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Reposted by Cluster of Excellence CMFI

Andreas Peschel @andreaspeschel.bsky.social · Aug 25

How do keratinocytes sense bacterial commensals or pathogens?
@cmfi.bsky.social
Here is our recent review:
www.sciencedirect.com/science/arti...

Role of Formyl Peptide Receptor 2 and Toll-Like Receptor 2 in Skin Barrier Function and Atopic Dermatitis

The skin acts as a barrier against external threats and plays an important role in tissue repair. Skin cells, including keratinocytes, sense microbe-a…

www.sciencedirect.com

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Reposted by Cluster of Excellence CMFI

Healthcare in Europe (DE) @health-europe-de.bsky.social · Jul 28

#Antibiotika stören das #Mikrobiom im #Darm und ebnen so den Weg für Erkrankungen. Das gilt allerdings auch für viele Nicht-Antibiotika, zeigt eine neue Studie von @ghammeranne.bsky.social und @jdlcz.bsky.social ‪vom @lisamaierlab.bsky.social am @cmfi.bsky.social ‪der @unituebingen.bsky.social‬.

Studie: Nicht nur Antibiotika stören das Darm-Mikrobiom

Studie unter Leitung der Universität Tübingen: Viele Nicht-Antibiotika schwächen die natürliche Schutzfunktion des Darms, sodass sich krankmachende Bakterien leichter dort ansiedeln können

healthcare-in-europe.com

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Reposted by Cluster of Excellence CMFI

Khaled_Selim Lab @selimlab.bsky.social · Jul 28

A new doctor is born 😊🥳
Welcome with me Dr. Haffner, the first PhD student of the group after wonderful years @cmfi.bsky.social

Michael published 8 articles & a review with 3 as 1st author..
www.science.org/doi/10.1126/...

www.pnas.org/doi/10.1073/...

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Reposted by Cluster of Excellence CMFI

Daniel Petras @daniel-petras.bsky.social · Jul 27

New paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data:

www.nature.com/articles/s41...

Behind the paper story:
go.nature.com/45ljV4d

Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling - Nature Communications

To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. ...

www.nature.com

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Reposted by Cluster of Excellence CMFI

PLOS Biology @plosbiology.org · Jul 23

How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q

Left: Compound-promoter interaction network. Fifty-three significant compound-promoter interactions are shown as edges in a Sankey diagram connecting the compounds (left, source nodes) to the promoters (right, target nodes). Edge thickness represents mean Z-scores (n = 8), while node size represents the total number of interactions. Right: Proposed model for the molecular mechanism of caffeine-ciprofloxacin antagonism. Caffeine triggers expression of MicF small RNA in a Rob-dependent manner, which then binds to the 5′-UTR of ompF mRNA to inhibit and decrease OmpF protein levels. This ultimately prevents ciprofloxacin from entering the cell, resulting in caffeine-ciprofloxacin antagonism

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Cluster of Excellence CMFI @cmfi.bsky.social · Jul 24

Study finds #caffeine can weaken effectiveness of certain #antibiotics

Substances from natural environment can trigger bacteria's alert systems – implications for future therapeutic approaches?

Read the press release here: www.cmfi.uni-tuebingen.de/en/news-even...

@unituebingen.bsky.social

Scientist Ana Rita Brochado and her lab team member Laura Sniegula look at data from the pipetting robot. With this laboratory tool the team investigated the effect of 94 different substances – including antibiotics, prescription drugs, and food ingredients – on the bacterium E. coli, a potential pathogen. © Leon Kokkoliadis/CMFI, University of Tübingen

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Reposted by Cluster of Excellence CMFI

Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · Jul 16

It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...

www.nature.com

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Reposted by Cluster of Excellence CMFI

Anne Grießhammer @ghammeranne.bsky.social · Jul 17

Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health

www.nature.com/articles/s41...

Non-antibiotics disrupt colonization resistance against enteropathogens - Nature

Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.

www.nature.com

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Cluster of Excellence CMFI @cmfi.bsky.social · Jul 17

Unexpected side-effect: how common medications clear the way for pathogens

CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.

Press release: www.cmfi.uni-tuebingen.de/en/news-even...

