Beyond the commonly considered factor of diet, small-molecule drugs have been identified as effectors of microbiota composition. Recently, two studies (Grießhammer et al. and Kumar et al.) reported that non-antibiotics, like antibiotics, could disrupt gut microbial homeostasis, reducing colonization resistance and facilitating pathogen invasion. These findings hold profound implications for our understanding of drug–host–microbiome interactions.

Metalog is a repository of manually annotated metadata (or contextual data) for metagenomic sequencing data from across the globe.

Noteworthy — It's allergy season. To assuage your discomfort, your physician prescribes a long-term treatment with an antihistamine. Feeling much better, you go out to enjoy some of your favorite stre...

Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.

Some human-targeted drugs can alter gut microbes, creating a favorable environment for pathogens like Salmonella to thrive.

Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

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Nature Communications - Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels,...

Nature - Some non-antibiotic drugs have been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Athanasios Typas and colleagues screened more than...