Meaghan Castledine
@mcastd.bsky.social
770 followers
200 following
31 posts
Post-doc with Buckling lab 🦠 all things evolution, phage therapy and immune system interactions 🧫🔬 I also have a dog and enjoy nerdy things 🧝🏻♀️
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Meaghan Castledine
@mcastd.bsky.social
· Nov 15
Critically evaluating the relative importance of phage in shaping microbial community composition
The ubiquity of bacteriophages (phages) and the major evolutionary and ecological
impacts they can have on their microbial hosts has resulted in phages often cited
as key drivers shaping microbial com...
www.cell.com
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
David Sünderhauf
@davvi36.bsky.social
· Sep 2
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a ...
gw4biomed.ac.uk
Reposted by Meaghan Castledine
James McInerney
@jomcinerney.bsky.social
· Aug 29
Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes
Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...
www.biorxiv.org
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Tim Barraclough
@timbarra.bsky.social
· Aug 1
Eco-evolutionary robustness of wild bacterial communities to experimental perturbation
Abstract. Most knowledge about bacterial evolution and ecological interactions comes from laboratory studies. One difference between the wild and most labo
academic.oup.com
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Brian D. Wade
@astrobrian.bsky.social
· Jul 21
Experimental evolution in an era of molecular manipulation - Nature Reviews Genetics
In this Review, Ascensao and Desai discuss how methodological advances in genotype and phenotype manipulation are transforming experimental evolution approaches and providing new insights into the und...
www.nature.com
Meaghan Castledine
@mcastd.bsky.social
· Jul 10
Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance
Phage therapy, the use of viruses that infect bacteria (bacteriophages), is a promising complement to antibiotics during the antimicrobial resistance crisis, but treatment success is very variable. Ev...
www.biorxiv.org
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Reposted by Meaghan Castledine
Kat Holt
@katholt.bsky.social
· Jul 1
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could aver...
doi.org