Scanning electron microscopy image of a gut bacterial community (1:1.000.000). These interacting microorganisms form an ecosystem that is vital to human health. Medications can severely disrupt this fragile balance – they eliminate beneficial bacteria and thereby promote the growth of harmful species.
Image produced by the Maier Lab (Lisa Maier, Anne Grießhammer, Leonardo Boldt) together with the Tübingen Structural Microscopy Core Facility (Michaela Wilsch-Bräuninger, Stefan Fischer); Colouring: Elke Neudert.

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Reposted by Cluster of Excellence CMFI

Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · Jul 16

This is work of many years and many wonderful people! 🧑‍🔬

Led by Anne Grießhammer @ghammeranne.bsky.social and me at the Maier lab @lisamaierlab.bsky.social in Tübingen @cmfi.bsky.social. Read the TL;DR and how the project and Lisa's lab grew hand in hand here: go.nature.com/3Ix8lu3

Research Communities by Springer Nature

Research Communities by Springer Nature provide a forum for all those interested in research to share the latest discoveries, news, and opinions.

go.nature.com

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Cluster of Excellence CMFI @cmfi.bsky.social · Jun 30

🚨 Naming Challenge:
Help redefine the #glycopeptide family!

🏆Submit your idea & win 500 € + authorship credit

Let’s rethink antibiotic classification—together!

🧬 Deadline: Sept 15, 2025

👉 docs.google.com/forms/d/e/1F...

@nadineziemert.bsky.social #NameChallenge #NaturalProducts #Antibiotics

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Cluster of Excellence CMFI @cmfi.bsky.social · Jun 27

They are fundamental to how we understand, maintain, and restore health.

More about CMFI's microbiome researchers:
www.cmfi.uni-tuebingen.de/en/

#CMFI #Microbiome #MicrobesMatter #HumanHealth #MicrobiomeResearch #GutHealth #LifeScience #ScienceCommunication @apcmicrobiomeirel.bsky.social

CMFI - Cluster of Excellence - Controlling Microbes to Fight Infections

The CMFI is one of more than 50 Clusters of Excellence funded by the German federal and state governments as part of the Excellence Initiative. We develop new strategies to control microbial mechanism...

www.cmfi.uni-tuebingen.de

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Cluster of Excellence CMFI @cmfi.bsky.social · Jun 27

𝗠𝗶𝗰𝗿𝗼𝗯𝗲𝘀: 𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀 𝗶𝗻 𝗵𝘂𝗺𝗮𝗻 𝗵𝗲𝗮𝗹𝘁𝗵

The human microbiome—comprising trillions of microorganisms—interacts closely with our immune, metabolic, and nervous systems. It influences directly our health.

On #WorldMicrobiomeDay, we celebrate the science that shows how much Microbes Matter.

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Reposted by Cluster of Excellence CMFI

Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Jun 19

Big thanks to scientific writer Libera Lo Presti for this great little piece on our recent work exploring how proton pump inhibitors (PPIs) and pH affect human gut microbes.
Check it out here: go.nature.com/4lf6jNk

The pill that might be relieving your heartburn but killing your gut microbes

Why drugs commonly used against heartburn harm your gut microbiome

go.nature.com

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Reposted by Cluster of Excellence CMFI

Universität Tübingen @unituebingen.bsky.social · May 26

Die @unituebingen feiert Erfolg im Exzellencluster-Wettbewerb 🎉Freude und Jubel bei der Pressekonferenz zur Entscheidung der DFG am 22.05.25 mit gut 200 Gästen. Weitere Infos und Fotos gibt es online 👉 uni-tuebingen.de/universitaet... @cmfi.bsky.social @ml4science.bsky.social

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Reposted by Cluster of Excellence CMFI

Universität Tübingen @unituebingen.bsky.social · May 22

Die Universität Tübingen erhält sechs #Exzellenzcluster, die im Rahmen der #Exzellenzstrategie vom 01.01.2026 an sieben Jahre lang gefördert werden! Darunter drei Cluster, die bereits etabliert sind und eine erneute Förderung erhalten. uni-tuebingen.de/universitaet... #ExStra #Forschung #UniTübingen

Das Bild zeigt einen Brunnen vor der Neuen Aula. Darunter der Text: Sechs Exzellenzcluster werden in Tübingen gefördert.

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Reposted by Cluster of Excellence CMFI

Nadine Ziemert @nadineziemert.bsky.social · May 22

We were gathering together this evening to hear the announcement of the new clusters of excellence by the German research foundation. So happy to hear that @cmfi.bsky.social gets another round! Love the Team! #naturalproducts #fightinfections #secmet

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Reposted by Cluster of Excellence CMFI

Andreas Peschel @andreaspeschel.bsky.social · May 22

Yeah! 7 more years for @cmfi.bsky.social
So many people to thank... We are a fantastic team!

