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Reposted by Jan Homolak

Cluster of Excellence CMFI @cmfi.bsky.social · Jul 17

Unexpected side-effect: how common medications clear the way for pathogens

CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.

Press release: www.cmfi.uni-tuebingen.de/en/news-even...

Scanning electron microscopy image of a gut bacterial community (1:1.000.000). These interacting microorganisms form an ecosystem that is vital to human health. Medications can severely disrupt this fragile balance – they eliminate beneficial bacteria and thereby promote the growth of harmful species.
Image produced by the Maier Lab (Lisa Maier, Anne Grießhammer, Leonardo Boldt) together with the Tübingen Structural Microscopy Core Facility (Michaela Wilsch-Bräuninger, Stefan Fischer); Colouring: Elke Neudert.

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Kiran R. Patil @kiranrpatil.bsky.social · Jul 17

Another fantastic study from @lisamaierlab.bsky.social showing how non-antibiotics impact gut ecosytem. Congratulations @ghammeranne.bsky.social et al.!

Anne Grießhammer @ghammeranne.bsky.social · Jul 17

Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health

www.nature.com/articles/s41...

Non-antibiotics disrupt colonization resistance against enteropathogens - Nature

Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.

www.nature.com

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Reposted by Jan Homolak

Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Jul 16

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

Non-antibiotics disrupt colonization resistance against enteropathogens

Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

rdcu.be

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Jacobo de la Cuesta-Zuluaga @jdlcz.bsky.social · Jul 16

It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...

www.nature.com

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MRC Toxicology Unit @mrc-tu.bsky.social · Jun 30

Stephan Kamrad and Tara Davis in the Patil lab at the MRC Toxicology Unit have identified that some drugs and environmental contaminants alter gut bacterial amine metabolism.

Find out more here: buff.ly/5akzsgs
@kiranrpatil.bsky.social @skamrad.bsky.social

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Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Jul 1

Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

www.nature.com

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Reposted by Jan Homolak

Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Apr 13

🎓 Big milestone for our lab — our very first PhD is finished! Huge congratulations to @ghammeranne.bsky.social for an incredibly impressive piece of work. We are so proud of you and can’t wait to see what you’ll do next. 💫 #PhD #proudPI

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Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Jun 5

What timing! 🎉 Lab member Julia’s first first-author paper got accepted just 8 minutes before her PhD defense started! Huge congrats on a successful PhD and an impressive defense! 🥳📚 #AcademicLife #PhDDefense #TimingIsEverything

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Tami Lieberman @contaminatedsci.bsky.social · May 1

Do people in the same household share strains when they have the same species?

How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?

We answer these and related questions for the facial skin microbiome in our latest paper.

🧵[1/10]

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Jan Homolak @janhomolak.bsky.social · Apr 5

Thanks for sharing @drpaulwicks.bsky.social I think next time we also have to bring cheese! (-:

Paul Wicks, PhD. @drpaulwicks.bsky.social · Apr 2

A novel take on #betterposter at #adpd2025 - turn your preclinical experimentation into an AI generated comic strip! Truly novel scicomms approach from this Croatian team! 🧀

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Reposted by Jan Homolak

Annika Hausmann @hausmannannika.bsky.social · Mar 23

I am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social

👉🏼 rdcu.be/eelLn

Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

Nature Communications - Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels,...

rdcu.be

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Brochado Lab @brochadolab.bsky.social · Feb 20

Brochado and Maier labs in Germany are looking for a PhD student to study horizontal gene transfer in bacteria. ENDAMR Marie Curie doctoral network (endamr.eu) - an amazing opportunity to work with top scientists in the field all around Europe!
www.cmfi.uni-tuebingen.de/mariecuriephd

endamr.eu

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Nature Microbiology @natmicrobiol.nature.com · Feb 3

OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome

@harriswang.bsky.social & co

www.nature.com/articles/s41...

SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology

Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

www.nature.com

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Jan Homolak @janhomolak.bsky.social · Jan 16

www.science.org/doi/10.1126/...
Crazy

Simulating 500 million years of evolution with a language model

More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...

www.science.org

Jan Homolak @janhomolak.bsky.social · Dec 14

@skyview.social unroll

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Guillaume Méric @gmeric.bsky.social · Dec 13

How intriguing and interesting! Here, authors suggest that Microviridae phages, particularly Gokushovirus WZ-2015a, are linked to obesity and food addiction variables in humans from multiple cohorts, with a direct suggested link to serotonin and dopamine metabolism.
www.nature.com/articles/s42...

Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways - Nature Metabolism

Castells-Nobau et al. provide insight into how bacteriophages in the gut microbiome contribute to regulating food addiction by modulating tryptophan and tyrosine metabolism in the host.

www.nature.com

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Anthony Berndt @anthonyberndt.bsky.social · Dec 12

So at the beginning of my postdoc I struggled to amplify Chlamy genes (easily 75%+ GC) and did pretty much the same comparison and found the same results

DMSO= helps but kills pol processivity
Betaine= Lots of spurious products
1,2-propandiol= processivity retained and usually specific product

Sebastian S. Cocioba @atinygreencell.bsky.social · Dec 11

RESULTS

Gel order:
Upstream homology arm, downstream homology arm, full length locus with target gene in middle, a not so great detection primer set. Ladders are NEB 1KB Plus. Arms 1kbp. Full locus 2880bp. All amplified in same conditions.

10/n

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Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Nature Portfolio @natureportfolio.nature.com · Dec 7

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

This is figure 4, which shows collateral sensitivity and cross-resistance interactions between and within antibiotic classes.

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Jan Homolak @janhomolak.bsky.social · Dec 4

I love the fact that Google+ is still here 🥲

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Altmetric @altmetric.com · Dec 4

The Rise of Skywalkers

Altmetric cumulative attention shown by day in the Altmetric Explorers. The Sky Blue section from Bluesky is growing over time.

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Jatin Nagpal @jatinnagpal.bsky.social · Nov 22

Pulled together this starter pack for Microbiota-Gut-Brain Axis Research.
🧠🦠🥼

Hope it is helpful for the people joining in here and nucleating a community.

May have missed people, please leave a reply and I can then add to the pack.

Cheers.

go.bsky.app/PZhXP7R

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Bork Group at EMBL Heidelberg @borklab.bsky.social · Dec 3

In a great collaboration with @typaslab.bsky.social, @lisamaierlab.bsky.social and @biocs.bsky.social found that 24% of the tested human-targeted drugs inhibit the growth of gut commensal bacteria.

"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...

Extensive impact of non-antibiotic drugs on human gut bacteria

Nature - Some non-antibiotic drugs have been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Athanasios Typas and colleagues screened more than...

www.nature.com

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Reposted by Jan Homolak

Typas Lab @typaslab.bsky.social · Dec 2

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...

www.nature.com

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Micah G. Allen @micahgallen.com · Dec 2

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

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