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YC Lin

@yiechanglin.bsky.social

840 followers 810 following 22 posts

Boya Postdoctoral Fellow @PKU | formally @corrylab.bsky.social, ANU MD simulations of lipids and membrane proteins Like PIP2, I am negatively charged in the head

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YC Lin @yiechanglin.bsky.social · Mar 17

1/ In my final project as part of the @corrylab.bsky.social, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations..

www.biorxiv.org/content/10.1101/2025.03.12.642747v1

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Reposted by YC Lin

Augustinas Silale @augustsilale.bsky.social · 6d

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

doi.org

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Our ANU @ouranu.bsky.social · 6d

“In a research paper from the @australiainstitute.org.au called *Cooking the books at the Australian National University*, David Richardson and @richarddenniss.bsky.social said the ANU's argument about its unhealthy financial position was "flimsy".”

www.canberratimes.com.au/story/907948...

'Cooking the books': national think tank questions ANU finances

'They should make clear how they use such donations.'

www.canberratimes.com.au

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Lucas Farnung @lucas.farnunglab.com · 9d

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

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Biophysical Society @biophysicalsoc.bsky.social · 14d

Elizabeth Hinde and Jorge Alegre-Cebollada to Receive 2026 Michael and Kate Bárány Award buff.ly/n6RrjdO

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Edward T Eng @edwardteng.bsky.social · 15d

Join us for the next CryoEM Current Practices Webinar on 9/25/2025 at 12 PM ET / 9 AM PT with Dr. Sarah Clark who will sharing her research on the "Architecture of a Bridge-like Lipid Transfer Protein."

Register here:
us02web.zoom.us/webinar/regi...

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Pedro Leão @pedroleao.bsky.social · 17d

open.substack.com/pub/leaopel/...

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Fabian Munder @fabianmunder.bsky.social · 16d

Check out our preprint in which we determine how a class of potent protein antibiotics specifically kill P. aeruginosa without a need to enter the cell.

doi.org/10.1101/2025...

This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

doi.org

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Oded Rechavi @odedrechavi.bsky.social · 19d

Only single cell sequencing of the all these post docs will reveal why

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Journal of Cell Biology @jcb.org · 20d

Lipid droplets: Open questions and conceptual advances around a unique organelle. New review from Mike Henne (@hennelab.bsky.social), Emma Reynolds, and William: rupress.org/jcb/article/...

#Biochemistry #CellMetabolism #LipidDroplets

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YC Lin @yiechanglin.bsky.social · 20d

congratulations on a super cool study!!

Reposted by YC Lin

PlessLab @plesslab.bsky.social · 21d

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...

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Henry C. Henson @henrychenson.bsky.social · 22d

Writing this piece for Science AAAS gave me a chance to pause and think about what truly matters - to me as a scientist and as a person. If you’re curious, I share my journey of building a new life overseas and the lessons it brought.

www.science.org/content/arti...

I thought science hinged on prestige. Moving abroad made me reassess my priorities

In Denmark, this Ph.D. student fell in love with an egalitarian society that values work-life balance

www.science.org

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eLife @elife.bsky.social · 22d

Stability vs flexibility: reshaping archaeal membranes in silico

This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
buff.ly/jCnRfkO

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Allister Crow @allistercrow.bsky.social · 22d

Delighted that our FtsEX-EnvC paper is now live at mBio!

FtsEX-EnvC is a bacterial Type VII ABC transporter that activates key periplasmic enzymes during cell division.

We found mutations that disrupt FtsEX-EnvC activity and a disulfide that leaves it permanently active.

doi.org/10.1128/mbio...

Diagram of the FtsEX-EnvC mechanism. From Cook & Crow 2025 mBio.

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Ed Twomey @cryoet.bsky.social · 22d

🚨🧠🔬 A major breakthrough in molecular neuroscience:

I am excited to share a new story from our lab, published in accelerated format today by @nature.com:

"Delta-type glutamate receptors are ligand-gated ion channels"

Read more here (free article link): rdcu.be/eGIKz

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YC Lin @yiechanglin.bsky.social · 26d

extremely cool!!!!

Krishna Reddy @krishnareddy.bsky.social · 26d

1/14
Happy (but mostly relieved) to share my dream project with @boudkerlab.bsky.social, now published in @natsmb.nature.com! We used evolution, protein engineering & cryoEM to uncover how ion coupling in glutamate transporters works, and how it evolved.🧵
Free article: go.nature.com/4oRUC1q

Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters - Nature Structural & Molecular Biology

Reddy et al. used ancestral protein reconstruction, cryo-electron microscopy and functional assays to elucidate how a secondary active transporter evolved to harness the energy of sodium gradients to ...

go.nature.com

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Oded Rechavi @odedrechavi.bsky.social · 27d

Second author asking the PI to be co-first

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Vincent J Lynch 🐘🦣🦥 🦇🐋🐢🐍 @devoevomed.bsky.social · 28d

Seriously, not every paper needs to be an epic novel, modeled on Anna Karenina...

www.embopress.org/doi/full/10....

Brief but not bland | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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Hank Green @hankgreen.bsky.social · 28d

Ultramarathons being a Group 1 carcinogen would be so freaking weird. www.nytimes.com/2025/08/19/h...

Are Marathons and Extreme Running Linked to Colon Cancer?

www.nytimes.com

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James Fraser @fraserlab.com · Sep 8

Why hasn't Preprint Peer Review caught on more?

I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.

more in thread below!

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Erdinc Sezgin @sciezgin.bsky.social · Sep 8

Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...

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WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · Sep 3

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.

🔗 www.wehi.edu.au/news/eureka-...

📸 L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova.

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eLife @elife.bsky.social · Sep 4

Membrane Biology: Nothing can replace polyunsaturated lipids

Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/O6hUXFG

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Mark O. Martin @markowenmartin.bsky.social · Sep 4

Here is a demonstration of ice nucleation protein made by Pseudomonas syringe in my #Bio350 #Micronauts in my #Microbiology course at @univpugetsound @ASMicrobiology

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CompBioPhys @compbiophys.bsky.social · Sep 2

📢 We are hiring #PhD students and #Postdocs at the
@mpi-nat.bsky.social in
in the Department of Theoretical and Computational #Biophysics in Göttingen 🇩🇪! 🔗 check our current job adverts at www.mpinat.mpg.de/grubmueller and find your project. Submit your #application today! #job

Helmut Grubmüller

www.mpinat.mpg.de

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