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dr-l-mcculloch.bsky.social
Dr Laura McCulloch
@dr-l-mcculloch.bsky.social
240 followers 380 following 10 posts
Principal investigator at the University of Edinburgh. Research on the systemic immune response to stroke and complications of stroke recovery. #Bcells #infection #GIdysfunction #cognitivedecline Wellcome Sir Henry Dale fellow
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
🚨New preprint alert 🚨
www.biorxiv.org/content/10.1...

Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
www.biorxiv.org
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Reposted by Dr Laura McCulloch
gjbrainresearch.bsky.social
GJBrainResearch @gjbrainresearch.bsky.social · 20d
Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix).

🔬 Focus: chemokines, glycocalyx & inflammatory disease

📍 Cutting-edge biochem, biophysics & in vivo biology

Apply now 👉 shorturl.at/jEQ6G
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
shorturl.at
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Reposted by Dr Laura McCulloch
madhvimenon.bsky.social
Madhvi Menon @madhvimenon.bsky.social · Jun 20
🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in Mucosal Immunology :Manchester
www.jobs.manchester.ac.uk
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Reposted by Dr Laura McCulloch
jem.org
Journal of Experimental Medicine @jem.org · Jun 13
Explore new research on #Neuroimmunology & #Neurodegeneration, incl. macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...

#ksneuroimmune25 #ksneurodegen25 @keystonesymposia.bsky.social‬
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Reposted by Dr Laura McCulloch
edinburghimmuno.bsky.social
Edinburgh Immunology Group @edinburghimmuno.bsky.social · Jun 2
Please join us for the summer EIG mini symposium on Tuesday 17th of June. The session starts at 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 with talks by Prof Simon Graham, Dr Kate Sutton and Prof Christoph Scheiermann. See you there!
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Reposted by Dr Laura McCulloch
cp-cell.bsky.social
Cell - a Cell Press journal @cp-cell.bsky.social · Apr 29
Now online! Macrophages direct location-dependent recall of B cell memory to vaccination
Macrophages direct location-dependent recall of B cell memory to vaccination
Subcapsular sinus macrophages in the draining lymph node help retain resident memory B cells in the subcapsular niche and promote their re-entry into secondary germinal centers. Boosting vaccines in the same arm leads to more rapid secretion of broadly neutralizing antibodies.
dlvr.it
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
This was an exciting collaboration in @edinuni-irr.bsky.social driven by Rachel Martin and Isobel Mouat supported by Robert Whelan and @lizihegarty.bsky.social and collaboration with CJ Anderson, David Dockrell, @bainlab.bsky.social and @gwotzerho.bsky.social funded by @wellcometrust.bsky.social
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
Together these data show dynamic changes to the intestine and intestinal microbiome throughout stroke recovery and gives some insight into which factors may be responsible for prolonged gastrointestinal disturbance after stroke
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
We also found altered luminal IgG concentrations and reduced antibody coating of intestinal bacteria only at 3 months post stroke.
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
Changes to the composition of the microbiome were detected througout recovery. Surprisingly these changes were distinct at acute and chronic recovery time points suggesting different driving factors may be associated with these changes.
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
At our earliest timepoint, 5 days post stroke, there is a reduced mucus barrier in the colon and a delayed intestinal transit time. However these normalise in chronic recovery
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
We found lower body weights and structural changes to the colon persisted out to 3 months after experimental stroke (MCAO) in mice
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 29
🚨New preprint alert 🚨
www.biorxiv.org/content/10.1...

Delighted to share our recent study looking at chronic changes to the intestine and intestinal microbiome after stroke
www.biorxiv.org
1 3 6
Reposted by Dr Laura McCulloch
edinburghimmuno.bsky.social
Edinburgh Immunology Group @edinburghimmuno.bsky.social · Apr 28
The spring EIG session is coming this Thursday on 1st of May. Please join us from 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 for fantastic talks by Dr. Elizabeth Mann, Dr. Tovah Shaw and Prof. Hamida Hammad. See you there!
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Reposted by Dr Laura McCulloch
douglaspdyer.bsky.social
Doug Dyer @douglaspdyer.bsky.social · Apr 28
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Apr 9
blog.sciencemuseum.org.uk/the-most-com...
The most complete map of a brain is unveiled today - Science Museum Blog
Roger Highfield, Science Director, reports on the latest milestone in what is billed as the most complicated neuroscience experiment ever.
blog.sciencemuseum.org.uk
Reposted by Dr Laura McCulloch
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · Mar 30
'The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.'
www.nature.com/articles/d41...
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
www.nature.com
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Reposted by Dr Laura McCulloch
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Mar 11
Heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload
www.cell.com/immunity/ful...
preview @cp-immunity.bsky.social
www.cell.com/immunity/ful...
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Reposted by Dr Laura McCulloch
gamonasterioo.bsky.social
Gustavo Monasterio Ocares @gamonasterioo.bsky.social · Mar 6
Organ-specific sympathetic innervation defines visceral functions

www.nature.com/articles/s41...
Organ-specific sympathetic innervation defines visceral functions - Nature
Multi-modal transcriptomic analyses of the sympathetic nervous system reveal organ-specific neural innervation and modular regulation of visceral functions.
www.nature.com
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Reposted by Dr Laura McCulloch
jem.org
Journal of Experimental Medicine @jem.org · Mar 4
Stoler-Barak, @zivshulman.bsky.social et al. show that SMARCA5-mediated #chromatin remodeling is required for germinal center formation rupress.org/jem/article/...

📘 In Multifaceted B Cell Functions & Dysfunctions: rupress.org/jem/collecti...
#KSBCells25
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Reposted by Dr Laura McCulloch
jem.org
Journal of Experimental Medicine @jem.org · Feb 26
Our new collection highlights recent advances in B lymphocyte biology from homeostasis to inflammation & dysfunction leading to lymphoma development. Read new research accompanying @keystonesymposia.bsky.social on Multifaceted B Cell Functions & Dysfunctions: https://buff.ly/3CX1Y0O
#KSBCells25
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Reposted by Dr Laura McCulloch
franzeprogatzky.bsky.social
Fränze Progatzky @franzeprogatzky.bsky.social · Feb 24
🚨 We have TWO exciting open positions in our lab! 🚨

We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:

🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...

💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...

📢 Please share!
Research Assistant (177885)
We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Fränze Progatzky at the Kennedy Institute.
www.kennedy.ox.ac.uk
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Reposted by Dr Laura McCulloch
graemecowan.bsky.social
Graeme Cowan 🧬👨🏻‍💻 @graemecowan.bsky.social · Feb 17
Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30.

Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.

www.frontiersin.org/journals/imm...
Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome
www.frontiersin.org
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dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Feb 22
Sorry to hear that, but I'm happy you've had a good recovery
dr-l-mcculloch.bsky.social
Dr Laura McCulloch @dr-l-mcculloch.bsky.social · Feb 20
First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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