Edna Ondari
@dnapluse.bsky.social
Reposted by Edna Ondari
Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T
December 19, 2025 at 2:05 PM
Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T
Reposted by Edna Ondari
The grant application to support members attending the Annual Conference 2026 is open and closes on 2 January 2026 at 23:59 GMT. Check your eligibility and apply now: microb.io/AC26Grant #Microbio26
December 19, 2025 at 4:04 PM
The grant application to support members attending the Annual Conference 2026 is open and closes on 2 January 2026 at 23:59 GMT. Check your eligibility and apply now: microb.io/AC26Grant #Microbio26
Reposted by Edna Ondari
Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria. Published Open Access and fee-free in Microbiology using a Publish and Read agreement: doi.org/10.1099/mic.... #MicrobioJ #PublishAndRead
December 19, 2025 at 3:31 PM
Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria. Published Open Access and fee-free in Microbiology using a Publish and Read agreement: doi.org/10.1099/mic.... #MicrobioJ #PublishAndRead
Reposted by Edna Ondari
I am glad to see large media outlets reporting on this. Hopefully it shames the researchers into not continuing with the planned study or at minimum making sure ALL children in the study receive the birth dose of the HepB vaccine.
www.science.org/content/arti...
www.science.org/content/arti...
CDC funds controversial hepatitis B vaccine trial in African newborns
Scientists question the value of the proposed study, which will investigate a vaccine long known to be efficacious and safe
www.science.org
December 19, 2025 at 3:40 PM
I am glad to see large media outlets reporting on this. Hopefully it shames the researchers into not continuing with the planned study or at minimum making sure ALL children in the study receive the birth dose of the HepB vaccine.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Edna Ondari
All living organisms face the problem of parasites - but what happens when DNA has invaded the genome?
go.nature.com/3MDiJCq
go.nature.com/3MDiJCq
SOS: RNA-processing mechanism rescues genes from invasive DNA
Transposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, ‘SOS splicing’, that provides a quick fix.
go.nature.com
December 16, 2025 at 11:34 AM
All living organisms face the problem of parasites - but what happens when DNA has invaded the genome?
go.nature.com/3MDiJCq
go.nature.com/3MDiJCq
Reposted by Edna Ondari
Reposted by Edna Ondari
Sierra Leone diagnoses 500 women with cervical cancer every year. More than 70% don't survive.
Now, in one week one million girls have been protected against it with the HPV vaccine.
Now, in one week one million girls have been protected against it with the HPV vaccine.
December 3, 2025 at 7:00 AM
Sierra Leone diagnoses 500 women with cervical cancer every year. More than 70% don't survive.
Now, in one week one million girls have been protected against it with the HPV vaccine.
Now, in one week one million girls have been protected against it with the HPV vaccine.
Reposted by Edna Ondari
Mathematical modelling of synergistic triple-antibiotic therapy against carbapenem-resistant Acinetobacter baumannii at clinically achievable concentrations. Find out more in JMM: doi.org/10.1099/jmm.... #JMedMicro
December 1, 2025 at 12:02 PM
Mathematical modelling of synergistic triple-antibiotic therapy against carbapenem-resistant Acinetobacter baumannii at clinically achievable concentrations. Find out more in JMM: doi.org/10.1099/jmm.... #JMedMicro
Reposted by Edna Ondari
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
#MicroSky 🦠
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
#MicroSky 🦠
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 26, 2025 at 3:59 PM
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
#MicroSky 🦠
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Edna Ondari
#NewResearch
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
#MicroSky #AMR 🦠 @andresfloto.bsky.social
www.nature.com/articles/s41...
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
#MicroSky #AMR 🦠 @andresfloto.bsky.social
www.nature.com/articles/s41...
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
www.nature.com
November 26, 2025 at 3:54 PM
#NewResearch
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
#MicroSky #AMR 🦠 @andresfloto.bsky.social
www.nature.com/articles/s41...
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
#MicroSky #AMR 🦠 @andresfloto.bsky.social
www.nature.com/articles/s41...
Reposted by Edna Ondari
Thoughtful piece on the importance of "DEI" in health research, published in Time Magazine.
time.com/7333975/dei-...
This presents the case in the context of lupus.
time.com/7333975/dei-...
This presents the case in the context of lupus.
DEI Isn’t Wasteful. It’s Necessary for Good Medicine
Lupus patients pay the price when we erase inclusion from medical research.
time.com
November 19, 2025 at 1:44 PM
Thoughtful piece on the importance of "DEI" in health research, published in Time Magazine.
time.com/7333975/dei-...
This presents the case in the context of lupus.
time.com/7333975/dei-...
This presents the case in the context of lupus.
Reposted by Edna Ondari
Chemists have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens
This discovery suggests a new paradigm for antibiotic discovery through identifying and testing intermediates in the pathways to diverse natural compounds
#SomeGoodNews
This discovery suggests a new paradigm for antibiotic discovery through identifying and testing intermediates in the pathways to diverse natural compounds
#SomeGoodNews
New antibiotic found hiding in plain sight
warwick.ac.uk
November 16, 2025 at 11:12 PM
Chemists have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens
This discovery suggests a new paradigm for antibiotic discovery through identifying and testing intermediates in the pathways to diverse natural compounds
#SomeGoodNews
This discovery suggests a new paradigm for antibiotic discovery through identifying and testing intermediates in the pathways to diverse natural compounds
#SomeGoodNews
November 18, 2025 at 12:41 AM
Reposted by Edna Ondari
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
November 15, 2025 at 12:17 PM
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Reposted by Edna Ondari
Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 10, 2025 at 9:44 AM
Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Edna Ondari
When we understand the story of genomics, we can understand diseases better. This means we can diagnose them quicker, treat them more effectively, and even prevent them. Let's celebrate science!
November 10, 2025 at 12:43 PM
When we understand the story of genomics, we can understand diseases better. This means we can diagnose them quicker, treat them more effectively, and even prevent them. Let's celebrate science!
Reposted by Edna Ondari
This can’t be happening
Canada has lost its measles elimination status after more than 25 years
Canada has lost its measles elimination status after more than 25 years
November 10, 2025 at 2:46 PM
This can’t be happening
Canada has lost its measles elimination status after more than 25 years
Canada has lost its measles elimination status after more than 25 years
Reposted by Edna Ondari
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
www.nature.com
November 5, 2025 at 7:32 AM
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Edna Ondari
As aid dries up in Kenya, millions are threatened by the climate-driven disease kala-azar. grist.org/health/kala-...
As aid dries up in Kenya, millions are threatened by the climate-driven disease kala-azar
Rising temperatures and erratic rainfall have supercharged the breeding of sandflies that spread the climate-driven disease kala-azar.
grist.org
November 5, 2025 at 2:09 PM
As aid dries up in Kenya, millions are threatened by the climate-driven disease kala-azar. grist.org/health/kala-...
