cryo-em.bsky.social
@cryo-em.bsky.social
Reposted by cryo-em.bsky.social
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
December 19, 2025 at 4:45 PM
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Reposted by cryo-em.bsky.social
Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii pubmed.ncbi.nlm.nih.gov/41421337/ #cryoem
December 21, 2025 at 11:30 PM
Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii pubmed.ncbi.nlm.nih.gov/41421337/ #cryoem
Reposted by cryo-em.bsky.social
We’re excited to open applications for Cryo-EM in Structural Biology 2026, part of the Wellcome/MRC-funded national cryo-EM training programme! ❄️
🗓️ Registration is open until 12 January 2026
All the details (and the registration link) are can be found here: astbury.leeds.ac.uk/facilities/w...
🗓️ Registration is open until 12 January 2026
All the details (and the registration link) are can be found here: astbury.leeds.ac.uk/facilities/w...
Cryo-EM in Structural Biology March 2026 : The Astbury Centre for Structural Molecular Biology - "Understanding Life in Molecular Detail"
Course details Course dates: March 2-6th 2026 Format: Hybrid (online lectures and in-person hands-on training) Registration (Deadline January 12th January 2026) Training leads: Meet the trainers Cours...
astbury.leeds.ac.uk
December 19, 2025 at 12:39 PM
We’re excited to open applications for Cryo-EM in Structural Biology 2026, part of the Wellcome/MRC-funded national cryo-EM training programme! ❄️
🗓️ Registration is open until 12 January 2026
All the details (and the registration link) are can be found here: astbury.leeds.ac.uk/facilities/w...
🗓️ Registration is open until 12 January 2026
All the details (and the registration link) are can be found here: astbury.leeds.ac.uk/facilities/w...
Reposted by cryo-em.bsky.social
CryoSift is a platform-independent convolutional neural network tool for assessing the quality of 2D averages to enable the automatic selection of suitable particles for high-resolution reconstructions #Automation #DataProcessing #CryoEM doi.org/10.1107/S205...
December 18, 2025 at 3:32 PM
CryoSift is a platform-independent convolutional neural network tool for assessing the quality of 2D averages to enable the automatic selection of suitable particles for high-resolution reconstructions #Automation #DataProcessing #CryoEM doi.org/10.1107/S205...
Reposted by cryo-em.bsky.social
From our software team - #SmartEPU Software v3.14 for #SingleParticleAnalysis. This release gives #cryoEM researchers faster workflows and smarter automation with CryoFlow 2.0. See it in action. ter.li/gfdmj7
December 17, 2025 at 7:18 PM
From our software team - #SmartEPU Software v3.14 for #SingleParticleAnalysis. This release gives #cryoEM researchers faster workflows and smarter automation with CryoFlow 2.0. See it in action. ter.li/gfdmj7
Reposted by cryo-em.bsky.social
Deep learning-based postprocessing and model building for cryo-electron microscopy maps pubmed.ncbi.nlm.nih.gov/41401630/ #cryoem
December 17, 2025 at 11:30 PM
Deep learning-based postprocessing and model building for cryo-electron microscopy maps pubmed.ncbi.nlm.nih.gov/41401630/ #cryoem
1.5Å structure of aldolase (150 kDa) from Thermo Fisher's new Krios 5
www.emdataresource.org/EMD-74336
www.emdataresource.org/EMD-74336
EMDataResource
www.emdataresource.org
December 17, 2025 at 3:48 AM
1.5Å structure of aldolase (150 kDa) from Thermo Fisher's new Krios 5
www.emdataresource.org/EMD-74336
www.emdataresource.org/EMD-74336
Reposted by cryo-em.bsky.social
A quick tutorial on the DAQ structure validation score for protein models derived from cryo-EM. DAQ evaluates amino acid–level accuracy in your model. Consider including a DAQ validation report in your next publication!
www.youtube.com/watch?v=YRAT...
www.youtube.com/watch?v=YRAT...
DAQ-Score: Automatic AI-based Cryo-EM Structure Model Validation!
YouTube video by Kihara Bioinformatics Lab
www.youtube.com
December 14, 2025 at 8:44 PM
A quick tutorial on the DAQ structure validation score for protein models derived from cryo-EM. DAQ evaluates amino acid–level accuracy in your model. Consider including a DAQ validation report in your next publication!
www.youtube.com/watch?v=YRAT...
www.youtube.com/watch?v=YRAT...
Reposted by cryo-em.bsky.social
December Update of DAQ-Score DB! Quality evaluations of protein models from cryo-EM. Now includes evaluation of 258,956 protein chains.
Check at daqdb.kiharalab.org
It's very easy to compute DAQ for your protein model. Add the validation result in your publication: em.kiharalab.org/algorithm/da...
Check at daqdb.kiharalab.org
It's very easy to compute DAQ for your protein model. Add the validation result in your publication: em.kiharalab.org/algorithm/da...
