · Feb 3

✨ New from C-GEM in ACS Central Science:
Thioesters Support Efficient Protein Biosynthesis by the Ribosome
pubs.acs.org/doi/10.1021/...

Congrats to Alexandra & Jacob, along with Isaac, Jess, @alexsolivan.bsky.social, @nxhamlish.bsky.social, Katie, Alanna, Jamie, and Scott!
#NSFfunded @pubs.acs.org

Thioesters Support Efficient Protein Biosynthesis by the Ribosome

Thioesters are critical chemical intermediates in numerous extant biochemical reactions and are invoked as key reagents during prebiotic peptide synthesis on an evolving Earth. Here we asked if a thio...

pubs.acs.org

1 10 24

Reposted by Conner Langeberg

Gopal Jayaraj @gopaljayaraj.bsky.social · Jan 31

www.cell.com/cell/fulltex...

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation

Ribosomes cooperate through transient collisions to ensure efficient translation.

www.cell.com

17 38

Reposted by Conner Langeberg

Sorek Lab @soreklab.bsky.social · Jan 30

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria

We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase

Congrats Francois Rousset, Ilya Osterman and coauthors!

www.science.org/doi/10.1126/...

1 37 87

Reposted by Conner Langeberg

Sorek Lab @soreklab.bsky.social · Jan 30

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems

CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems

Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...

4 67 190

Reposted by Conner Langeberg

Clausen Lab @clausenlab.bsky.social · Jan 29

scary but fascinating - cells have a degradation pathway that hunts down C-terminal scars (amides!) on damaged proteins. just wow. chemical biology plus CRISPR at its best. big congrats to all authors!

www.nature.com/articles/s41...

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

www.nature.com

1 34 110

Reposted by Conner Langeberg

DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · Jan 30

In addition to today's posted work by @cryoclem.bsky.social on Archaeal ribosomes we further expanded RAPPL (www.biorxiv.org/content/10.1...) on multiple other complexes that work with ribosomes, subunits or even off the ribosome. Soon more...

1 4

Reposted by Conner Langeberg

Nature @nature.com · Jan 30

Nature research paper: CARD domains mediate anti-phage defence in bacterial gasdermin systems

https://go.nature.com/3CvoD3W

CARD domains mediate anti-phage defence in bacterial gasdermin systems - Nature

Caspase recruitment domains (CARDs) are present in defence systems that protect bacteria against phage, where the bacterial CARD domain is essential for protease-mediated activation of bacterial gasdermins that promote cell death.

go.nature.com

2 18

Reposted by Conner Langeberg

Landon Getz @landongetz.bsky.social · Jan 27

It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
rdcu.be/d7EsN

Integrons are anti-phage defence libraries in Vibrio parahaemolyticus

Nature Microbiology - Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage...

rdcu.be

4 28 83