Cluster of Excellence CMFI @cmfi.bsky.social · May 22

🎉 Fantastic News 🎉

Our CMFI Cluster of Excellence @unituebingen.bsky.social receives funding extension for the next seven years.

Spokesperson Andreas Peschel @andreaspeschel.bsky.social: "We can now advance our research into resistance mechanisms and new antimicrobial agents!"

shorturl.at/rcK1A

CMFI Enters Second Funding Period | CMFI News

The members of CMFI can breathe a sigh of relief: On January 1, 2026, the Tübingen Cluster of Excellence will enter its second funding period with a duration of seven years. This was announced by the ...

www.cmfi.uni-tuebingen.de

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Cluster of Excellence CMFI @cmfi.bsky.social · May 22

🎉 Fantastic News 🎉

Our CMFI Cluster of Excellence @unituebingen.bsky.social receives funding extension for the next seven years.

Spokesperson Andreas Peschel @andreaspeschel.bsky.social: "We can now advance our research into resistance mechanisms and new antimicrobial agents!"

shorturl.at/rcK1A

CMFI Enters Second Funding Period | CMFI News

The members of CMFI can breathe a sigh of relief: On January 1, 2026, the Tübingen Cluster of Excellence will enter its second funding period with a duration of seven years. This was announced by the ...

www.cmfi.uni-tuebingen.de

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Reposted by Cluster of Excellence CMFI

Oliver Bossdorf @bossdorf.bsky.social · May 8

After her excellent PhD defense, Maryam Mahmoudi goes on a ride with her supervisor Eric Kemen. Check out her work about temp variation in plant microbiota: doi.org/10.1093/isme... doi.org/10.1128/mbio...
More to come soon!
@zmbp-tuebingen.bsky.social
@cmfi.bsky.social
@unituebingen.bsky.social

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Reposted by Cluster of Excellence CMFI

Andreas Peschel @andreaspeschel.bsky.social · May 19

Join us in Tubingen as a Junior Research Group Leader if you do research on #ESKAPE pathogens and infections and are interested in the highly cooperative environment of @dzif.bsky.social‬ and @cmfi.bsky.social ! Please send your application or forward to colleagues!
uni-tuebingen.de/universitaet...

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Reposted by Cluster of Excellence CMFI

simonheilbronner.bsky.social @simonheilbronner.bsky.social · May 7

I am happy to share our latest preprint, spearheaded by Laura Camus. We show that tyrosin-dependent interactions can foster integration of S. aureus into the nasal microbiome. @cmfi.bsky.social @lmumuenchen.bsky.social
www.biorxiv.org/content/10.1...

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Reposted by Cluster of Excellence CMFI

Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Apr 30

Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...

Thomas Clavel @tclavel.bsky.social · Apr 29

Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research

Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

rdcu.be

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Cluster of Excellence CMFI @cmfi.bsky.social · Apr 17

Spotify open.spotify.com/show/28niz6p...

Apple Podcasts podcasts.apple.com/us/podcast/i...

Audible www.audible.de/podcast/Insi...

Amazon Music music.amazon.com/podcasts/75b...

YouTube www.youtube.com/playlist?lis...

Podbean insidecmfi.podbean.com

@unituebingen.bsky.social

@dfg.de

open.spotify.com

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Cluster of Excellence CMFI @cmfi.bsky.social · Apr 17

#Podcast Release!

🎙️Folge 4: 𝗗𝗮𝘀 𝗠𝗮𝗹𝗶𝗴𝗻𝗼𝗺 𝘂𝗻𝗱 𝗱𝗮𝘀 𝗠𝗶𝗸𝗿𝗼𝗯𝗶𝗼𝗺

🦠Wirkt sich das Mikrobiom auf die Krebsentstehung aus?

🧪🚨Ja, sagt Christoph Stein-Thoeringer. Ziel seiner Forschung sind personalisierte Medikamente gegen Darmkrebs oder Bauchspeicheldrüsenkrebs.

open.spotify.com/episode/62hK...

Folge 4: Das Malignom und das Mikrobiom

Inside CMFI: Potenziale der Mikrobiomforschung · Episode

open.spotify.com

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