December 13, 2025 at 2:15 PM
December Update of DAQ-Score DB! Quality evaluations of protein models from cryo-EM. Now includes evaluation of 258,956 protein chains.
Check at daqdb.kiharalab.org
It's very easy to compute DAQ for your protein model. Add the validation result in your publication: em.kiharalab.org/algorithm/da...
Check at daqdb.kiharalab.org
It's very easy to compute DAQ for your protein model. Add the validation result in your publication: em.kiharalab.org/algorithm/da...
Reposted by cryo-em.bsky.social
IsoNet2 determines cellular structures at submolecular resolution without averaging www.biorxiv.org/content/10.64898/2025.12.09.693325v1 #cryoem
December 12, 2025 at 11:42 AM
IsoNet2 determines cellular structures at submolecular resolution without averaging www.biorxiv.org/content/10.64898/2025.12.09.693325v1 #cryoem
Reposted by cryo-em.bsky.social
An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoem
December 11, 2025 at 9:16 AM
An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoem
Reposted by cryo-em.bsky.social
Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
December 10, 2025 at 11:02 AM
Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪
Reposted by cryo-em.bsky.social
ICYMI: New online: EMProt improves structure determination from cryo-EM maps
EMProt improves structure determination from cryo-EM maps
Nature Structural & Molecular Biology, Published online: 08 December 2025; doi:10.1038/s41594-025-01723-1Here the authors present an artificial-intelligence-based automated method for improved protein structure determination from cryo-EM density maps by efficiently integrating map information and structure prediction.
go.nature.com
December 10, 2025 at 8:56 AM
ICYMI: New online: EMProt improves structure determination from cryo-EM maps
Reposted by cryo-em.bsky.social
Editorial: Breakthroughs in Cryo-EM with machine learning and artificial intelligence pubmed.ncbi.nlm.nih.gov/41358201/ #cryoem
December 10, 2025 at 12:06 AM
Editorial: Breakthroughs in Cryo-EM with machine learning and artificial intelligence pubmed.ncbi.nlm.nih.gov/41358201/ #cryoem
Reposted by cryo-em.bsky.social
🚨 New blog: GPU-accelerated motion correction
Motion correction remains one of the slowest and most costly steps in #cryoEM workflows. So we rebuilt it from scratch. Our new in-house GPU-accelerated CryoCloud Motion Correction is designed for speed, scale and high throughput.
lnkd.in/eiJgsYgJ
Motion correction remains one of the slowest and most costly steps in #cryoEM workflows. So we rebuilt it from scratch. Our new in-house GPU-accelerated CryoCloud Motion Correction is designed for speed, scale and high throughput.
lnkd.in/eiJgsYgJ
December 9, 2025 at 12:57 PM
🚨 New blog: GPU-accelerated motion correction
Motion correction remains one of the slowest and most costly steps in #cryoEM workflows. So we rebuilt it from scratch. Our new in-house GPU-accelerated CryoCloud Motion Correction is designed for speed, scale and high throughput.
lnkd.in/eiJgsYgJ
Motion correction remains one of the slowest and most costly steps in #cryoEM workflows. So we rebuilt it from scratch. Our new in-house GPU-accelerated CryoCloud Motion Correction is designed for speed, scale and high throughput.
lnkd.in/eiJgsYgJ
Reposted by cryo-em.bsky.social
Visualizing macromolecular machines using cryo-electron microscopy
Dr. Lisa Eshun-Wilson
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/-eXtdcP3O8k?...
Dr. Lisa Eshun-Wilson
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/-eXtdcP3O8k?...
Visualizing macromolecular machines using cryo-electron microscopy
YouTube video by ARC Centre for Cryo-EM of Membrane Proteins
youtu.be
December 9, 2025 at 8:19 AM
Visualizing macromolecular machines using cryo-electron microscopy
Dr. Lisa Eshun-Wilson
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/-eXtdcP3O8k?...
Dr. Lisa Eshun-Wilson
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/-eXtdcP3O8k?...
Reposted by cryo-em.bsky.social
Matthew D. Giammar et al.: Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology ##InSituStructuralBiology##CryoEM##CryoET@usc...##IUCrhttps://journals.iucr.org/paper?S2059798325009982
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology
In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describe Leopard-EM (Location and orientation of particles found using two-dimensional tEmplate Matching), an extensible Python package for 2DTM to accelerate in situ structural biology.
journals.iucr.org
December 9, 2025 at 1:00 AM
Matthew D. Giammar et al.: Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology ##InSituStructuralBiology##CryoEM##CryoET@usc...##IUCrhttps://journals.iucr.org/paper?S2059798325009982
Reposted by cryo-em.bsky.social
Jeffrey Gu, Minkyu Jeon, Ambri Ma, Serena Yeung-Levy, Ellen D. Zhong: CryoHype: Reconstructing a thousand cryo-EM structures with transformer-based hypernetworks https://arxiv.org/abs/2512.06332 https://arxiv.org/pdf/2512.06332 https://arxiv.org/html/2512.06332
December 9, 2025 at 6:30 AM
Jeffrey Gu, Minkyu Jeon, Ambri Ma, Serena Yeung-Levy, Ellen D. Zhong: CryoHype: Reconstructing a thousand cryo-EM structures with transformer-based hypernetworks https://arxiv.org/abs/2512.06332 https://arxiv.org/pdf/2512.06332 https://arxiv.org/html/2512.06332
Reposted by cryo-em.bsky.social
Since submission, we have a new version of the program with some improvements, and we have many developments in the pipeline for faster, more sensitive template matching. Keep an eye on our GitHub for these.
github.com/Lucaslab-Ber...
github.com/Lucaslab-Ber...
