Extreme weather events, from heavy rainfall to heat waves and droughts, are increasingly threatening crop yields globally, so new solutions are needed for agriculture.

Bacteria often experience nutrient limitation and, in response, attenuate energetically costly metabolic processes like protein synthesis. At the same time, however, they stimulate the expression of a subset of proteins that facilitate survival under ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

This study reveals that acute aerobic exercise enhances memory formation through a controlled DNA damage mechanism, offering crucial insights into Alzheimer's disease (AD) prevention. This work challe...

During one round of DNA replication, nearly 2,000 ribonucleoside monophosphates (rNMPs) are incorporated in place of their cognate deoxyribonucleoside monophosphate (dNMP). Given their high rate of in...

The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the pho...

Nature Biotechnology - Mining archaea for antibiotics

When talking about Staphylococcus aureus, one usually has in mind the diseases that can be caused by this bacterium, ranging from mild skin and soft tissue infections, such as abscesses and furuncles,...

Hyperspectral reporter genes allow imaging of ground bacteria from aerial vehicles

Advancements in the life sciences have always been built upon our collective understanding of life on Earth. Now, the rise of generative biology - the use of AI foundation models to design, generate, ...

Broad scientists describe how data resources they helped build over more than a decade now form the foundation for cutting-edge AI and genome biology discoveries.

Plants may be stuck in one place, but the world around them is constantly changing. In order to grow and flower at the right time, plants must constantly collect information about their surroundings, measuring things like temperature, brightness, and length of day.

Guo et al. perform a systematic assessment of genetic dependencies and cell surface targets in pancreatic adenocarcinoma, identifying biomarkers, mapping interpatient and intratumoral heterogeneity, and nominating combination strategies. Experimental validation of dependencies associated with mesenchymal/EMT gene expression signatures identified the CDS2 enzyme as a mesenchymal state selective dependency.

Thermococcus species are ubiquitously distributed across both shallow and deep-sea hydrothermal vent ecosystems. Elemental sulfur (S°) reduction plays a pivo...

Experiments show that E. coli bacteria employ a number of strategies to explore complex environments, navigating mazes and fractals much more efficiently than would be expected for a random walk.

Use of artificial intelligence to mine proteomes of archaea led to the discovery of archaeasins, antimicrobials that kill drug-resistant bacteria in laboratory and animal models, offering a promising ...

Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...

A generative AI platform is developed for de novo antibiotic design, yielding lead compounds with selective antibacterial activity, distinct mechanisms of action, and in vivo efficacy against multidru...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports.

A study published in Nature Biotechnology reveals a powerful new use for artificial intelligence: designing small, drug-like molecules that can stick to and break down harmful proteins in the body—even when scientists don't know what those proteins look like.