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Reposted by David Sünderhauf

Craig MacLean @craigmaclean.bsky.social · 9d

New pre-print: Eco-evolutionary responses of phage to different thermal regimes.

Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
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www.biorxiv.org/content/10.1...

Evolutionary rescue accelerates competitive exclusion in a parasite community

Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...

www.biorxiv.org

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David Sünderhauf @davvi36.bsky.social · Sep 8

😂😂

David Sünderhauf @davvi36.bsky.social · Sep 8

I'm just trying to find a plasmid term and now Google's AI thinks I'm having a meltdown over grammar 😭

Googles AI summary: "
"Death by conjugation" is not a literal term but likely refers to the repetitive, overwhelming process of conjugating verbs, particularly verbs that mean "to die""

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Reposted by David Sünderhauf

University of Exeter's Environment and Sustainability Institute @uniofexeteresi.bsky.social · Sep 2

Searching for a PhD in Microbiology? 🦠
Prof Stineke van Houte& @davvi36.bsky.social are looking for a prospective PhD student to start in October 2026 who is excited about bacteria, how they interact, and how they exchange DNA with each other.
Deadline 20.10.25.
gw4biomed.ac.uk/developing-c...

Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP

Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a ...

gw4biomed.ac.uk

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Reposted by David Sünderhauf

Sorek Lab @soreklab.bsky.social · Sep 2

Preprint: De-novo design of proteins that inhibit bacterial defenses

Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications

Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

www.biorxiv.org

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David Sünderhauf @davvi36.bsky.social · Sep 2

PhD opportunity, please share:

We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...

Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP

Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a ...

gw4biomed.ac.uk

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David Sünderhauf @davvi36.bsky.social · Aug 21

looks cool, congrats!

Reposted by David Sünderhauf

Sarah Bigot @sbigot.bsky.social · Aug 20

Our paper “Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli” is now online in @natcomms.nature.com ✨
👉 www.nature.com/articles/s41...
@cnrs-rhoneauvergne.bsky.social @mmsb-lyon.bsky.social

Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli - Nature Communications

pOXA-48 plasmids have emerged as key vectors of carbapenem resistance within Enterobacteriaceae. In this study, the authors use a transposon sequencing (Tn-seq) approach to identify genetic determinan...

www.nature.com

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Reposted by David Sünderhauf

Anne Chevallereau @annechevallereau.bsky.social · Aug 19

#phagesky

I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?

Repost appreciated :)

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David Sünderhauf @davvi36.bsky.social · Aug 13

super nice, looking forward to reading this! congrats all :)

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Reposted by David Sünderhauf

Jorge Sastre Domínguez @jorgesastred.bsky.social · Aug 13

New paper out! 🔈🔈📣📣

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.

Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻

www.biorxiv.org/content/10.1...

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

www.biorxiv.org

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David Sünderhauf @davvi36.bsky.social · Aug 11

This looks super cool & clever, congrats!!

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Reposted by David Sünderhauf

Uli Klümper @ulikluemper.bsky.social · Aug 11

🧬💊Our new paper in @ismepublications.bsky.social🧬💊

"Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance"

In collaboration with @umweltbundesamt.bsky.social

Read the thread below:

academic.oup.com/ismej/advanc...

#AMR

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Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance

Abstract. Selection for antibiotic resistance has been demonstrated at low, environmentally relevant antibiotic concentrations. The concept of minimum sele

academic.oup.com

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David Sünderhauf @davvi36.bsky.social · Aug 8

Phage resistance research position with a fantastic supervisor 👇

Ellinor Alseth @ellinoralseth.bsky.social · Aug 8

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...

Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway

Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025

www.jobbnorge.no

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Reposted by David Sünderhauf

Ellinor Alseth @ellinoralseth.bsky.social · Aug 8

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...

Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway

Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025

www.jobbnorge.no

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David Sünderhauf @davvi36.bsky.social · Aug 6

Congratulations, very happy for you 😁😁

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David Sünderhauf @davvi36.bsky.social · Aug 5

Great, I'll gamble on the exchange rate and pay in EC dollar now 🏝💵 come onnnn November 🤞🏻

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David Sünderhauf @davvi36.bsky.social · Aug 5

Brilliant idea!

Meaghan Castledine @mcastd.bsky.social · Aug 5

Want to name a real virus? I have recently discovered 9 new phages which now need names! To enter, you simply need to donate to the Cystic Fibrosis Trust on my JustGiving page (£2 = 1 entry) and share your email with me on donation (see link info). Please share 💚 www.justgiving.com/page/meaghan-c-1

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Reposted by David Sünderhauf

Meaghan Castledine @mcastd.bsky.social · Aug 5

Want to name a real virus? I have recently discovered 9 new phages which now need names! To enter, you simply need to donate to the Cystic Fibrosis Trust on my JustGiving page (£2 = 1 entry) and share your email with me on donation (see link info). Please share 💚 www.justgiving.com/page/meaghan-c-1

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David Sünderhauf @davvi36.bsky.social · Jul 24

Plasmid leading regions & their contribution to plasmid establishment are all the rage in the plasmid world right now. This review summarizes why 👉 www.sciencedirect.com/science/arti...

Strategies for zygotic gene expression during plasmid establishment

Conjugative plasmids are key drivers of horizontal gene transfer and the spread of antimicrobial resistance. Their successful establishment in new hos…

www.sciencedirect.com

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David Sünderhauf @davvi36.bsky.social · Jul 22

Hopefully this link actually works:
sites.exeter.ac.uk/vanhoutelab/...

2025 Phage Therapy Workshop - Free Event

November 25th, 2025 at the Spine Building in Liverpool Rising levels of antimicrobial resistance threaten healthcare systems and economies worldwide. Phage therapy has proven to be an effective last-r...

sites.exeter.ac.uk

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David Sünderhauf @davvi36.bsky.social · Jul 22

Please share! 🦠
Workshop on Phage Therapy in Liverpool on 25th November organised by Stineke van Houte, @jojofoth.bsky.social, @brockhurstlab.bsky.social, & Edze Westra.

Limited FREE tickets & more info here: sites.exeter.ac.uk/vanhoutelab/...

#MicroSky

Conference flyer, all info is on link too

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David Sünderhauf @davvi36.bsky.social · Jul 17

Looks great, congrats all!

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Reposted by David Sünderhauf

Willem van Schaik @wvschaik.bsky.social · Jul 17

New manuscript from the group

'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'

www.biorxiv.org/content/10.1...

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IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium

pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium , but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of t...

www.biorxiv.org

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David Sünderhauf @davvi36.bsky.social · Jul 16

Congratulations, this looks great! I'll send you an email re antibiotic resistance genes moving onto the chromosome.