GitHub - Lucaslab-Berkeley/Leopard-EM: Two-Dimensional Template Matching implemented in Python
Two-Dimensional Template Matching implemented in Python - Lucaslab-Berkeley/Leopard-EM
github.com
December 8, 2025 at 1:57 PM
Since submission, we have a new version of the program with some improvements, and we have many developments in the pipeline for faster, more sensitive template matching. Keep an eye on our GitHub for these.
github.com/Lucaslab-Ber...
github.com/Lucaslab-Ber...
Reposted by cryo-em.bsky.social
Now out in full form. Again, a big thanks to #teamtomo and @alisterburt.bsky.social for developing the infrastructure to build this on. journals.iucr.org/d/issues/202...
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology
In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describ...
journals.iucr.org
December 8, 2025 at 1:54 PM
Now out in full form. Again, a big thanks to #teamtomo and @alisterburt.bsky.social for developing the infrastructure to build this on. journals.iucr.org/d/issues/202...
Reposted by cryo-em.bsky.social
Mark your calendars for January 13th when our own Alice-Roza Eruera will give a primer on Building CryoET Training Workflows Using the SBGrid Ecosystem.
Register here: buff.ly/AaZQlJL
#SBGrid #Structuralbiology #Webinars
Register here: buff.ly/AaZQlJL
#SBGrid #Structuralbiology #Webinars
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
December 8, 2025 at 5:05 PM
Mark your calendars for January 13th when our own Alice-Roza Eruera will give a primer on Building CryoET Training Workflows Using the SBGrid Ecosystem.
Register here: buff.ly/AaZQlJL
#SBGrid #Structuralbiology #Webinars
Register here: buff.ly/AaZQlJL
#SBGrid #Structuralbiology #Webinars
Reposted by cryo-em.bsky.social
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology pubmed.ncbi.nlm.nih.gov/41355025/ #cryoem
December 8, 2025 at 8:10 AM
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology pubmed.ncbi.nlm.nih.gov/41355025/ #cryoem
Reposted by cryo-em.bsky.social
Just sharing again - don't miss our Webinar on CEMOVIS with a Krios #cryoEM on Tuesday - fantastic insight into both history and recent successes! Register here: ter.li/v0aj7d
Discover a new way to look inside the cell 👀
CEMOVIS (#CryoEM of vitreous sections) involves cutting thin sections with a knife. The result? Serial sections that can cover larger cell areas, helping position FIB-milled lamellae in context.
🔗 Register to join the webinar on 9th Dec ter.li/v0aj7d
CEMOVIS (#CryoEM of vitreous sections) involves cutting thin sections with a knife. The result? Serial sections that can cover larger cell areas, helping position FIB-milled lamellae in context.
🔗 Register to join the webinar on 9th Dec ter.li/v0aj7d
December 5, 2025 at 2:58 PM
Just sharing again - don't miss our Webinar on CEMOVIS with a Krios #cryoEM on Tuesday - fantastic insight into both history and recent successes! Register here: ter.li/v0aj7d
Reposted by cryo-em.bsky.social
Did you know we publish a monthly newsletter? It features Cryo-EM, Crystallography, Beamline and Structural Biology news, information, new product releases and more. Read and subscribe today! zurl.co/glmG #cryoem #crystallography #beamline #structuralbiology
December 5, 2025 at 4:00 PM
Did you know we publish a monthly newsletter? It features Cryo-EM, Crystallography, Beamline and Structural Biology news, information, new product releases and more. Read and subscribe today! zurl.co/glmG #cryoem #crystallography #beamline #structuralbiology
Reposted by cryo-em.bsky.social
Cryo-IEF: a comprehensive foundation model for image processing in single-particle cryo-EM.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A comprehensive foundation model for cryo-EM image processing - Nature Methods
Cryo-IEF is a pre-trained foundation model for performing diverse image-processing tasks in single-particle cryo-EM. CryoWizard, enabled by Cryo-IEF, is a fully automated cryo-EM processing pipeline.
www.nature.com
December 4, 2025 at 8:25 PM
Cryo-IEF: a comprehensive foundation model for image processing in single-particle cryo-EM.
www.nature.com/articles/s41...
www.nature.com/articles/s41...