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Shu-Sin Chng

@figlegend.bsky.social

390 followers 300 following 66 posts

Assoc Professor @ National University of Singapore. 🇸🇬 NUS Assoc Dir for SCELSE. Membrane/lipid biochemist. Educator who teaches chemistry in biology. Advocate (Vice Dean) for students. Horn player. 📯📯 https://chemistry.nus.edu.sg/people/chng-shu-sin/

chemistry.nus.edu.sg

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Shu-Sin Chng @figlegend.bsky.social · Jul 2

Great news - this work is now published!! Big congrats to @yeowjiang.bsky.social - amazing that he mastered cryo-EM and now solved his 2nd set of strs! And kudos to Chee Geng (& Nadege) for non-trivial homogeneous purification of TolQRA!

pubs.acs.org/doi/10.1021/...

#MicroSky #SGBUG 1/4

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Syma Khalid @sykhalid.bsky.social · 7d

Come join us in Oxford! Two positions open right now in @oxfordbiochemistry.bsky.social
It’s a great place to work. Really supportive colleagues, great students, colleges provide a unique social environment - in summary, it’s a lot of fun.

Tobias Warnecke @tobiaswarnecke.bsky.social · 9d

Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism

my.corehr.com/pls/uoxrecru...

Job Details

my.corehr.com

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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 8d

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson

www.gla.ac.uk

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Andy Edwards @bugsinblood.bsky.social · 9d

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

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Géraldine Laloux @lalouxlab.bsky.social · 13d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Jan-Willem Veening @veeninglab.com · 12d

Nice work on tackling genetic interactions in the pneumococcus! If you like this, you will also like our work doing the same thing using dual CRISPRi. Coming soon in @cp-cellsystems.bsky.social www.biorxiv.org/content/10.1...

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Sarah Svensson @campy-bara.bsky.social · 13d

Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science www.science.org/doi/10.1126/...

Dual transposon sequencing profiles the genetic interaction landscape in bacteria

Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...

www.science.org

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.

www.marles-wright-lab.org

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 15d

The @henrikstrahl.bsky.social group focuses on bacterial cell envelopes and envelope-targeting antibiotics.
Using cell biology, high-end fluorescence microscopy, genetics, and biochemistry, they study the function, biosynthesis and organisation of bacterial cell membranes.

strahllab.weebly.com

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 15d

Dr Alistair Brown’s group is interested in mycobacterial biology, focusing on antimicrobial drug discovery and elucidation of drug mechanisms of action. They aim to understand how existing and novel compounds affect mycobacterial growth, survival, and persistence.

@mycobacterium-ncl.bsky.social

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 15d

Dr Chien-Yi Chang's lab studies how Gram-negative bacteria sense and respond to different environments using molecular and bioimaging approaches.

👉 @davychang.bsky.social

chienyichang.wixsite.com/changlab

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 15d

The Salgado group focuses on structural and functional characterisation of proteins involved in pathogenicity pathways in C. difficile. They are particularly interested in S-layer and sporulation proteins and their role in infection.

Follow @pssalgado.bsky.social

salgadolab.org

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 15d

Next up,

Dr Kate Beckham @kshbeckham.bsky.social

The Beckham lab is interested mycobacterial membrane transport processes. They focusing on understanding the steps occurring at the mycobacterial outer membrane.

www.ncl.ac.uk/cbcb/staff/p...

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Microbes in Health and Disease @mhd-newcastle.bsky.social · 15d

Day 2 of MHD introductions 😃

Dr Lis Lowe @lislowe.bsky.social

The Lowe lab is focussed on microbial glycobiology. They work on bacterial Cazymes from commensals and pathogens, and are particularly interested in enzymes that target microbial glycans such as the cell walls of Mycobacteria.

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SCELSE - a biofilm & microbiome research centre in NTU & NUS @scelse.bsky.social · 14d

Check out this talk on 30 Sep 2025 - Tackling the global spread of AMR using genome-resolved metagenomics and Al - by Dr Niranjan Nagarajan, and hosted by @fillouxlab.bsky.social

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Freya Harrison @friendlymicrobe.bsky.social · 14d

A colleague received proofs of an accepted manuscript, and the "proofing process" clearly involved running the text through ChatGPT. Their voice has been erased, and errors introduced. This is from a supposedly reputable publisher. Anyone else been put through this particular form of hell? #MicroSky

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Wilbert Bitter @wilbertbitter.bsky.social · 15d

PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this

PPE51 modulates membrane integrity in Mycobacterium marinum | mBio

The impermeable outer membrane of pathogenic mycobacteria presents a major obstacle to nutrient acquisition and antibiotic penetration. PPE51, a substrate of the ESX-5 secretion system, has previously...

journals.asm.org

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Rhys Grinter @rhyswg.bsky.social · 18d

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

www.biorxiv.org

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Enninga Lab @enningalab.bsky.social · 20d

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 21d

Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1

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Shu-Sin Chng @figlegend.bsky.social · 22d

If you are attending the Great Wall Symposium happening this week in Sicily, do check out Wei-Chuen Poh's @skylarpoh95.bsky.social poster on very interesting TolB variants he has found, which might help us think deeper about the function of the Tol-Pal complex! Poster 93!! #MicroSky

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Shu-Sin Chng @figlegend.bsky.social · 23d

Build on our recent work (Nature (2018) 564:77, Nat Microbiol (2021) 6:221, Nat Microbiol (2024) 9:1089, bioRxiv (2025) www.biorxiv.org/content/10.1...) by carrying out prot biochem, cell biol, & fluorescence imaging expts. Assoc str analysis of proteins by cryo-EM will be undertaken via collab. 2/2

Shu-Sin Chng @figlegend.bsky.social · 23d

Helping Ben Berks
with an ad.

Postdoc Research Associate in the Molecular Analysis of Bacterial Protein Transport

Join the group of Prof Ben Berks to study the bacterial Type 9 Secretion System.

my.corehr.com/pls/uoxrecru...

1/2

my.corehr.com

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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 26d

Class A PBPs reinforce the septal cell wall following initial synthesis by SEDS-bPBP pairs during bacterial cytokinesis https://www.biorxiv.org/content/10.1101/2025.09.12.675754v1

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José R Penadés @jrpenades.bsky.social · 29d

Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization

Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

www.cell.com

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Gc Rox @gcrox.bsky.social · Sep 6

Postdoc position (please re-post)
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
[email protected]
#MicroSky

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