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Reposted by Claudia Alvarez Carreño

Claudèle Lemay-St-Denis @claudele.bsky.social · 16h

How does catalysis emerge from non-catalytic domains?

In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.

A striking case of catalysis evolving from binding.

Molecular Biology and Evolution @molbioevol.bsky.social · 5d

@claudele.bsky.social et al. studied the fundamental question of how enzymatic activity emerges by focusing on type B dihydrofolate reductases, suggesting DfrB domains evolved rudimentary catalysis from a binding capacity.

🔗 doi.org/10.1093/molbev/msaf215

#evobio #molbio

From Binding to Catalysis: Emergence of a Rudimentary Enzyme Conferring Intrinsic Antibiotic Resistance

Abstract. How does enzymatic activity emerge? To shed light on this fundamental question, we study type B dihydrofolate reductases (DfrB), which were disco

doi.org

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · 2d

The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU):

Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t”
Date: October 14th, 5 pm CET
Registration link: tinyurl.com/prose-seminar2

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Reposted by Claudia Alvarez Carreño

Nature @nature.com · 16d

Modelling suggests that most Caribbean coral reefs will erode by the year 2100 as sea-level rise outpaces reef growth and limits potential reef restoration

go.nature.com/42229kK

Caribbean coral reefs are threatened by rising seas

Modelling suggests that most Caribbean coral reefs will erode by the year 2100 as sea-level rise outpaces reef growth and limits potential reef restoration.

go.nature.com

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Reposted by Claudia Alvarez Carreño

Jeremy Berg @jeremymberg.bsky.social · 18d

ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS

Comment period ends September 29th

www.federalregister.gov/documents/20...

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Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media

Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...

www.federalregister.gov

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · 23d

Happy to share Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record 🧪
It appears as part of a Special Section in @genomebiolevol.bsky.social organized by @cpuentelelievre.bsky.social @proteinmechanic.bsky.social and J. Douglas

doi.org/10.1093/gbe/...

Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record

Abstract. Protein folds are structural units defined by the number, type, arrangement, and orientation of their core secondary structural elements. The uni

doi.org

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Reposted by Claudia Alvarez Carreño

Claudia Alvarez Carreño @claudiaalcar.bsky.social · Sep 2

The ProSE seminars are back after a summer break. The next speaker is Nir Ben-Tal on "Contrastive learning unites sequence and structure in a global representation of protein space".
Date: September 9
Time: 5pm CET
Register here: tinyurl.com/prose-seminar2

Please share!
🧪 #mevosky

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · Sep 2

Shout-out to @caro-rocha.bsky.social, @lacholt.bsky.social, @zachary-ardern.bsky.social, @romeritos.bsky.social and @hassanzaman.bsky.social

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · Sep 2

The ProSE seminars are back after a summer break. The next speaker is Nir Ben-Tal on "Contrastive learning unites sequence and structure in a global representation of protein space".
Date: September 9
Time: 5pm CET
Register here: tinyurl.com/prose-seminar2

Please share!
🧪 #mevosky

2 6 9

Reposted by Claudia Alvarez Carreño

Genome Biology and Evolution @genomebiolevol.bsky.social · Aug 26

In a new GBE Review, @cpuentelelievre.bsky.social @proteinmechanic.bsky.social & J. Douglas give an overview on protein structural phylogenetics, how to obtain evolutionary insights from structural data, and key applications and future directions.

🔗 doi.org/10.1093/gbe/evaf139

#genome #evolution

Puente-Lelievre et al. have systematically reviewed how protein structures can be used to trace evolutionary histories. This rapidly advancing field has not yet caught up with the burgeoning databases of high quality protein structure predictions provided by AlphaFold and other tools.

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Reposted by Claudia Alvarez Carreño

EDI Caucus @edicaucus.bsky.social · Aug 25

Help us gauge the state of the UK's research & innovation sector in terms of preventing and handling bullying & harassment. Please share our survey of anyone who has witnessed or experienced it at work.

go.hw.ac.uk/EDICa/Bullyi...

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · Aug 21

Thrilled to see this out! Thank you for the shout out @chercheurjuteux.com!

Mathieu M.J.E. Rebeaud @chercheurjuteux.com · Aug 21

Beautiful work from @claudiaalcar.bsky.social, congrats!

Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record

academic.oup.com/gbe/article/...

Piecing Together the History of Protein Folds From a Fragmented Evolutionary Record

Abstract. Protein folds are structural units defined by the number, type, arrangement, and orientation of their core secondary structural elements. The uni

academic.oup.com

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Reposted by Claudia Alvarez Carreño

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Jul 30

[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

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Reposted by Claudia Alvarez Carreño

Iain Cheeseman @iaincheeseman.bsky.social · Jul 23

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells

In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

www.biorxiv.org

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Reposted by Claudia Alvarez Carreño

Ajasja💻🧬🔬 @ajasjaljubetic.bsky.social · Jun 26

Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉

Come join us for three days of protein design fun! (October 20-22, 2025)

Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org

We are looking forward to seeing you!

