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corrylab.bsky.social @corrylab.bsky.social · 23d

Great to see this paper with @elainetao.bsky.social out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated channel superfamily members #ionchannel #AI #StructuralBiology

www.sciencedirect.com/science/arti...

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Reposted

Lorne Proteins @lorneproteins.bsky.social · Jul 25

📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org

A cartoon image of a beach with a banner that reads "save the date!" 8th-12th February, 2026, Victoria, Australia. Lorne Proteins 2026.

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corrylab.bsky.social @corrylab.bsky.social · Jul 27

2 yrs ago @yiechanglin.bsky.social sent me this movie of lipid scrambling by OSCA1.2. Now we show it’s common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @charlesdcox.bsky.social &Zhang lab. tiny.cc/tmem63

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corrylab.bsky.social @corrylab.bsky.social · Jul 19

Applications for this position are closing tomorrow! Get yours in quickly 😁

corrylab.bsky.social @corrylab.bsky.social · Jun 17

🌟 We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids 🌟

Join us at #scienceanu with amazing collaborators and great working conditions!

Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!

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corrylab.bsky.social @corrylab.bsky.social · Jun 17

🌟 We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids 🌟

Join us at #scienceanu with amazing collaborators and great working conditions!

Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!

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corrylab.bsky.social @corrylab.bsky.social · Mar 27

We show where chloroquine and peptides bind and help explain the polyspecific transport mechanism (2/2)

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corrylab.bsky.social @corrylab.bsky.social · Mar 27

Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2)

tiny.cc/PfCRT

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corrylab.bsky.social @corrylab.bsky.social · Mar 17

Also bittersweet to announce the final work of @elainetao.bsky.social in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members 🤩 we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao & are so proud of you 🎩
tiny.cc/VSD-AF2

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corrylab.bsky.social @corrylab.bsky.social · Mar 17

Bittersweet to announce the wonderful YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin 🤩

YC Lin @yiechanglin.bsky.social · Mar 17

1/ In my final project as part of the @corrylab.bsky.social, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations..

www.biorxiv.org/content/10.1101/2025.03.12.642747v1

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corrylab.bsky.social @corrylab.bsky.social · Mar 16

Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀)
tiny.cc/oligomers

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corrylab.bsky.social @corrylab.bsky.social · Mar 14

Big congratulations to the very sharp @elainetao.bsky.social who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @scienceanu.bsky.social 🔪🎆👩‍🔬👩‍🎓

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corrylab.bsky.social @corrylab.bsky.social · Feb 28

Surely having the majority of grants lasting only 2 years creates a greater workload and less certainty 😬

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Reposted

Lorne Proteins @lorneproteins.bsky.social · Feb 10

Anders ECR session Ruitao Jin: plant Ca ion channels. Mechanical gating of OSCA channels. 100s of subtypes sense and react to physical forces. Homodimers with protomer pore and cleft. Liposome inside-in structure. Membrane belt-MD avg position of lipid head group. Contribute to ion selectivity 🤩

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corrylab.bsky.social @corrylab.bsky.social · Feb 10

Big congratulations to @riottowow.bsky.social .bsky.social for winning an Anders Early Career Award at @lorneproteins.bsky.social ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel. #lorneproteins2025

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corrylab.bsky.social @corrylab.bsky.social · Jan 21

Read more about XPR1 here! www.biorxiv.org/content/10.1...

KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

XPR1 is emerging as the only known inorganic phosphate (Pi) exporter in humans, critical for Pi homeostasis, with its activity stimulated by inositol pyrophosphate InsP8 and regulated by neuronal scaf...

www.biorxiv.org

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corrylab.bsky.social @corrylab.bsky.social · Jan 21

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵

💻 by @ciarawallis.bsky.social & @riottowow.bsky.social

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corrylab.bsky.social @corrylab.bsky.social · Jan 21

Excited to be going to #bps2025 in LA!

Channels, Receptors & Transporters Subgroup of BPS @bpscrt.bsky.social · Jan 19

The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!

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corrylab.bsky.social @corrylab.bsky.social · Jan 8

I should have included one of the nice figures from the paper!
rupress.org/jgp/article-...

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corrylab.bsky.social @corrylab.bsky.social · Jan 8

Excited to start the year with this paper with
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the

hubs.la

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corrylab.bsky.social @corrylab.bsky.social · Dec 18

Season's Greetings from our (lab) family to yours! P.s. can you guess which lab member is which?? 🎄🎅🍪

Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social ♥️

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Reposted

Drew Berry wehi.tv @drewberry.bsky.social · Dec 4

Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs

DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

YouTube video by WEHImovies

youtu.be

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corrylab.bsky.social @corrylab.bsky.social · Dec 1

Great start pack. Are you able to add us as well. Very interested to connect with this group

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ARC Tracker @arc-tracker.bsky.social · Nov 29

We’ve had nearly 3 years of review, review, review.

We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.

This was true 3 years ago. Still true now.

By @drjr.bsky.social

Falling enrolments and funding cuts force Australian universities to take stock

The Australian Universities Accord offers a roadmap for reform, but there are major challenges ahead.

www.nature.com

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corrylab.bsky.social @corrylab.bsky.social · Nov 29

Can you add us to your starter pack? Interested in all kinds of transporters especially those in the malaria parasite

Reposted

Steve Brohawn @stevebrohawn.bsky.social · Nov 27

Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern
#IonChannel #cryoem
www.biorxiv.org/content/10.1...

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