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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · 14d

Alessandro and I discussed this great paper www.science.org/doi/10.1126/... that investigates a deleterious genetic interaction that causes melanoma.

Reposted by Diego Ortega-Del Vecchyo

Fernando Villanea @fervillanea.bsky.social · Aug 21

Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!

This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).

www.science.org/doi/10.1126/...

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection

We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...

www.science.org

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Aug 22

Gaceta UNAM cubrió nuestra investigación sobre el impacto de la selección natural en la predicción genética de rasgos complejos en individuos del pasado:

www.gaceta.unam.mx/la-seleccion...

La selección natural complica las predicciones genéticas - Gaceta UNAM

Hacen menos confiables los análisis de características físicas en humanos antiguos, afirma artículo publicado en la revista científica The American Journal of Human Genetics, en el cual participa un g...

www.gaceta.unam.mx

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Jul 19

Trying something with huitlacoche (such as quesadilla of huitlacoche) is a good and interesting choice. Other good things to try are guacamole as well as "Chile relleno de queso".

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Jul 19

I just saw this message!

Going to one branch of the "El Cardenal" restaurants is a good choice. They have good salads and omelettes. They also have some dishes made with avocado, huitlacoche (corn fungus which is delicious), Poblano (pepper) and cheese.

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Reposted by Diego Ortega-Del Vecchyo

Emily Josephs @emjo.bsky.social · Jun 12

Hey, Miles' @milesroberts.bsky.social beautiful paper showing that sequence diversity missed by standard methods contributes to Lewontin's paradox is officially published in @evolletters.bsky.social. academic.oup.com/evlett/advan...

k-mer-based diversity scales with population size proxies more than nucleotide diversity in a meta-analysis of 98 plant species

Abstract. A key prediction of neutral theory is that the level of genetic diversity in a population should scale with population size. However, as was note

academic.oup.com

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Reposted by Diego Ortega-Del Vecchyo

Arun Durvasula @arundurvasula.bsky.social · Jun 11

Our review of recent Sequentially Markovian Coalescent methods is up on arXiv: arxiv.org/abs/2506.00692 (based on last year's @official-smbe.bsky.social symposium)

Not Just $N_e$ $N_e$-more: New Applications for SMC from Ecology to Phylogenies

Genomes contain the mutational footprint of an organism's evolutionary history, shaped by diverse forces including ecological factors, selective pressures, and life history traits. The sequentially Ma...

arxiv.org

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Jun 10

Happy to have worked on this project with @mashaals.bsky.social , Emilia Huerta-Sanchez and Valeria Añorve-Garibay. We analyzed how stabilizing and directional selection cause problems to predict traits in ancient samples.

Mashaal Sohail @mashaals.bsky.social · Jun 10

Our new work is now out in AJHG "Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples." Great collaboration with @delvecchyo.bsky.social and Emilia Huerta-Sanchez, led by Valeria Añorve-Garibay.

The American Journal of Human Genetics @ajhgnews.bsky.social · Jun 10

📣Online now!
📄Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples
🧑‍🤝‍🧑 @delvecchyo.bsky.social @mashaals.bsky.social & co

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Reposted by Diego Ortega-Del Vecchyo

The American Journal of Human Genetics @ajhgnews.bsky.social · Jun 10

📣Online now!
📄Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples
🧑‍🤝‍🧑 @delvecchyo.bsky.social @mashaals.bsky.social & co

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples

Using polygenic scores, we find that two types of natural selection, stabilizing selection and directional selection, can decrease the prediction accuracy of complex traits in ancient individuals. We ...

www.cell.com

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Reposted by Diego Ortega-Del Vecchyo

Daniela Robles-Espinoza @daniela-oaks.bsky.social · Jan 12

We continue with the #human genetic variation and ancient #genomics session! Our next speaker is @delvecchyo.bsky.social, who is telling us about how to use geographical and temporal information to infer the action of natural #selection @liigh-unam.bsky.social #LIIGH10anniversary

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Reposted by Diego Ortega-Del Vecchyo

Daniela Robles-Espinoza @daniela-oaks.bsky.social · Jan 11

The next talk is by PhD student Alan Izarraras from @delvecchyo.bsky.social's group, and he is telling us about how to infer the distribution of fitness effects using local genealogies @liigh-unam.bsky.social #LIIGH10anniversary

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Reposted by Diego Ortega-Del Vecchyo

Paleogenomics - María Ávila Arcos @paleogenomics.bsky.social · Nov 18

🚨🪅 Registration is NOW OPEN for our Symposium on Ancient Pathogen Genomics! 🦠🧬 Join us on April 12-13 2025 in Juriquilla, Mexico. Featuring top speakers & great science in a beautiful venue! Plz RT !
liigh.unam.mx/apg/ 🪅🚨

Ancient Pathogens Genomics International Symposium

liigh.unam.mx

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Reposted by Diego Ortega-Del Vecchyo

christiandhuber.bsky.social @christiandhuber.bsky.social · Jan 4

genestogenomes.org/digging-up-t...

Digging up the recent past: how effective are genomic tools at deciphering our genetic ancestry?

Researchers evaluate the accuracy of common statistical methods to identify recent genetic ancestry in GENETICS.

genestogenomes.org

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Reposted by Diego Ortega-Del Vecchyo

Ana Ignatieva @anaignatieva.bsky.social · Dec 9

New preprint (with @linoafferreira.bsky.social) where we explore the idea of using genealogies (in the form of ancestral recombination graphs, ARGs) to tell apart real GxG interaction signals between nearby variants from false positives www.biorxiv.org/content/10.1...

Phantom epistasis through the lens of genealogies

Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant (with a purely additive effect on the phenotype) causes the spurious inference o...

www.biorxiv.org

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Dec 6

Hi, I recommend checking out some of the papers and software we cite in our paper. Best of luck!

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Dec 2

Don't forget to submit your abstract for "Probabilistic Modeling in Genomics 2025". Deadline: January 10th, 2025. meetings.cshl.edu/meetings.asp...

Probabilistic Modeling in Genomics

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Nov 17

Ese meme es mi filosofía moral.

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Nov 6

Spending more time here sounds great!

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 30

Thanks, Rebekah! Happy that our paths crossed as some of the last postdocs from Monty.

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 30

I have received tenure! I got here thanks to the support from my students, colleagues, mentors and home institution ( @liigh-unam.bsky.social ). I plan to continue doing research on Theoretical Population Genetics and developing methods to understand how Evolution has shaped our past.

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 12

Natural selection can provoke substantial biases in predicting complex traits from ancient genomes using polygenic scores, so it’s crucial to consider its impact when predicting complex traits! 7/7

Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 12

In addition, our simulations showed that both types of selection can hamper polygenic scores accuracy for traits like height and BMI, despite having complete genotype data and perfect effect size estimates. 6/7

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 12

This leads to a reduction in ancient polygenic scores accuracy for the first, and a reduction that depends on the allele effects for the later. 5/7

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 12

We found that while stabilizing selection accelerates the loss of high-effect alleles, directional selection leads to the loss of alleles that drive phenotypes away from the optimal value. 4/7

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Diego Ortega-Del Vecchyo @delvecchyo.bsky.social · Sep 12

We observed that each type of selection creates a different pattern for the alleles that are lost and conserved through time between ancient and modern individuals. 3/7

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