Please share this far and wide:)

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Reposted by Claudia Alvarez Carreño

Geo Santiago-Martínez @geosantiagom.bsky.social · Jun 7

¿Te interesaría unirte a nuestro laboratorio como Postdoctoral Fellow?
¿Está interesado en investigar y contribuir a la comprensión del papel de los anaerobios en la salud humana?

Revisa la convocatoria Pew Latin American Fellows

¡Contáctame si cumples con los requisitos!
#Archaea #MicroSky

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Reposted by Claudia Alvarez Carreño

Society for Molecular Biology and Evolution @official-smbe.bsky.social · Apr 18

📖 SMBE journals on Bluesky

Interested in learning the latest advances in evolutionary biology, genomics, and molecular biology? Follow the SMBE sister journals MBE and GBE here on Bluesky and get updates on new articles coming out.

MBE: @molbioevol.bsky.social
GBE: @genomebiolevol.bsky.social

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Reposted by Claudia Alvarez Carreño

Claudia Alvarez Carreño @claudiaalcar.bsky.social · May 29

Join us for the next ProSE Seminar!
We are excited to welcome Sophie Heiding for a talk on "Computational Insights into Protein Adaptation Across Environmental Gradients"
Date: June 10
Time: 4PM CET
Register here: tinyurl.com/prose-seminar2
Please share!
🧪 #MEvoSky

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · May 29

Join us for the next ProSE Seminar!
We are excited to welcome Sophie Heiding for a talk on "Computational Insights into Protein Adaptation Across Environmental Gradients"
Date: June 10
Time: 4PM CET
Register here: tinyurl.com/prose-seminar2
Please share!
🧪 #MEvoSky

6 12

Reposted by Claudia Alvarez Carreño

Daniel Bolnick @danielbolnick.bsky.social · May 24

Reminder that SSE members in Brazil, Colombia, Mexico, India, and 152 low-income countries around the world can still get FREE registration for the virtual Evolution meeting! Please share with your colleagues: www.evolutionsociety.org/index.php?mo...

Membership

Site description

www.evolutionsociety.org

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Reposted by Claudia Alvarez Carreño

Genome Biology and Evolution @genomebiolevol.bsky.social · May 18

Happy International Museum Day!

Museums are essential repositories of specimens and information for biodiversity research. GBE has published much research in genomics and evolution that benefited from this crucial function of museums.

See below ⬇️ and continue supporting museum research

#IMD2025

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Reposted by Claudia Alvarez Carreño

Vikram Alva @vikramalva.bsky.social · May 12

Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...

@mpi-bio-fml.bsky.social

A snapshot of the HLp tetramer (purple) wrapping ~60 bp of DNA (green).

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Reposted by Claudia Alvarez Carreño

Claudia Alvarez Carreño @claudiaalcar.bsky.social · May 1

We are pleased to announce that the next speaker in the ProSE seminar series will be Dr. Klara Hlouchova with a talk on "Protein Structure Before LUCA"
May 13, 4PM CET
Registration link: tinyurl.com/prose-seminar4
Please share!

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Reposted by Claudia Alvarez Carreño

Zachary Ardern @zachary-ardern.bsky.social · May 10

Very interesting new study from authors including Nobel Prize winner David Baker.

I'm glad that it cites one of my related papers 😀

I've faced plenty of skepticism from editors & others about the importance of this line of research, perhaps this will shift ...
www.biorxiv.org/content/10.1...

Design of overlapping genes using deep generative models of protein sequences

In nature, viruses frequently evolve overlapping genes (OLG) in alternate reading frames of the same nucleotide sequence despite the drastically reduced protein sequence space resulting from the shari...

www.biorxiv.org

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Claudia Alvarez Carreño @claudiaalcar.bsky.social · May 1

We are pleased to announce that the next speaker in the ProSE seminar series will be Dr. Klara Hlouchova with a talk on "Protein Structure Before LUCA"
May 13, 4PM CET
Registration link: tinyurl.com/prose-seminar4
Please share!

18 34

Reposted by Claudia Alvarez Carreño

Sjors Scheres @sjorsscheres.bsky.social · Apr 25

Labour continues the stupid culture war politics of the previous govt. 😡 Cyclists killing pedestrians is super rare. There are so many more useful things the govt could spend their time on legislating, e.g making streets safer for cyclists.

www.theguardian.com/news/2025/ap...

Cyclists who kill pedestrians could be jailed for life under new law in England and Wales

Reckless cycling is currently prosecuted under legislation from the 1860s, with a maximum two-year jail sentence

www.theguardian.com

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